U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Adam24 ADAM metallopeptidase domain 24 [ Rattus norvegicus (Norway rat) ]

Gene ID: 290774, updated on 27-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Adam24provided by RGD
Official Full Name
ADAM metallopeptidase domain 24provided by RGD
Primary source
RGD:1309066
See related
EnsemblRapid:ENSRNOG00000038671 AllianceGenome:RGD:1309066
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable metalloendopeptidase activity. Predicted to be involved in male gonad development and proteolysis. Predicted to act upstream of or within prevention of polyspermy. Predicted to be active in external side of plasma membrane and sperm head plasma membrane. Orthologous to human ADAM20 (ADAM metallopeptidase domain 20). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward (RPKM 225.8) See more
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Adam24 in Genome Data Viewer
Location:
16q12.1
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (58281748..58287735, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (51578278..51584265, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (54625789..54631824, complement)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 7 member 2 Neighboring gene a disintegrin and metallopeptidase domain 25 Neighboring gene myotubularin related protein 7 Neighboring gene VPS37A subunit of ESCRT-I Neighboring gene CCR4-NOT transcription complex, subunit 7

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Testase 1 (ADAM 24) a sperm surface metalloprotease is required for normal fertility in mice. Zhu GZ, et al. Mol Reprod Dev, 2009 Nov. PMID 19670298
  2. Comprehensive analysis of reproductive ADAMs: relationship of ADAM4 and ADAM6 with an ADAM complex required for fertilization in mice. Han C, et al. Biol Reprod, 2009 May. PMID 19129510
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in male gonad development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within prevention of polyspermy ISO
Inferred from Sequence Orthology
more info
  
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in sperm head plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in sperm head plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
disintegrin and metalloproteinase domain-containing protein 24
Names
a disintegrin and metallopeptidase domain 24 (testase 1)
a disintegrin and metalloprotease domain 24 (testase 1)
a disintegrin and metalloproteinase domain 24

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001408681.1 → NP_001395610.1  disintegrin and metalloproteinase domain-containing protein 24 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016
    UniProtKB/TrEMBL
    F1LW54
    Related
    ENSRNOP00000040040.4, ENSRNOT00000042587.7

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    58281748..58287735 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools