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Cxxc5 CXXC finger protein 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 291670, updated on 4-Jan-2025

Summary

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Official Symbol
Cxxc5provided by RGD
Official Full Name
CXXC finger protein 5provided by RGD
Primary source
RGD:1359466
See related
EnsemblRapid:ENSRNOG00000032878 AllianceGenome:RGD:1359466
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable DNA-binding transcription factor binding activity; methyl-CpG binding activity; and zinc ion binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; positive regulation of canonical NF-kappaB signal transduction; and regulation of generation of precursor metabolites and energy. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Orthologous to human CXXC5 (CXXC finger protein 5). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Kidney (RPKM 232.3), Thymus (RPKM 143.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cxxc5 in Genome Data Viewer
Location:
18p11
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (27701650..27732633)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (27427591..27458579)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (28626386..28656916)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120098144 Neighboring gene ubiquitin-conjugating enzyme E2D 2 Neighboring gene U6atac minor spliceosomal RNA Neighboring gene uncharacterized LOC134482928 Neighboring gene ribosomal protein S16, pseudogene 2 Neighboring gene uncharacterized LOC134483007 Neighboring gene uncharacterized LOC134483008

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. CXXC5 is a novel BMP4-regulated modulator of Wnt signaling in neural stem cells. Andersson T, et al. J Biol Chem, 2009 Feb 6. PMID 19001364
  2. Oxygen-dependent expression of cytochrome c oxidase subunit 4-2 gene expression is mediated by transcription factors RBPJ, CXXC5 and CHCHD2. Aras S, et al. Nucleic Acids Res, 2013 Feb 1. PMID 23303788, Free PMC Article
  3. DNA Sequence Recognition of Human CXXC Domains and Their Structural Determinants. Xu C, et al. Structure, 2018 Jan 2. PMID 29276034
  4. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. Matsuda A, et al. Oncogene, 2003 May 22. PMID 12761501
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC94398

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables methyl-CpG binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables methyl-CpG binding ISO
Inferred from Sequence Orthology
more info
  
enables methyl-CpG binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in regulation of generation of precursor metabolites and energy ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
CXXC-type zinc finger protein 5
Names
CXXC finger 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007628.2 → NP_001007629.1  CXXC-type zinc finger protein 5

    See identical proteins and their annotated locations for NP_001007629.1

    Status: VALIDATED

    Source sequence(s)
    BC083622, BE114271, DV723039
    UniProtKB/Swiss-Prot
    Q5XIQ3
    UniProtKB/TrEMBL
    A6J2Z8
    Conserved Domains (1) summary
    pfam02008
    Location:249 → 290
    zf-CXXC; CXXC zinc finger domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    27701650..27732633
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039096716.2 → XP_038952644.1  CXXC-type zinc finger protein 5 isoform X1

    UniProtKB/Swiss-Prot
    Q5XIQ3
    UniProtKB/TrEMBL
    A6J2Z8
    Conserved Domains (1) summary
    pfam02008
    Location:249 → 290
    zf-CXXC; CXXC zinc finger domain

  2. XM_039096715.2 → XP_038952643.1  CXXC-type zinc finger protein 5 isoform X1

    UniProtKB/Swiss-Prot
    Q5XIQ3
    UniProtKB/TrEMBL
    A6J2Z8
    Conserved Domains (1) summary
    pfam02008
    Location:249 → 290
    zf-CXXC; CXXC zinc finger domain

  3. XM_039096713.2 → XP_038952641.1  CXXC-type zinc finger protein 5 isoform X1

    UniProtKB/Swiss-Prot
    Q5XIQ3
    UniProtKB/TrEMBL
    A6J2Z8
    Related
    ENSRNOP00000042976.2, ENSRNOT00000045795.4
    Conserved Domains (1) summary
    pfam02008
    Location:249 → 290
    zf-CXXC; CXXC zinc finger domain

  4. XM_039096714.2 → XP_038952642.1  CXXC-type zinc finger protein 5 isoform X1

    UniProtKB/Swiss-Prot
    Q5XIQ3
    UniProtKB/TrEMBL
    A6J2Z8
    Conserved Domains (1) summary
    pfam02008
    Location:249 → 290
    zf-CXXC; CXXC zinc finger domain

  5. XM_039096712.2 → XP_038952640.1  CXXC-type zinc finger protein 5 isoform X1

    UniProtKB/Swiss-Prot
    Q5XIQ3
    UniProtKB/TrEMBL
    A6J2Z8
    Conserved Domains (1) summary
    pfam02008
    Location:249 → 290
    zf-CXXC; CXXC zinc finger domain

  6. XM_039096711.1 → XP_038952639.1  CXXC-type zinc finger protein 5 isoform X1

    UniProtKB/Swiss-Prot
    Q5XIQ3
    UniProtKB/TrEMBL
    A6J2Z8
    Conserved Domains (1) summary
    pfam02008
    Location:249 → 290
    zf-CXXC; CXXC zinc finger domain

  7. XM_017600904.3 → XP_017456393.1  CXXC-type zinc finger protein 5 isoform X1

    UniProtKB/Swiss-Prot
    Q5XIQ3
    UniProtKB/TrEMBL
    A6J2Z8
    Conserved Domains (1) summary
    pfam02008
    Location:249 → 290
    zf-CXXC; CXXC zinc finger domain

  8. XM_017600900.3 → XP_017456389.1  CXXC-type zinc finger protein 5 isoform X1

    UniProtKB/Swiss-Prot
    Q5XIQ3
    UniProtKB/TrEMBL
    A6J2Z8
    Conserved Domains (1) summary
    pfam02008
    Location:249 → 290
    zf-CXXC; CXXC zinc finger domain

  9. XM_017600902.3 → XP_017456391.1  CXXC-type zinc finger protein 5 isoform X1

    UniProtKB/Swiss-Prot
    Q5XIQ3
    UniProtKB/TrEMBL
    A6J2Z8
    Conserved Domains (1) summary
    pfam02008
    Location:249 → 290
    zf-CXXC; CXXC zinc finger domain

  10. XM_063277216.1 → XP_063133286.1  CXXC-type zinc finger protein 5 isoform X2

    UniProtKB/TrEMBL
    A0A8I6AID9
    Related
    ENSRNOP00000094752.1, ENSRNOT00000104184.2

  11. XM_063277215.1 → XP_063133285.1  CXXC-type zinc finger protein 5 isoform X1

    UniProtKB/Swiss-Prot
    Q5XIQ3
    UniProtKB/TrEMBL
    A6J2Z8

  12. XM_017600903.3 → XP_017456392.1  CXXC-type zinc finger protein 5 isoform X1

    UniProtKB/Swiss-Prot
    Q5XIQ3
    UniProtKB/TrEMBL
    A6J2Z8
    Conserved Domains (1) summary
    pfam02008
    Location:249 → 290
    zf-CXXC; CXXC zinc finger domain

RNA

  1. XR_005496008.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5XIQ3.1 GenPept UniProtKB/Swiss-Prot:Q5XIQ3

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