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Fkbp8 FKBP prolyl isomerase 8 [ Rattus norvegicus (Norway rat) ]

Gene ID: 290652, updated on 9-Dec-2024

Summary

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Official Symbol
Fkbp8provided by RGD
Official Full Name
FKBP prolyl isomerase 8provided by RGD
Primary source
RGD:1308670
See related
EnsemblRapid:ENSRNOG00000058359 AllianceGenome:RGD:1308670
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
FKBP-8
Summary
Predicted to enable several functions, including calmodulin binding activity; disordered domain specific binding activity; and identical protein binding activity. Predicted to be involved in several processes, including negative regulation of protein phosphorylation; protein folding; and regulation of mitophagy. Predicted to act upstream of or within several processes, including nervous system development; positive regulation of BMP signaling pathway; and smoothened signaling pathway. Predicted to be located in endoplasmic reticulum membrane and mitochondrion. Predicted to be part of protein-containing complex. Predicted to be active in several cellular components, including cytosol; endomembrane system; and mitochondrial envelope. Orthologous to human FKBP8 (FKBP prolyl isomerase 8). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Liver (RPKM 633.4), Adrenal (RPKM 583.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Fkbp8 in Genome Data Viewer
Location:
16p14
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (18929581..18936621, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (18895608..18902648, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (20645956..20652890, complement)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene inositol-3-phosphate synthase 1 Neighboring gene elongation factor for RNA polymerase II Neighboring gene KxDL motif containing 1 Neighboring gene ubiquitin A-52 residue ribosomal protein fusion product 1 Neighboring gene required for excision 1-B domain containing

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. FKBP8 interact with classical swine fever virus NS5A protein and promote virus RNA replication. Li H, et al. Virus Genes, 2016 Feb. PMID 26748656
  2. Hepatitis C virus RNA replication is regulated by FKBP8 and Hsp90. Okamoto T, et al. EMBO J, 2006 Oct 18. PMID 17024179, Free PMC Article
  3. The flexible loop of Bcl-2 is required for molecular interaction with immunosuppressant FK-506 binding protein 38 (FKBP38). Kang CB, et al. FEBS Lett, 2005 Feb 28. PMID 15733859
  4. Mouse Fkbp8 activity is required to inhibit cell death and establish dorso-ventral patterning in the posterior neural tube. Wong RL, et al. Hum Mol Genet, 2008 Feb 15. PMID 18003640
  5. ZMYND10 functions in a chaperone relay during axonemal dynein assembly. Mali GR, et al. Elife, 2018 Jun 19. PMID 29916806, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC125185

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA polymerase II CTD heptapeptide repeat P3 isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II CTD heptapeptide repeat P6 isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables calmodulin binding ISO
Inferred from Sequence Orthology
more info
  
enables disordered domain specific binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables peptidyl-prolyl cis-trans isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein folding chaperone IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein folding chaperone ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within camera-type eye development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cell fate specification ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within dorsal/ventral neural tube patterning ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within dorsal/ventral pattern formation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within multicellular organism growth ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neural tube development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neuron fate specification ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein folding ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to mitochondrion ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mitophagy ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within smoothened signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrial envelope IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial envelope ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
peptidyl-prolyl cis-trans isomerase FKBP8
Names
FK506 binding protein 8, 38kDa
FK506-binding protein 8
PPIase FKBP8
rotamase
NP_001032257.1
XP_038950249.1
XP_038950250.1
XP_038950251.1
XP_038950254.1
XP_038950255.1
XP_038950256.1
XP_063131232.1
XP_063131233.1
XP_063131234.1
XP_063131235.1
XP_063131236.1
XP_063131237.1
XP_063131239.1
XP_063131240.1
XP_063131241.1
XP_063131242.1
XP_063131243.1
XP_063131244.1
XP_063131245.1
XP_063131246.1
XP_063131247.1
XP_063131248.1
XP_063131249.1
XP_063131250.1
XP_063131251.1
XP_063131252.1
XP_063131253.1
XP_063131254.1
XP_063131255.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037180.1 → NP_001032257.1  peptidyl-prolyl cis-trans isomerase FKBP8

    See identical proteins and their annotated locations for NP_001032257.1

    Status: PROVISIONAL

    Source sequence(s)
    BC107454
    UniProtKB/Swiss-Prot
    Q3B7U9
    UniProtKB/TrEMBL
    A0A8I6A3K9
    Related
    ENSRNOP00000087668.1, ENSRNOT00000095622.2
    Conserved Domains (3) summary
    COG0457
    Location:206 → 329
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:245 → 292
    TPR; TPR repeat [structural motif]
    pfam00254
    Location:103 → 192
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    18929581..18936621 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039094327.1 → XP_038950255.1  peptidyl-prolyl cis-trans isomerase FKBP8 isoform X8

    UniProtKB/TrEMBL
    A0A8I6A3K9
    Conserved Domains (3) summary
    COG0457
    Location:205 → 328
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:244 → 291
    TPR; TPR repeat [structural motif]
    pfam00254
    Location:103 → 191
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

  2. XM_063275173.1 → XP_063131243.1  peptidyl-prolyl cis-trans isomerase FKBP8 isoform X3

  3. XM_063275163.1 → XP_063131233.1  peptidyl-prolyl cis-trans isomerase FKBP8 isoform X1

  4. XM_039094321.2 → XP_038950249.1  peptidyl-prolyl cis-trans isomerase FKBP8 isoform X5

    UniProtKB/TrEMBL
    A0A8I6A3K9
    Related
    ENSRNOP00000074539.2, ENSRNOT00000077756.3
    Conserved Domains (3) summary
    COG0457
    Location:206 → 336
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:270 → 298
    TPR; TPR repeat [structural motif]
    pfam00254
    Location:103 → 192
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

  5. XM_063275174.1 → XP_063131244.1  peptidyl-prolyl cis-trans isomerase FKBP8 isoform X4

  6. XM_039094328.2 → XP_038950256.1  peptidyl-prolyl cis-trans isomerase FKBP8 isoform X8

    UniProtKB/TrEMBL
    A0A8I6A3K9
    Conserved Domains (3) summary
    COG0457
    Location:205 → 328
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:244 → 291
    TPR; TPR repeat [structural motif]
    pfam00254
    Location:103 → 191
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

  7. XM_063275180.1 → XP_063131250.1  peptidyl-prolyl cis-trans isomerase FKBP8 isoform X7

    UniProtKB/Swiss-Prot
    Q3B7U9
    UniProtKB/TrEMBL
    A0A8I6A3K9

  8. XM_063275181.1 → XP_063131251.1  peptidyl-prolyl cis-trans isomerase FKBP8 isoform X7

    UniProtKB/Swiss-Prot
    Q3B7U9
    UniProtKB/TrEMBL
    A0A8I6A3K9

  9. XM_063275172.1 → XP_063131242.1  peptidyl-prolyl cis-trans isomerase FKBP8 isoform X3

  10. XM_063275184.1 → XP_063131254.1  peptidyl-prolyl cis-trans isomerase FKBP8 isoform X8

    UniProtKB/TrEMBL
    A0A8I6A3K9

  11. XM_063275166.1 → XP_063131236.1  peptidyl-prolyl cis-trans isomerase FKBP8 isoform X2

  12. XM_063275162.1 → XP_063131232.1  peptidyl-prolyl cis-trans isomerase FKBP8 isoform X1

  13. XM_063275176.1 → XP_063131246.1  peptidyl-prolyl cis-trans isomerase FKBP8 isoform X4

  14. XM_063275169.1 → XP_063131239.1  peptidyl-prolyl cis-trans isomerase FKBP8 isoform X3

  15. XM_063275178.1 → XP_063131248.1  peptidyl-prolyl cis-trans isomerase FKBP8 isoform X6

    UniProtKB/TrEMBL
    A0A8I6A3K9

  16. XM_039094323.2 → XP_038950251.1  peptidyl-prolyl cis-trans isomerase FKBP8 isoform X5

    UniProtKB/TrEMBL
    A0A8I6A3K9
    Conserved Domains (3) summary
    COG0457
    Location:206 → 336
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:270 → 298
    TPR; TPR repeat [structural motif]
    pfam00254
    Location:103 → 192
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

  17. XM_063275177.1 → XP_063131247.1  peptidyl-prolyl cis-trans isomerase FKBP8 isoform X5

    UniProtKB/TrEMBL
    A0A8I6A3K9

  18. XM_039094326.1 → XP_038950254.1  peptidyl-prolyl cis-trans isomerase FKBP8 isoform X7

    UniProtKB/Swiss-Prot
    Q3B7U9
    UniProtKB/TrEMBL
    A0A8I6A3K9
    Conserved Domains (3) summary
    COG0457
    Location:206 → 329
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:245 → 292
    TPR; TPR repeat [structural motif]
    pfam00254
    Location:103 → 192
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

  19. XM_063275164.1 → XP_063131234.1  peptidyl-prolyl cis-trans isomerase FKBP8 isoform X1

  20. XM_063275183.1 → XP_063131253.1  peptidyl-prolyl cis-trans isomerase FKBP8 isoform X8

    UniProtKB/TrEMBL
    A0A8I6A3K9

  21. XM_063275175.1 → XP_063131245.1  peptidyl-prolyl cis-trans isomerase FKBP8 isoform X4

  22. XM_063275170.1 → XP_063131240.1  peptidyl-prolyl cis-trans isomerase FKBP8 isoform X3

  23. XM_039094322.2 → XP_038950250.1  peptidyl-prolyl cis-trans isomerase FKBP8 isoform X5

    UniProtKB/TrEMBL
    A0A8I6A3K9
    Conserved Domains (3) summary
    COG0457
    Location:206 → 336
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:270 → 298
    TPR; TPR repeat [structural motif]
    pfam00254
    Location:103 → 192
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

  24. XM_063275179.1 → XP_063131249.1  peptidyl-prolyl cis-trans isomerase FKBP8 isoform X6

    UniProtKB/TrEMBL
    A0A8I6A3K9

  25. XM_063275167.1 → XP_063131237.1  peptidyl-prolyl cis-trans isomerase FKBP8 isoform X2

  26. XM_063275182.1 → XP_063131252.1  peptidyl-prolyl cis-trans isomerase FKBP8 isoform X7

    UniProtKB/Swiss-Prot
    Q3B7U9
    UniProtKB/TrEMBL
    A0A8I6A3K9

  27. XM_063275185.1 → XP_063131255.1  peptidyl-prolyl cis-trans isomerase FKBP8 isoform X8

    UniProtKB/TrEMBL
    A0A8I6A3K9

  28. XM_063275165.1 → XP_063131235.1  peptidyl-prolyl cis-trans isomerase FKBP8 isoform X1

  29. XM_063275171.1 → XP_063131241.1  peptidyl-prolyl cis-trans isomerase FKBP8 isoform X3

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3B7U9.1 GenPept UniProtKB/Swiss-Prot:Q3B7U9

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