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Coprs coordinator of PRMT5 and differentiation stimulator [ Rattus norvegicus (Norway rat) ]

Gene ID: 290925, updated on 4-Jan-2025

Summary

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Official Symbol
Coprsprovided by RGD
Official Full Name
coordinator of PRMT5 and differentiation stimulatorprovided by RGD
Primary source
RGD:1565675
See related
EnsemblRapid:ENSRNOG00000000111 AllianceGenome:RGD:1565675
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Copr5; RGD1565675
Summary
Predicted to enable histone binding activity. Predicted to be involved in chromatin remodeling and muscle organ development. Predicted to act upstream of or within blastocyst hatching. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Predicted to be active in nucleus. Orthologous to human COPRS (coordinator of PRMT5 and differentiation stimulator). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Kidney (RPKM 133.7), Brain (RPKM 92.4) and 9 other tissues See more
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Genomic context

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See Coprs in Genome Data Viewer
Location:
16q12.5
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (82423426..82428821)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (75721264..75726375)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (80826681..80831791)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene testis development related protein Neighboring gene F-box protein 25 Neighboring gene chromosome alignment maintaining phosphoprotein 1 Neighboring gene ubiquitin-like FUBI-ribosomal protein eS30 fusion protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The histone- and PRMT5-associated protein COPR5 is required for myogenic differentiation. Paul C, et al. Cell Death Differ, 2012 May. PMID 22193545, Free PMC Article
  2. The histone-binding protein COPR5 is required for nuclear functions of the protein arginine methyltransferase PRMT5. Lacroix M, et al. EMBO Rep, 2008 May. PMID 18404153, Free PMC Article
  3. Towards Functional Annotation of the Preimplantation Transcriptome: An RNAi Screen in Mammalian Embryos. Cui W, et al. Sci Rep, 2016 Nov 21. PMID 27869233, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within blastocyst hatching ISO
Inferred from Sequence Orthology
more info
  
involved_in chromatin remodeling ISO
Inferred from Sequence Orthology
more info
  
involved_in muscle organ development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
coordinator of PRMT5 and differentiation stimulator
Names
cooperator of PRMT5
coordinator of PRMT5, differentiation stimulator

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001169121.1 → NP_001162592.1  coordinator of PRMT5 and differentiation stimulator

    Status: VALIDATED

    Source sequence(s)
    CB614079
    UniProtKB/TrEMBL
    A6IWF3
    Conserved Domains (1) summary
    pfam15340
    Location:24 → 173
    COPR5; Cooperator of PRMT5 family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    82423426..82428821
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063275264.1 → XP_063131334.1  coordinator of PRMT5 and differentiation stimulator isoform X1

    UniProtKB/TrEMBL
    A6IWF3, A6IWF4, D3ZB92
    Related
    ENSRNOP00000000123.5, ENSRNOT00000000123.7
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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