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Cndp2 carnosine dipeptidase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 291394, updated on 9-Dec-2024

Summary

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Official Symbol
Cndp2provided by RGD
Official Full Name
carnosine dipeptidase 2provided by RGD
Primary source
RGD:1305827
See related
EnsemblRapid:ENSRNOG00000015591 AllianceGenome:RGD:1305827
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable dipeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in nucleoplasm. Predicted to be active in cytosol. Orthologous to human CNDP2 (carnosine dipeptidase 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Kidney (RPKM 960.0), Lung (RPKM 294.1) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cndp2 in Genome Data Viewer
Location:
18q12.3
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (80314799..80331900, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (78039924..78057030, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (81521966..81539065, complement)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein 407 Neighboring gene carnosine dipeptidase 1 Neighboring gene divergent protein kinase domain 1C Neighboring gene preferentially expressed antigen in melanoma-like 7, pseudogene 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Assignment of the gene for dipeptidase 2 to Mus musculus chromosome 18 by somatic cell hybridization. Leinwand LA, et al. Biochem Genet, 1978 Jun. PMID 736882
  2. Electrophoretic heterogeneity of mouse erythrocyte peptidases. Lewis WH, et al. Biochem Genet, 1969 Oct. PMID 4187938
  3. Gene linkage analysis in the mouse by somatic cell hybridization: assignment of adenine phosphoribosyltransferase to chromosome 8 and alpha-galactosidase to the X chromosome. Kozak C, et al. Somatic Cell Genet, 1975 Oct. PMID 1235912
  4. Assignment of the genes for thymidine kinase and galactokinase to Mus musculus chromosome 11 and the preferential segregation of this chromosome in Chinese hamster/mouse somatic cell hybrids. Kozak CA, et al. Somatic Cell Genet, 1977 Mar. PMID 204065
  5. Gene mapping in Mus musculus by interspecific cell hybridization: assignment of the genes for tripeptidase-1 to chromosome 10, dipeptidase-2 to chromosome 18, acid phosphatase-1 to chromosome 12, and adenylate kinase-1 to chromosome 2. Francke U, et al. Cytogenet Cell Genet, 1977. PMID 198184

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables carboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables dipeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dipeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metallodipeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within proteolysis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cytosolic non-specific dipeptidase
Names
CNDP dipeptidase 2 (metallopeptidase M20 family)
cytosolic nonspecific dipeptidase 2
threonyl dipeptidase
NP_001010920.1
XP_006255061.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001010920.1 → NP_001010920.1  cytosolic non-specific dipeptidase

    See identical proteins and their annotated locations for NP_001010920.1

    Status: PROVISIONAL

    Source sequence(s)
    AY569013
    UniProtKB/Swiss-Prot
    Q6Q0N1
    UniProtKB/TrEMBL
    A6K5L5
    Related
    ENSRNOP00000021400.3, ENSRNOT00000021400.6
    Conserved Domains (2) summary
    PRK08201
    Location:3 → 473
    PRK08201; hypothetical protein; Provisional
    cd05676
    Location:7 → 473
    M20_dipept_like_CNDP; M20 cytosolic nonspecific dipeptidases including anserinase and serum carnosinase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    80314799..80331900 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006254999.5 → XP_006255061.1  cytosolic non-specific dipeptidase isoform X1

    See identical proteins and their annotated locations for XP_006255061.1

    UniProtKB/Swiss-Prot
    Q6Q0N1
    UniProtKB/TrEMBL
    A6K5L5
    Conserved Domains (2) summary
    PRK08201
    Location:3 → 473
    PRK08201; hypothetical protein; Provisional
    cd05676
    Location:7 → 473
    M20_dipept_like_CNDP; M20 cytosolic nonspecific dipeptidases including anserinase and serum carnosinase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6Q0N1.1 GenPept UniProtKB/Swiss-Prot:Q6Q0N1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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