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Chfr checkpoint with forkhead and ring finger domains [ Rattus norvegicus (Norway rat) ]

Gene ID: 288734, updated on 4-Jan-2025

Summary

Official Symbol
Chfrprovided by RGD
Official Full Name
checkpoint with forkhead and ring finger domainsprovided by RGD
Primary source
RGD:1306360
See related
EnsemblRapid:ENSRNOG00000037430 AllianceGenome:RGD:1306360
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable nucleotide binding activity and ubiquitin protein ligase activity. Predicted to be involved in meiotic spindle checkpoint signaling; mitotic G2/M transition checkpoint; and ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within several processes, including positive regulation of protein metabolic process; protein destabilization; and protein polyubiquitination. Predicted to be located in PML body. Predicted to be active in nucleus. Orthologous to human CHFR (checkpoint with forkhead and ring finger domains). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Thymus (RPKM 121.0), Spleen (RPKM 90.3) and 9 other tissues See more
Orthologs
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Genomic context

See Chfr in Genome Data Viewer
Location:
12q16
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (52164214..52197860, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (46504497..46538104, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (52562594..52596162, complement)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene ankyrin repeat and LEM domain containing 2 Neighboring gene golgin A3 Neighboring gene uncharacterized LOC134481217 Neighboring gene zinc finger protein 605 Neighboring gene RIKEN cDNA B230307C23 gene like Neighboring gene GTP binding protein 6 (putative) Neighboring gene phosphatidylinositol-specific phospholipase C, X domain containing 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC95316

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in PML body ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase CHFR
Names
checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase
NP_001009258.1
XP_006249597.1
XP_006249598.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009258.1NP_001009258.1  E3 ubiquitin-protein ligase CHFR

    See identical proteins and their annotated locations for NP_001009258.1

    Status: PROVISIONAL

    Source sequence(s)
    BC087162
    UniProtKB/TrEMBL
    A6J2C9, F1LN16, Q5PQJ8
    Conserved Domains (3) summary
    COG1716
    Location:27140
    FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
    cd00060
    Location:16105
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd00162
    Location:302345
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    52164214..52197860 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006249535.5XP_006249597.1  E3 ubiquitin-protein ligase CHFR isoform X1

    UniProtKB/TrEMBL
    A0A8J8XDG1, A6J2C9
    Related
    ENSRNOP00000053478.4, ENSRNOT00000056639.5
    Conserved Domains (3) summary
    COG1716
    Location:27140
    FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
    cd00060
    Location:16105
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd00162
    Location:302345
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
  2. XM_006249536.5XP_006249598.1  E3 ubiquitin-protein ligase CHFR isoform X2

    UniProtKB/TrEMBL
    A0A8I5XWV2, A6J2C9
    Related
    ENSRNOP00000078152.1, ENSRNOT00000099226.2
    Conserved Domains (3) summary
    COG1716
    Location:27140
    FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
    cd00060
    Location:16105
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd00162
    Location:302345
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...