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Katnb1 katanin regulatory subunit B1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 291852, updated on 27-Nov-2024

Summary

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Official Symbol
Katnb1provided by RGD
Official Full Name
katanin regulatory subunit B1provided by RGD
Primary source
RGD:1311256
See related
EnsemblRapid:ENSRNOG00000014626 AllianceGenome:RGD:1311256
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ATPase regulator activity; dynein complex binding activity; and protein heterodimerization activity. Involved in microtubule severing; positive regulation of apoptotic process; and positive regulation of neuron projection development. Located in growth cone; midbody; and neuronal cell body. Human ortholog(s) of this gene implicated in lissencephaly 6. Orthologous to human KATNB1 (katanin regulatory subunit B1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Testes (RPKM 230.2), Brain (RPKM 84.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Katnb1 in Genome Data Viewer
Location:
19p13
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (9927249..9946750, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (9921216..9940853, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (10340027..10360319, complement)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene cyclic nucleotide gated channel subunit beta 1 Neighboring gene RNA, U2 small nuclear 69, pseudogene Neighboring gene kinesin family member C3 Neighboring gene uncharacterized LOC134483686 Neighboring gene dynein regulatory complex subunit 7 Neighboring gene adhesion G protein-coupled receptor G3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. LAPSER1 is a putative cytokinetic tumor suppressor that shows the same centrosome and midbody subcellular localization pattern as p80 katanin. Sudo H, et al. FASEB J, 2007 Jul. PMID 17351128
  2. Regulation of microtubule severing by katanin subunits during neuronal development. Yu W, et al. J Neurosci, 2005 Jun 8. PMID 15944385, Free PMC Article
  3. Two domains of p80 katanin regulate microtubule severing and spindle pole targeting by p60 katanin. McNally KP, et al. J Cell Sci, 2000 May. PMID 10751153
  4. Katanin, a microtubule-severing protein, is a novel AAA ATPase that targets to the centrosome using a WD40-containing subunit. Hartman JJ, et al. Cell, 1998 Apr 17. PMID 9568719
  5. Proteomic Analysis of the Mammalian Katanin Family of Microtubule-severing Enzymes Defines Katanin p80 subunit B-like 1 (KATNBL1) as a Regulator of Mammalian Katanin Microtubule-severing. Cheung K, et al. Mol Cell Proteomics, 2016 May. PMID 26929214, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATPase regulator activity ISO
Inferred from Sequence Orthology
more info
  
enables dynein complex binding ISO
Inferred from Sequence Orthology
more info
  
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in microtubule depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule severing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mitotic chromosome movement towards spindle pole IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of microtubule depolymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of microtubule depolymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of neuron projection development IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
located_in axon ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in growth cone IDA
Inferred from Direct Assay
more info
 PubMed 
part_of katanin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of katanin complex ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in midbody IDA
Inferred from Direct Assay
more info
 PubMed 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in spindle ISO
Inferred from Sequence Orthology
more info
  
located_in spindle pole ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
katanin p80 WD40 repeat-containing subunit B1
Names
katanin p80 (WD repeat containing) subunit B 1
katanin p80 (WD40-containing) subunit B 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024746.2 → NP_001019917.1  katanin p80 WD40 repeat-containing subunit B1

    See identical proteins and their annotated locations for NP_001019917.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000019
    UniProtKB/TrEMBL
    B1WBN6, Q4VFZ4
    Conserved Domains (4) summary
    PRK14951
    Location:386 → 494
    PRK14951; DNA polymerase III subunits gamma and tau; Provisional
    cd00200
    Location:7 → 257
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:67 → 103
    7WD40; WD40 repeat [structural motif]
    pfam13925
    Location:497 → 648
    Katanin_con80; con80 domain of Katanin

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    9927249..9946750 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063277855.1 → XP_063133925.1  katanin p80 WD40 repeat-containing subunit B1 isoform X4

  2. XM_017601201.3 → XP_017456690.1  katanin p80 WD40 repeat-containing subunit B1 isoform X2

    UniProtKB/TrEMBL
    B1WBN6
    Conserved Domains (3) summary
    cd00200
    Location:7 → 257
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:67 → 103
    7WD40; WD40 repeat [structural motif]
    pfam13925
    Location:496 → 651
    Katanin_con80; con80 domain of Katanin

  3. XM_017601198.3 → XP_017456687.1  katanin p80 WD40 repeat-containing subunit B1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JX20, B1WBN6
    Related
    ENSRNOP00000070102.2, ENSRNOT00000087100.3
    Conserved Domains (4) summary
    PRK14951
    Location:386 → 494
    PRK14951; DNA polymerase III subunits gamma and tau; Provisional
    cd00200
    Location:7 → 257
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:67 → 103
    7WD40; WD40 repeat [structural motif]
    pfam13925
    Location:497 → 652
    Katanin_con80; con80 domain of Katanin

  4. XM_063277854.1 → XP_063133924.1  katanin p80 WD40 repeat-containing subunit B1 isoform X3

    UniProtKB/TrEMBL
    Q4VFZ4

  5. XM_063277852.1 → XP_063133922.1  katanin p80 WD40 repeat-containing subunit B1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JX20

  6. XM_063277856.1 → XP_063133926.1  katanin p80 WD40 repeat-containing subunit B1 isoform X4

  7. XM_063277853.1 → XP_063133923.1  katanin p80 WD40 repeat-containing subunit B1 isoform X3

    UniProtKB/TrEMBL
    Q4VFZ4

  8. XM_017601200.3 → XP_017456689.1  katanin p80 WD40 repeat-containing subunit B1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JX20, B1WBN6
    Conserved Domains (4) summary
    PRK14951
    Location:386 → 494
    PRK14951; DNA polymerase III subunits gamma and tau; Provisional
    cd00200
    Location:7 → 257
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:67 → 103
    7WD40; WD40 repeat [structural motif]
    pfam13925
    Location:497 → 652
    Katanin_con80; con80 domain of Katanin
Nucleotide Protein Strain
Heading Accession and Version

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