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Tatdn3 TatD DNase domain containing 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 289378, updated on 4-Jan-2025

Summary

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Official Symbol
Tatdn3provided by RGD
Official Full Name
TatD DNase domain containing 3provided by RGD
Primary source
RGD:1589779
See related
EnsemblRapid:ENSRNOG00000046460 AllianceGenome:RGD:1589779
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable hydrolase activity, acting on ester bonds and metal ion binding activity. Predicted to be located in mitochondrion. Orthologous to human TATDN3 (TatD DNase domain containing 3). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Heart (RPKM 67.3), Muscle (RPKM 44.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tatdn3 in Genome Data Viewer
Location:
13q27
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (105165384..105180167, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (102634254..102649069, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (109655292..109669573, complement)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene FLVCR choline and heme transporter 1 Neighboring gene spermatogenesis associated 45 Neighboring gene NSL1 component of MIS12 kinetochore complex Neighboring gene uncharacterized LOC120096350 Neighboring gene basic leucine zipper ATF-like transcription factor 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
  2. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables hydrolase activity, acting on ester bonds IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
putative deoxyribonuclease TATDN3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105987.1 → NP_001099457.1  putative deoxyribonuclease TATDN3

    See identical proteins and their annotated locations for NP_001099457.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473985
    UniProtKB/TrEMBL
    A6JGY3, M0R5U3
    Related
    ENSRNOP00000064772.4, ENSRNOT00000073327.4
    Conserved Domains (1) summary
    cd01310
    Location:5 → 262
    TatD_DNAse; TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    105165384..105180167 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039090602.2 → XP_038946530.2  putative deoxyribonuclease TATDN3 isoform X5

    UniProtKB/TrEMBL
    M0R5U3

  2. XM_039090601.2 → XP_038946529.2  putative deoxyribonuclease TATDN3 isoform X4

    UniProtKB/TrEMBL
    M0R5U3

  3. XM_039090600.2 → XP_038946528.2  putative deoxyribonuclease TATDN3 isoform X3

    UniProtKB/TrEMBL
    M0R5U3

  4. XM_039090599.2 → XP_038946527.2  putative deoxyribonuclease TATDN3 isoform X2

    UniProtKB/TrEMBL
    M0R5U3

  5. XM_039090598.2 → XP_038946526.2  putative deoxyribonuclease TATDN3 isoform X1

    UniProtKB/TrEMBL
    M0R5U3
    Related
    ENSRNOP00000107959.1, ENSRNOT00000173931.1

  6. XM_063272188.1 → XP_063128258.1  putative deoxyribonuclease TATDN3 isoform X6

  7. XM_063272190.1 → XP_063128260.1  putative deoxyribonuclease TATDN3 isoform X8

  8. XM_039090604.2 → XP_038946532.1  putative deoxyribonuclease TATDN3 isoform X6

    Conserved Domains (1) summary
    pfam01026
    Location:19 → 199
    TatD_DNase; TatD related DNase

  9. XM_063272189.1 → XP_063128259.1  putative deoxyribonuclease TATDN3 isoform X8

  10. XM_039090605.2 → XP_038946533.1  putative deoxyribonuclease TATDN3 isoform X7

    Conserved Domains (1) summary
    cl00281
    Location:50 → 114
    metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...

RNA

  1. XR_005492231.2 RNA Sequence

  2. XR_010056912.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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