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Wsb2 WD repeat and SOCS box-containing 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 288692, updated on 4-Jan-2025

Summary

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Official Symbol
Wsb2provided by RGD
Official Full Name
WD repeat and SOCS box-containing 2provided by RGD
Primary source
RGD:1359599
See related
EnsemblRapid:ENSRNOG00000001135 AllianceGenome:RGD:1359599
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in protein polyubiquitination. Orthologous to human WSB2 (WD repeat and SOCS box containing 2). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Heart (RPKM 327.2), Brain (RPKM 289.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Wsb2 in Genome Data Viewer
Location:
12q16
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (44878483..44899474, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (39217645..39238634, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (44941655..44962679, complement)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481300 Neighboring gene replication factor C subunit 5 Neighboring gene V-set and immunoglobulin domain containing 10 Neighboring gene phosphatidylethanolamine binding protein 1 Neighboring gene uncharacterized LOC120095992

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The SOCS box: a tale of destruction and degradation. Kile BT, et al. Trends Biochem Sci, 2002 May. PMID 12076535
  2. A germline-specific class of small RNAs binds mammalian Piwi proteins. Girard A, et al. Nature, 2006 Jul 13. PMID 16751776
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC93822

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
WD repeat and SOCS box-containing protein 2
Names
WD SOCS-box protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007616.3 → NP_001007617.1  WD repeat and SOCS box-containing protein 2 isoform 1

    See identical proteins and their annotated locations for NP_001007617.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/TrEMBL
    A6J1N8, Q66HE3
    Related
    ENSRNOP00000097041.2, ENSRNOT00000108322.2
    Conserved Domains (3) summary
    cd00200
    Location:121 → 360
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cd03733
    Location:364 → 402
    SOCS_WSB_SWIP; SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2), and SWiP-1 ...
    sd00039
    Location:157 → 195
    7WD40; WD40 repeat [structural motif]

  2. NM_001415754.1 → NP_001402683.1  WD repeat and SOCS box-containing protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    44878483..44899474 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063271211.1 → XP_063127281.1  WD repeat and SOCS box-containing protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I5Y8A6, A6J1N8, F7F7B9
Nucleotide Protein Strain
Heading Accession and Version

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