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Slc38a7 solute carrier family 38, member 7 [ Rattus norvegicus (Norway rat) ]

Gene ID: 291840, updated on 27-Nov-2024

Summary

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Official Symbol
Slc38a7provided by RGD
Official Full Name
solute carrier family 38, member 7provided by RGD
Primary source
RGD:1303268
See related
EnsemblRapid:ENSRNOG00000012007 AllianceGenome:RGD:1303268
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable L-asparagine:sodium symporter activity and L-glutamine:sodium symporter activity. Predicted to be involved in amino acid transmembrane transport; neutral amino acid transport; and sodium ion transport. Predicted to be located in axon; lysosomal membrane; and neuronal cell body. Predicted to be active in membrane. Orthologous to human SLC38A7 (solute carrier family 38 member 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 67.2), Liver (RPKM 37.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Slc38a7 in Genome Data Viewer
Location:
19p13
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (9215336..9231592)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (9209203..9225472)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (9622594..9638221)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120098551 Neighboring gene glutamic-oxaloacetic transaminase 2 Neighboring gene uncharacterized LOC102548468 Neighboring gene CCR4-NOT transcription complex, subunit 1 Neighboring gene small nucleolar RNA SNORA50

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification of SLC38A7 (SNAT7) protein as a glutamine transporter expressed in neurons. Hägglund MG, et al. J Biol Chem, 2011 Jun 10. PMID 21511949, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Clone Names

  • MGC105833

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables L-asparagine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-asparagine:sodium symporter activity ISO
Inferred from Sequence Orthology
more info
  
enables L-asparagine:sodium symporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables L-glutamine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-glutamine:sodium symporter activity ISO
Inferred from Sequence Orthology
more info
  
enables L-glutamine:sodium symporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in amino acid transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in asparagine transport ISO
Inferred from Sequence Orthology
more info
  
involved_in asparagine transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in glutamine transport ISO
Inferred from Sequence Orthology
more info
  
involved_in glutamine transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in inorganic cation transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic cation transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in sodium ion transport ISO
Inferred from Sequence Orthology
more info
  
involved_in sodium ion transport ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in axon ISO
Inferred from Sequence Orthology
more info
  
located_in axon ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
  
located_in lysosomal membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
located_in neuronal cell body ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
sodium-coupled neutral amino acid transporter 7
Names
amino acid transporter
putative sodium-coupled neutral amino acid transporter 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003705.3 → NP_001003705.1  sodium-coupled neutral amino acid transporter 7

    See identical proteins and their annotated locations for NP_001003705.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000019
    UniProtKB/Swiss-Prot
    Q6JWR2
    UniProtKB/TrEMBL
    A6JXZ0
    Conserved Domains (1) summary
    cl00456
    Location:49 → 458
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  2. NM_001434001.1 → NP_001420930.1  sodium-coupled neutral amino acid transporter 7

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000019

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    9215336..9231592
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006255067.4 → XP_006255129.1  sodium-coupled neutral amino acid transporter 7 isoform X1

    UniProtKB/Swiss-Prot
    Q6JWR2
    UniProtKB/TrEMBL
    A6JXZ0
    Related
    ENSRNOP00000058216.1, ENSRNOT00000061498.5
    Conserved Domains (1) summary
    cl00456
    Location:49 → 458
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  2. XM_063277841.1 → XP_063133911.1  sodium-coupled neutral amino acid transporter 7 isoform X2

  3. XM_063277842.1 → XP_063133912.1  sodium-coupled neutral amino acid transporter 7 isoform X3

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6JWR2.1 GenPept UniProtKB/Swiss-Prot:Q6JWR2

Gene LinkOut

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