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Slc19a2 solute carrier family 19 member 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 289175, updated on 4-Jan-2025

Summary

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Official Symbol
Slc19a2provided by RGD
Official Full Name
solute carrier family 19 member 2provided by RGD
Primary source
RGD:1308611
See related
EnsemblRapid:ENSRNOG00000002839 AllianceGenome:RGD:1308611
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable thiamine transmembrane transporter activity. Predicted to be involved in several processes, including pyridoxine transport; thiamine diphosphate biosynthetic process; and thiamine transmembrane transport. Predicted to be active in plasma membrane. Biomarker of chronic kidney disease. Human ortholog(s) of this gene implicated in diabetes mellitus; megaloblastic anemia; and thiamine-responsive megaloblastic anemia syndrome. Orthologous to human SLC19A2 (solute carrier family 19 member 2). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Liver (RPKM 394.6), Kidney (RPKM 92.7) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Slc19a2 in Genome Data Viewer
Location:
13q23
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (79135118..79149316)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (76601975..76616175)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (82552586..82566586)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene selectin P Neighboring gene uncharacterized LOC134481524 Neighboring gene coagulation factor V Neighboring gene coiled-coil domain containing 181 Neighboring gene basic leucine zipper nuclear factor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Involvement of reduced folate carrier 1 in the inner blood-retinal barrier transport of methyltetrahydrofolate. Hosoya K, et al. Drug Metab Pharmacokinet, 2008. PMID 18762716
  2. Mutations in SLC19A2 cause thiamine-responsive megaloblastic anaemia associated with diabetes mellitus and deafness. Labay V, et al. Nat Genet, 1999 Jul. PMID 10391221
  3. Identification of a mouse thiamine transporter gene as a direct transcriptional target for p53. Lo PK, et al. J Biol Chem, 2001 Oct 5. PMID 11481326
  4. Tspan-1 interacts with the thiamine transporter-1 in human intestinal epithelial cells and modulates its stability. Nabokina SM, et al. Am J Physiol Gastrointest Liver Physiol, 2011 Nov. PMID 21836059, Free PMC Article
  5. Effect of chronic kidney disease on the expression of thiamin and folic acid transporters. Bukhari FJ, et al. Nephrol Dial Transplant, 2011 Jul. PMID 21149507, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. involvement of RFC1 in the inner BRB transport of methyltetrahydrofolate.
    Title: Involvement of reduced folate carrier 1 in the inner blood-retinal barrier transport of methyltetrahydrofolate.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC124887

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables thiamine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables thiamine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in pyridoxine transport ISO
Inferred from Sequence Orthology
more info
  
involved_in spermatogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in thiamine diphosphate biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in thiamine transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in thiamine transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within thiamine transport ISO
Inferred from Sequence Orthology
more info
  
involved_in thiamine transport ISO
Inferred from Sequence Orthology
more info
  
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
thiamine transporter 1
Names
solute carrier family 19 (thiamine transporter), member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001030024.2 → NP_001025195.1  thiamine transporter 1

    See identical proteins and their annotated locations for NP_001025195.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/TrEMBL
    A0A8I5ZVN5, Q499Q0
    Related
    ENSRNOP00000083604.1, ENSRNOT00000119412.2
    Conserved Domains (1) summary
    pfam01770
    Location:28 → 459
    Folate_carrier; Reduced folate carrier

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    79135118..79149316
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039090492.2 → XP_038946420.1  thiamine transporter 1 isoform X1

    UniProtKB/TrEMBL
    A0A096MJE7
    Related
    ENSRNOP00000068102.2, ENSRNOT00000076722.4
    Conserved Domains (1) summary
    pfam01770
    Location:37 → 436
    Folate_carrier; Reduced folate carrier

  2. XM_039090493.2 → XP_038946421.1  thiamine transporter 1 isoform X2

    UniProtKB/TrEMBL
    F1LNC9
    Related
    ENSRNOP00000003817.6, ENSRNOT00000003817.7
    Conserved Domains (1) summary
    pfam01770
    Location:22 → 416
    Folate_carrier; Reduced folate carrier

  3. XM_039090494.2 → XP_038946422.1  thiamine transporter 1 isoform X3

    Conserved Domains (1) summary
    pfam01770
    Location:16 → 415
    Folate_carrier; Reduced folate carrier

  4. XM_039090495.2 → XP_038946423.1  thiamine transporter 1 isoform X4

    Related
    ENSRNOP00000076963.2, ENSRNOT00000076186.3
    Conserved Domains (1) summary
    pfam01770
    Location:5 → 395
    Folate_carrier; Reduced folate carrier

  5. XM_039090496.1 → XP_038946424.1  thiamine transporter 1 isoform X5

    Conserved Domains (1) summary
    pfam01770
    Location:1 → 346
    Folate_carrier; Reduced folate carrier
Nucleotide Protein Strain
Heading Accession and Version

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