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Ctdp1 CTD phosphatase subunit 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 291414, updated on 27-Nov-2024

Summary

Official Symbol
Ctdp1provided by RGD
Official Full Name
CTD phosphatase subunit 1provided by RGD
Primary source
RGD:1311755
See related
EnsemblRapid:ENSRNOG00000061474 AllianceGenome:RGD:1311755
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable RNA polymerase II CTD heptapeptide repeat phosphatase activity; TFIIF-class transcription factor complex binding activity; and Tat protein binding activity. Involved in negative regulation of cell growth involved in cardiac muscle cell development. Predicted to be located in microtubule cytoskeleton; midbody; and nucleoplasm. Predicted to be part of protein-containing complex. Orthologous to human CTDP1 (CTD phosphatase subunit 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 140.0), Thymus (RPKM 116.7) and 9 other tissues See more
Orthologs
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Genomic context

See Ctdp1 in Genome Data Viewer
Location:
18q12.3
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (76129243..76193404, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (73854277..73916232, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (76922913..76985095, complement)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120098179 Neighboring gene potassium voltage-gated channel modifier subfamily G member 2 Neighboring gene uncharacterized LOC134482964 Neighboring gene uncharacterized LOC103694249 Neighboring gene uncharacterized LOC134482963 Neighboring gene nuclear factor of activated T-cells 1 Neighboring gene ATPase phospholipid transporting 9B (putative) Neighboring gene uncharacterized LOC134482965

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Gene Ontology Provided by RGD

Component Evidence Code Pubs
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in midbody ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
located_in spindle ISO
Inferred from Sequence Orthology
more info
 
located_in spindle midzone ISO
Inferred from Sequence Orthology
more info
 
located_in spindle pole ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
RNA polymerase II subunit A C-terminal domain phosphatase
Names
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
NP_001401324.1
XP_006255005.1
XP_006255006.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001414395.1NP_001401324.1  RNA polymerase II subunit A C-terminal domain phosphatase

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    Related
    ENSRNOP00000071476.1, ENSRNOT00000089122.3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    76129243..76193404 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006254943.5XP_006255005.1  RNA polymerase II subunit A C-terminal domain phosphatase isoform X1

    UniProtKB/TrEMBL
    A0A0G2K0J7, A0A8I6G995
    Related
    ENSRNOP00000083609.1, ENSRNOT00000096477.2
    Conserved Domains (4) summary
    TIGR02250
    Location:234380
    FCP1_euk; FCP1-like phosphatase, phosphatase domain
    cd06850
    Location:78168
    biotinyl_domain; The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, ...
    cd00027
    Location:707776
    BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
    pfam09309
    Location:776867
    FCP1_C; FCP1, C-terminal
  2. XM_006254944.5XP_006255006.1  RNA polymerase II subunit A C-terminal domain phosphatase isoform X2

    UniProtKB/TrEMBL
    A0A0G2K0J7
    Conserved Domains (4) summary
    TIGR02250
    Location:234380
    FCP1_euk; FCP1-like phosphatase, phosphatase domain
    cd06850
    Location:78168
    biotinyl_domain; The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, ...
    cd00027
    Location:707776
    BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
    pfam09309
    Location:776866
    FCP1_C; FCP1, C-terminal

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001106131.1: Suppressed sequence

    Description
    NM_001106131.1: This RefSeq was removed because currently there is insufficient support for the transcript.