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Cxxc1 CXXC finger protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 291440, updated on 27-Nov-2024

Summary

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Official Symbol
Cxxc1provided by RGD
Official Full Name
CXXC finger protein 1provided by RGD
Primary source
RGD:1310755
See related
EnsemblRapid:ENSRNOG00000014614 AllianceGenome:RGD:1310755
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in positive regulation of DNA-templated transcription. Predicted to be located in cytosol; nuclear matrix; and nuclear speck. Predicted to be part of Set1C/COMPASS complex. Orthologous to human CXXC1 (CXXC finger protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 121.1), Adrenal (RPKM 92.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cxxc1 in Genome Data Viewer
Location:
18q12.2
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (70088407..70093786)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (67813185..67818556)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (70192520..70197871)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene spindle and kinetochore associated complex subunit 1 Neighboring gene ribosomal protein S17, pseudogene 3 Neighboring gene methyl-CpG binding domain protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Expression of Na+-K+ -2Cl- cotransporter 1 is epigenetically regulated during postnatal development of hypertension. Cho HM, et al. Am J Hypertens, 2011 Dec. PMID 21814290
  2. Cloning of a mammalian transcriptional activator that binds unmethylated CpG motifs and shares a CXXC domain with DNA methyltransferase, human trithorax, and methyl-CpG binding domain protein 1. Voo KS, et al. Mol Cell Biol, 2000 Mar. PMID 10688657, Free PMC Article
  3. CpG-binding protein is a nuclear matrix- and euchromatin-associated protein localized to nuclear speckles containing human trithorax. Identification of nuclear matrix targeting signals. Lee JH, et al. J Biol Chem, 2002 Nov 1. PMID 12200428
  4. CXXC1 is not essential for normal DNA double-strand break formation and meiotic recombination in mouse. Tian H, et al. PLoS Genet, 2018 Oct. PMID 30365547, Free PMC Article
  5. ZF-CxxC domain-containing proteins, CpG islands and the chromatin connection. Long HK, et al. Biochem Soc Trans, 2013 Jun. PMID 23697932, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables methylated histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables methylated histone binding ISO
Inferred from Sequence Orthology
more info
  
enables unmethylated CpG binding ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in positive regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of Set1C/COMPASS complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Set1C/COMPASS complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
part_of histone methyltransferase complex ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear matrix ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
CXXC-type zinc finger protein 1
Names
CXXC finger 1 (PHD domain)
cpG-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001079698.1 → NP_001073166.1  CXXC-type zinc finger protein 1

    See identical proteins and their annotated locations for NP_001073166.1

    Status: PROVISIONAL

    Source sequence(s)
    BC128781
    UniProtKB/TrEMBL
    A1A5S2, A6KRE4
    Conserved Domains (3) summary
    pfam02008
    Location:167 → 213
    zf-CXXC; CXXC zinc finger domain
    cd15553
    Location:28 → 73
    PHD_Cfp1; PHD finger found in CXXC-type zinc finger protein 1 (Cfp1)
    pfam12269
    Location:406 → 640
    zf-CpG_bind_C; CpG binding protein zinc finger C terminal domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    70088407..70093786
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039096641.2 → XP_038952569.1  CXXC-type zinc finger protein 1 isoform X1

    UniProtKB/TrEMBL
    A6KRE5

  2. XM_006254917.4 → XP_006254979.1  CXXC-type zinc finger protein 1 isoform X3

    UniProtKB/TrEMBL
    A6KRE4
    Related
    ENSRNOP00000020472.6, ENSRNOT00000020472.8
    Conserved Domains (3) summary
    pfam02008
    Location:167 → 213
    zf-CXXC; CXXC zinc finger domain
    cd15553
    Location:28 → 73
    PHD_Cfp1; PHD finger found in CXXC-type zinc finger protein 1 (Cfp1)
    pfam12269
    Location:410 → 644
    zf-CpG_bind_C; CpG binding protein zinc finger C terminal domain

  3. XM_039096642.2 → XP_038952570.1  CXXC-type zinc finger protein 1 isoform X2

    UniProtKB/TrEMBL
    A6KRE5
Nucleotide Protein Strain
Heading Accession and Version

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