Isca1 iron-sulfur cluster assembly 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Isca1provided by RGD
Official Full Name: iron-sulfur cluster assembly 1provided by RGD
Primary source: RGD:727792
See related: EnsemblRapid:ENSRNOG00000018343 AllianceGenome:RGD:727792
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Hbld2; hIscA
Summary: Predicted to enable 2 iron, 2 sulfur cluster binding activity. Predicted to be involved in iron-sulfur cluster assembly and protein maturation by iron-sulfur cluster transfer. Predicted to be part of mitochondrial [4Fe-4S] assembly complex. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in multiple mitochondrial dysfunctions syndrome 5. Orthologous to human ISCA1 (iron-sulfur cluster assembly 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Heart (RPKM 1087.6), Muscle (RPKM 1087.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 17p14

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (4910816..4923478)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (4905291..4917955)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (5281727..5294386)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A neuron-specific Isca1 knockout rat developments multiple mitochondrial dysfunction syndromes.
Title: A neuron-specific Isca1 knockout rat developments multiple mitochondrial dysfunction syndromes.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 2 iron, 2 sulfur cluster binding	IBA Inferred from Biological aspect of Ancestor more info
enables iron-sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in endocrine process	NAS Non-traceable Author Statement more info	PubMed
involved_in iron-sulfur cluster assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in iron-sulfur cluster assembly	IEA Inferred from Electronic Annotation more info
involved_in protein maturation by iron-sulfur cluster transfer	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
part_of mitochondrial [4Fe-4S] assembly complex	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: iron-sulfur cluster assembly 1 homolog, mitochondrial

Names: HESB like domain containing 2; HESB-like domain-containing protein 2; HesB protein; iron-sulfur assembly protein IscA

NP_853657.1

EC 2.7.7.52

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_181626.3 → NP_853657.1 iron-sulfur cluster assembly 1 homolog, mitochondrial precursor

See identical proteins and their annotated locations for NP_853657.1

Status: PROVISIONAL

Source sequence(s)

BC070929

UniProtKB/Swiss-Prot

Q80W96

UniProtKB/TrEMBL

A0A0A0MXZ0, A6KAG8

Related

ENSRNOP00000024781.6, ENSRNOT00000024781.8

Conserved Domains (1) summary

TIGR00049
Location:26 → 129

TIGR00049; Iron-sulfur cluster assembly accessory protein