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Cdh10 cadherin 10 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29181, updated on 27-Nov-2024

Summary

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Official Symbol
Cdh10provided by RGD
Official Full Name
cadherin 10provided by RGD
Primary source
RGD:619741
See related
EnsemblRapid:ENSRNOG00000009771 AllianceGenome:RGD:619741
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable beta-catenin binding activity and cadherin binding activity. Predicted to be involved in several processes, including calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; cell-cell adhesion mediated by cadherin; and cell-cell junction organization. Is active in GABA-ergic synapse; glutamatergic synapse; and synaptic membrane. Orthologous to human CDH10 (cadherin 10). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward (RPKM 120.0) See more
Orthologs
human mouse all
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Genomic context

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See Cdh10 in Genome Data Viewer
Location:
2q21
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (70355521..70577880)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (68628623..68850995)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (69415174..69636849)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene protein crumbs homolog 3-like Neighboring gene 60S ribosomal protein L6-like Neighboring gene uncharacterized LOC120100745 Neighboring gene uncharacterized LOC120100746 Neighboring gene RB binding protein 9, serine hydrolase, pseudogene 1 Neighboring gene uncharacterized LOC102553625 Neighboring gene uncharacterized LOC102553734 Neighboring gene uncharacterized LOC120100560

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Cadherin-10 Maintains Excitatory/Inhibitory Ratio through Interactions with Synaptic Proteins. Smith KR, et al. J Neurosci, 2017 Nov 15. PMID 29030434, Free PMC Article
  2. Multiple cadherin superfamily members with unique expression profiles are produced in rat testis. Johnson KJ, et al. Endocrinology, 2000 Feb. PMID 10650949
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cadherin-10 forms nanoscale puncta at excitatory and inhibitory synapses in neuronal dendrites.
    Title: Cadherin-10 Maintains Excitatory/Inhibitory Ratio through Interactions with Synaptic Proteins.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables beta-catenin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cadherin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in adherens junction organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-cell adhesion TAS
Traceable Author Statement
more info
 PubMed 
involved_in cell-cell adhesion mediated by cadherin IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-cell junction assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
Inferred from Electronic Annotation
more info
  
involved_in synaptic membrane adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in synaptic membrane adhesion ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in GABA-ergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in adherens junction IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of catenin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic specialization membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in presynaptic active zone membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in synapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cadherin-10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001168631.1 → NP_001162102.1  cadherin-10 precursor

    See identical proteins and their annotated locations for NP_001162102.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    A6JMU7, F1LR98
    Conserved Domains (3) summary
    cd11304
    Location:164 → 265
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:80 → 158
    CA; Cadherin repeats
    pfam01049
    Location:643 → 780
    Cadherin_C; Cadherin cytoplasmic region

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    70355521..70577880
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006232080.5 → XP_006232142.1  cadherin-10 isoform X2

    UniProtKB/TrEMBL
    A6JMU7
    Related
    ENSRNOP00000013152.2, ENSRNOT00000013152.6
    Conserved Domains (3) summary
    cd11304
    Location:164 → 265
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:80 → 158
    CA; Cadherin repeats
    pfam01049
    Location:641 → 778
    Cadherin_C; Cadherin cytoplasmic region

  2. XM_006232079.5 → XP_006232141.1  cadherin-10 isoform X1

    See identical proteins and their annotated locations for XP_006232141.1

    UniProtKB/TrEMBL
    A6JMU7, F1LR98
    Conserved Domains (3) summary
    cd11304
    Location:164 → 265
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:80 → 158
    CA; Cadherin repeats
    pfam01049
    Location:643 → 780
    Cadherin_C; Cadherin cytoplasmic region
Nucleotide Protein Strain
Heading Accession and Version

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