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Tpst2 tyrosylprotein sulfotransferase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 288719, updated on 4-Jan-2025

Summary

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Official Symbol
Tpst2provided by RGD
Official Full Name
tyrosylprotein sulfotransferase 2provided by RGD
Primary source
RGD:1305331
See related
EnsemblRapid:ENSRNOG00000000664 AllianceGenome:RGD:1305331
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
TPST-2
Summary
Predicted to enable protein homodimerization activity and protein-tyrosine sulfotransferase activity. Predicted to be involved in peptidyl-tyrosine sulfation. Predicted to act upstream of or within fusion of sperm to egg plasma membrane involved in single fertilization and prevention of polyspermy. Predicted to be located in endoplasmic reticulum. Predicted to be active in Golgi lumen and trans-Golgi network. Orthologous to human TPST2 (tyrosylprotein sulfotransferase 2). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Adrenal (RPKM 124.0), Heart (RPKM 111.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tpst2 in Genome Data Viewer
Location:
12q16
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (49982281..50024489, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (44321875..44363892, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (50343076..50383534, complement)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene coiled-coil domain-containing protein 121-like Neighboring gene HPS4, biogenesis of lysosomal organelles complex 3 subunit 2 Neighboring gene SRR1 domain containing Neighboring gene tuftelin interacting protein 11 Neighboring gene crystallin, beta B1 Neighboring gene crystallin, beta A4 Neighboring gene uncharacterized LOC134481212 Neighboring gene myocardial infarction associated transcript

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Crystal structure of human tyrosylprotein sulfotransferase-2 reveals the mechanism of protein tyrosine sulfation reaction. Teramoto T, et al. Nat Commun, 2013. PMID 23481380, Free PMC Article
  2. Detection and purification of tyrosine-sulfated proteins using a novel anti-sulfotyrosine monoclonal antibody. Hoffhines AJ, et al. J Biol Chem, 2006 Dec 8. PMID 17046811, Free PMC Article
  3. Lack of tyrosylprotein sulfotransferase-2 activity results in altered sperm-egg interactions and loss of ADAM3 and ADAM6 in epididymal sperm. Marcello MR, et al. J Biol Chem, 2011 Apr 15. PMID 21339297, Free PMC Article
  4. Molecular cloning and expression of human and mouse tyrosylprotein sulfotransferase-2 and a tyrosylprotein sulfotransferase homologue in Caenorhabditis elegans. Ouyang YB, et al. J Biol Chem, 1998 Sep 18. PMID 9733778
  5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC105657

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-tyrosine sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-tyrosine sulfotransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-tyrosine sulfotransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-tyrosine sulfotransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within fusion of sperm to egg plasma membrane involved in single fertilization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within peptidyl-tyrosine sulfation ISO
Inferred from Sequence Orthology
more info
  
involved_in peptidyl-tyrosine sulfation ISO
Inferred from Sequence Orthology
more info
  
involved_in peptidyl-tyrosine sulfation ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within prevention of polyspermy ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in Golgi lumen ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
is_active_in trans-Golgi network ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein-tyrosine sulfotransferase 2
NP_001008508.2
XP_038945198.1
XP_038945200.1
XP_063127287.1
XP_063127288.1
XP_063127289.1
XP_063127290.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008508.3 → NP_001008508.2  protein-tyrosine sulfotransferase 2

    See identical proteins and their annotated locations for NP_001008508.2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/Swiss-Prot
    Q5RJS8
    UniProtKB/TrEMBL
    A0A8L2PYI1, A6J265
    Conserved Domains (1) summary
    pfam13469
    Location:84 → 275
    Sulfotransfer_3; Sulfotransferase family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    49982281..50024489 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039089270.2 → XP_038945198.1  protein-tyrosine sulfotransferase 2 isoform X4

    UniProtKB/Swiss-Prot
    Q5RJS8
    Related
    ENSRNOP00000000831.6, ENSRNOT00000000831.6
    Conserved Domains (1) summary
    pfam13469
    Location:120 → 311
    Sulfotransfer_3; Sulfotransferase family

  2. XM_063271219.1 → XP_063127289.1  protein-tyrosine sulfotransferase 2 isoform X3

    UniProtKB/Swiss-Prot
    Q5RJS8
    UniProtKB/TrEMBL
    A0A8L2PYI1, A6J265

  3. XM_039089272.2 → XP_038945200.1  protein-tyrosine sulfotransferase 2 isoform X3

    UniProtKB/Swiss-Prot
    Q5RJS8
    UniProtKB/TrEMBL
    A0A8L2PYI1, A6J265
    Conserved Domains (1) summary
    pfam13469
    Location:84 → 275
    Sulfotransfer_3; Sulfotransferase family

  4. XM_063271218.1 → XP_063127288.1  protein-tyrosine sulfotransferase 2 isoform X2

    UniProtKB/TrEMBL
    A0A8I6AQ08

  5. XM_063271217.1 → XP_063127287.1  protein-tyrosine sulfotransferase 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AQ08

  6. XM_063271220.1 → XP_063127290.1  protein-tyrosine sulfotransferase 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AQ08

RNA

  1. XR_010056380.1 RNA Sequence

    Related
    ENSRNOT00000159288.1

  2. XR_005491621.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5RJS8.1 GenPept UniProtKB/Swiss-Prot:Q5RJS8

Gene LinkOut

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