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Tmco6 transmembrane and coiled-coil domains 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 291661, updated on 27-Nov-2024

Summary

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Official Symbol
Tmco6provided by RGD
Official Full Name
transmembrane and coiled-coil domains 6provided by RGD
Primary source
RGD:1309263
See related
EnsemblRapid:ENSRNOG00000017718 AllianceGenome:RGD:1309263
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1309263
Summary
Predicted to enable nuclear import signal receptor activity. Predicted to be involved in protein import into nucleus. Orthologous to human TMCO6 (transmembrane and coiled-coil domains 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 71.4), Thymus (RPKM 65.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tmco6 in Genome Data Viewer
Location:
18p11
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (28623269..28629864)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (28349248..28355843)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (29579145..29585740)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L17, pseudogene 9 Neighboring gene CD14 molecule Neighboring gene NADH:ubiquinone oxidoreductase subunit A2 Neighboring gene IK cytokine Neighboring gene WD repeat domain 55 Neighboring gene DND microRNA-mediated repression inhibitor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables nuclear import signal receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein import into nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transmembrane and coiled-coil domain-containing protein 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106154.1 → NP_001099624.1  transmembrane and coiled-coil domain-containing protein 6

    See identical proteins and their annotated locations for NP_001099624.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473974
    UniProtKB/TrEMBL
    A6J328, B2RYM7, G3V979
    Related
    ENSRNOP00000038714.4, ENSRNOT00000038066.6
    Conserved Domains (3) summary
    COG5064
    Location:23 → 391
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    cd00020
    Location:104 → 218
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    sd00043
    Location:104 → 135
    ARM; armadillo repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    28623269..28629864
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063277214.1 → XP_063133284.1  transmembrane and coiled-coil domain-containing protein 6 isoform X1

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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