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Nacad NAC alpha domain containing [ Rattus norvegicus (Norway rat) ]

Gene ID: 289786, updated on 4-Jan-2025

Summary

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Official Symbol
Nacadprovided by RGD
Official Full Name
NAC alpha domain containingprovided by RGD
Primary source
RGD:1559824
See related
EnsemblRapid:ENSRNOG00000053875 AllianceGenome:RGD:1559824
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable unfolded protein binding activity. Predicted to be involved in protein targeting to membrane. Predicted to be part of nascent polypeptide-associated complex. Predicted to be active in cytoplasm. Orthologous to human NACAD (NAC alpha domain containing). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Brain (RPKM 99.5), Heart (RPKM 19.7) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Nacad in Genome Data Viewer
Location:
14q21
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (85679215..85688742, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (81465299..81473866, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (86860607..86868605, complement)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102547700 Neighboring gene small nucleolar RNA SNORA9 Neighboring gene CCM2 scaffold protein Neighboring gene uncharacterized protein C11orf98 homolog Neighboring gene small nucleolar RNA SNORA5 Neighboring gene transforming growth factor beta regulator 4 Neighboring gene small nucleolar RNA, H/ACA box 5C

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nascent polypeptide-associated complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
NAC-alpha domain-containing protein 1
NP_001094125.3
XP_038947687.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100655.3 → NP_001094125.3  NAC-alpha domain-containing protein 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014
    UniProtKB/TrEMBL
    F1M6E5
    Related
    ENSRNOP00000105565.1, ENSRNOT00000166406.1
    Conserved Domains (4) summary
    PHA03247
    Location:594 → 1105
    PHA03247; large tegument protein UL36; Provisional
    PRK07994
    Location:630 → 758
    PRK07994; DNA polymerase III subunits gamma and tau; Validated
    cd14416
    Location:1375 → 1416
    UBA_NACAD; UBA-like domain found in nascent polypeptide-associated complex subunit alpha domain-containing protein 1 (NACAD)
    cd22054
    Location:1280 → 1327
    NAC_NACA; nascent polypeptide-associated complex (NAC), alpha subunit

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    85679215..85688742 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039091759.2 → XP_038947687.1  NAC-alpha domain-containing protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZMB0
    Related
    ENSRNOP00000100754.1, ENSRNOT00000132648.1
    Conserved Domains (4) summary
    PHA03247
    Location:839 → 1385
    PHA03247; large tegument protein UL36; Provisional
    PRK14949
    Location:688 → 1044
    PRK14949; DNA polymerase III subunits gamma and tau; Provisional
    cd14416
    Location:1655 → 1696
    UBA_NACAD; UBA-like domain found in nascent polypeptide-associated complex subunit alpha domain-containing protein 1 (NACAD)
    cd22054
    Location:1560 → 1607
    NAC_NACA; nascent polypeptide-associated complex (NAC), alpha subunit
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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