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Rpp40 ribonuclease P/MRP subunit p40 [ Rattus norvegicus (Norway rat) ]

Gene ID: 291071, updated on 27-Nov-2024

Summary

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Official Symbol
Rpp40provided by RGD
Official Full Name
ribonuclease P/MRP subunit p40provided by RGD
Primary source
RGD:1310228
See related
EnsemblRapid:ENSRNOG00000016226 AllianceGenome:RGD:1310228
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ribonuclease P RNA binding activity. Predicted to contribute to ribonuclease MRP activity and ribonuclease P activity. Predicted to be involved in endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and tRNA 5'-leader removal. Predicted to be located in nucleolus. Predicted to be part of multimeric ribonuclease P complex and ribonuclease MRP complex. Orthologous to human RPP40 (ribonuclease P/MRP subunit p40). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 92.9), Thymus (RPKM 87.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rpp40 in Genome Data Viewer
Location:
17p12
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (29153203..29162241)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (28947752..28956788)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (29638647..29647709)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene LYR motif containing 4 Neighboring gene Histone deacetylase 1, pseudogene 16 Neighboring gene protein phosphatase 1, regulatory subunit 3G Neighboring gene chromodomain Y-like Neighboring gene uncharacterized LOC120097861 Neighboring gene ribosomal protein S7, pseudogene 16

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Unexpected diversity of RNase P, an ancient tRNA processing enzyme: challenges and prospects. Lai LB, et al. FEBS Lett, 2010 Jan 21. PMID 19931535, Free PMC Article
  2. Cryo-EM Structure of the Human Ribonuclease P Holoenzyme. Wu J, et al. Cell, 2018 Nov 15. PMID 30454648
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC108849

Gene Ontology Provided by RGD

Function Evidence Code Pubs
contributes_to ribonuclease MRP activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ribonuclease P RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables ribonuclease P RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables ribonuclease P RNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
contributes_to ribonuclease P activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ribonuclease P activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to ribonuclease P activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA 5'-leader removal IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA 5'-leader removal IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA 5'-leader removal ISO
Inferred from Sequence Orthology
more info
  
involved_in tRNA 5'-leader removal ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of multimeric ribonuclease P complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of multimeric ribonuclease P complex IEA
Inferred from Electronic Annotation
more info
  
part_of multimeric ribonuclease P complex ISO
Inferred from Sequence Orthology
more info
  
part_of multimeric ribonuclease P complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
part_of ribonuclease MRP complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ribonuclease P complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ribonuclease P protein subunit p40
Names
RNaseP protein p40
ribonuclease P 40 subunit
ribonuclease P/MRP 40 subunit
NP_001013073.1
NP_001386283.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013055.2 → NP_001013073.1  ribonuclease P protein subunit p40 isoform 1

    See identical proteins and their annotated locations for NP_001013073.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000017
    UniProtKB/TrEMBL
    A0A8L2QUY7
    Related
    ENSRNOP00000021877.4, ENSRNOT00000021877.7
    Conserved Domains (1) summary
    pfam08584
    Location:15 → 282
    Ribonuc_P_40; Ribonuclease P 40kDa (Rpp40) subunit

  2. NM_001399354.1 → NP_001386283.1  ribonuclease P protein subunit p40 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000017
    UniProtKB/Swiss-Prot
    Q5BK64
    Related
    ENSRNOP00000062962.2, ENSRNOT00000068617.5
    Conserved Domains (1) summary
    pfam08584
    Location:75 → 343
    Ribonuc_P_40; Ribonuclease P 40kDa (Rpp40) subunit

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    29153203..29162241
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5BK64.2 GenPept UniProtKB/Swiss-Prot:Q5BK64

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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