Pla2g3 phospholipase A2, group III [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pla2g3provided by RGD
Official Full Name: phospholipase A2, group IIIprovided by RGD
Primary source: RGD:1305323
See related: EnsemblRapid:ENSRNOG00000025121 AllianceGenome:RGD:1305323
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable calcium-dependent phospholipase A2 activity. Acts upstream of or within negative regulation of gene expression. Predicted to be located in centriole and recycling endosome. Orthologous to human PLA2G3 (phospholipase A2 group III). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Brain (RPKM 9.4), Kidney (RPKM 3.0) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14q21

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (82589908..82597542)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (78367625..78373913)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (83724828..83730614)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Up-regulation of IL-1beta and sPLA2-III in the medial prefrontal cortex contributes to orofacial and somatic hyperalgesia induced by malocclusion via glial-neuron crosstalk.
Title: Up-regulation of IL-1β and sPLA2-III in the medial prefrontal cortex contributes to orofacial and somatic hyperalgesia induced by malocclusion via glial-neuron crosstalk.
The localization of mature/cleaved form of sPLA(2)-III in postsynaptic structures suggest a physiological role of the enzyme in neurotransmission or synaptic plasticity.
Title: Expression and localization of sPLA2-III in the rat CNS.
Group III secreted phospholipase A2 causes apoptosis in rat primary cortical neuronal cultures, but not in cortical astrocytes.
Title: Group III secreted phospholipase A2 causes apoptosis in rat primary cortical neuronal cultures.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium-dependent phospholipase A2 activity	ISO Inferred from Sequence Orthology more info
enables phospholipase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within acrosome assembly	ISO Inferred from Sequence Orthology more info
involved_in arachidonate secretion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell maturation	ISO Inferred from Sequence Orthology more info
involved_in cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in high-density lipoprotein particle remodeling	ISO Inferred from Sequence Orthology more info
involved_in lipid catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipoxygenase pathway	ISO Inferred from Sequence Orthology more info
involved_in low-density lipoprotein particle remodeling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within macrophage activation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mast cell degranulation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of amyloid-beta clearance	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidic acid metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phosphatidylcholine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylcholine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylethanolamine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylglycerol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylinositol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylserine metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phospholipid metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cytokine production involved in inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of histamine secretion by mast cell	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of macrophage derived foam cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mast cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of prostaglandin biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of prostaglandin secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within production of molecular mediator involved in inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in regulation of endocytic recycling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sperm axoneme assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in centriole	ISO Inferred from Sequence Orthology more info
located_in recycling endosome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: group 3 secretory phospholipase A2

NP_001099485.1

EC 3.1.1.4

XP_017454608.1

EC 3.1.1.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106015.1 → NP_001099485.1 group 3 secretory phospholipase A2 precursor

See identical proteins and their annotated locations for NP_001099485.1

Status: PROVISIONAL

Source sequence(s)

CH473963

UniProtKB/TrEMBL

A6IKB3, A6IKB4

Related

ENSRNOP00000031579.5, ENSRNOT00000029848.5

Conserved Domains (2) summary

cd04704
Location:151 → 247

PLA2_bee_venom_like; PLA2_bee_venom_like: A sub-family of Phospholipase A2, similar to bee venom PLA2. PLA2 is a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. Enzymatically active PLA2 cleaves the sn-2 position of the ...

cd04705
Location:299 → 424

PLA2_group_III_like; PLA2_group_III_like: A sub-family of Phospholipase A2, similar to human group III PLA2. PLA2 is a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. Enzymatically active PLA2 cleaves the sn-2 position ...