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Atp6v1g3 ATPase H+ transporting V1 subunit G3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 289407, updated on 27-Nov-2024

Summary

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Official Symbol
Atp6v1g3provided by RGD
Official Full Name
ATPase H+ transporting V1 subunit G3provided by RGD
Primary source
RGD:1304635
See related
EnsemblRapid:ENSRNOG00000022480 AllianceGenome:RGD:1304635
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ATP hydrolysis activity; ATPase binding activity; and proton-transporting ATPase activity, rotational mechanism. Predicted to be involved in synaptic vesicle lumen acidification. Predicted to act upstream of or within proton transmembrane transport. Located in cytosol and plasma membrane. Orthologous to human ATP6V1G3 (ATPase H+ transporting V1 subunit G3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward (RPKM 169.0) See more
Orthologs
human mouse all
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Genomic context

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See Atp6v1g3 in Genome Data Viewer
Location:
13q13
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (52351787..52376784)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (49800256..49825247)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (55265794..55288651)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene terminal nucleotidyltransferase 2, pseudogene 1 Neighboring gene uncharacterized LOC102548579 Neighboring gene chaperonin containing Tcp1, subunit 3 (gamma), pseudogene 2 Neighboring gene NIMA-related kinase 7 Neighboring gene uncharacterized LOC120096259

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. V1 and V0 domains of the human H+-ATPase are linked by an interaction between the G and a subunits. Norgett EE, et al. J Biol Chem, 2007 May 11. PMID 17360703
  2. Diversity of mouse proton-translocating ATPase: presence of multiple isoforms of the C, d and G subunits. Sun-Wada GH, et al. Gene, 2003 Jan 2. PMID 12527205
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATPase binding ISO
Inferred from Sequence Orthology
more info
  
enables proton-transporting ATPase activity, rotational mechanism IBA
Inferred from Biological aspect of Ancestor
more info
  
enables proton-transporting ATPase activity, rotational mechanism ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in synaptic vesicle lumen acidification IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in synaptic vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of vacuolar proton-transporting V-type ATPase, V1 domain IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
V-type proton ATPase subunit G 3
Names
ATPase, H+ transporting, V1 subunit G
ATPase, H+ transporting, lysosomal V1 subunit G3
NP_001099461.1
XP_017454249.1
XP_017454250.1
XP_063128271.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105991.2 → NP_001099461.1  V-type proton ATPase subunit G 3

    See identical proteins and their annotated locations for NP_001099461.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/TrEMBL
    A6ICK6
    Conserved Domains (1) summary
    pfam03179
    Location:3 → 107
    V-ATPase_G; Vacuolar (H+)-ATPase G subunit

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    52351787..52376784
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017598760.3 → XP_017454249.1  V-type proton ATPase subunit G 3 isoform X1

    Conserved Domains (1) summary
    pfam03179
    Location:40 → 156
    V-ATPase_G; Vacuolar (H+)-ATPase G subunit

  2. XM_017598761.3 → XP_017454250.1  V-type proton ATPase subunit G 3 isoform X2

    UniProtKB/TrEMBL
    D3ZTZ4
    Related
    ENSRNOP00000032126.5, ENSRNOT00000029679.6

  3. XM_063272201.1 → XP_063128271.1  V-type proton ATPase subunit G 3 isoform X1

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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