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Ddx59 DEAD-box helicase 59 [ Rattus norvegicus (Norway rat) ]

Gene ID: 289402, updated on 27-Nov-2024

Summary

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Official Symbol
Ddx59provided by RGD
Official Full Name
DEAD-box helicase 59provided by RGD
Primary source
RGD:1359520
See related
EnsemblRapid:ENSRNOG00000042451 AllianceGenome:RGD:1359520
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable RNA helicase activity and mRNA binding activity. Predicted to be located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in orofaciodigital syndrome V. Orthologous to human DDX59 (DEAD-box helicase 59). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 53.3), Lung (RPKM 44.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ddx59 in Genome Data Viewer
Location:
13q13
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (50427940..50452893)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (47876258..47901214)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (53299872..53324824)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene calmodulin regulated spectrin-associated protein family, member 2 Neighboring gene uncharacterized LOC134481565 Neighboring gene ribosomal protein L31 like 9 Neighboring gene uncharacterized LOC102547307 Neighboring gene kinesin family member 14 Neighboring gene small nuclear ribonucleoprotein polypeptide B2, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC93714

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent H2AZ histone chaperone activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent H3-H4 histone complex chaperone activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA clamp loader activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables chromatin extrusion motor activity IEA
Inferred from Electronic Annotation
more info
  
enables cohesin loader activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chromatin looping IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
probable ATP-dependent RNA helicase DDX59
Names
DEAD (Asp-Glu-Ala-Asp) box polypeptide 59
DEAD box protein 59
zinc finger HIT domain-containing protein 5
NP_001005535.1
NP_001177749.1
XP_038946541.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005535.2 → NP_001005535.1  probable ATP-dependent RNA helicase DDX59 isoform 2

    See identical proteins and their annotated locations for NP_001005535.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    BC081871, CR477587, DY310785, DY317721
    UniProtKB/Swiss-Prot
    Q66HG7
    UniProtKB/TrEMBL
    A0A8I6B2D5
    Related
    ENSRNOP00000049858.2, ENSRNOT00000043798.5
    Conserved Domains (1) summary
    PLN00206
    Location:89 → 563
    PLN00206; DEAD-box ATP-dependent RNA helicase; Provisional

  2. NM_001190820.1 → NP_001177749.1  probable ATP-dependent RNA helicase DDX59 isoform 1

    See identical proteins and their annotated locations for NP_001177749.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC081871, CO398251, CR477587, DY310785, DY317721
    UniProtKB/TrEMBL
    A0A8I6B2D5, A6ICI8, D4A2T7
    Related
    ENSRNOP00000047251.3, ENSRNOT00000042846.8
    Conserved Domains (1) summary
    PLN00206
    Location:89 → 593
    PLN00206; DEAD-box ATP-dependent RNA helicase; Provisional

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    50427940..50452893
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039090613.2 → XP_038946541.1  probable ATP-dependent RNA helicase DDX59 isoform X1

    UniProtKB/TrEMBL
    A0A8I6B2D5, A6ICI8, D4A2T7
    Conserved Domains (1) summary
    PLN00206
    Location:89 → 593
    PLN00206; DEAD-box ATP-dependent RNA helicase; Provisional
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q66HG7.1 GenPept UniProtKB/Swiss-Prot:Q66HG7

Gene LinkOut

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