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Adgrg3 adhesion G protein-coupled receptor G3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 291854, updated on 27-Nov-2024

Summary

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Official Symbol
Adgrg3provided by RGD
Official Full Name
adhesion G protein-coupled receptor G3provided by RGD
Primary source
RGD:1305674
See related
EnsemblRapid:ENSRNOG00000014896 AllianceGenome:RGD:1305674
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Gpr97
Summary
Predicted to enable G protein-coupled receptor activity. Predicted to be involved in several processes, including adenylate cyclase-activating G protein-coupled receptor signaling pathway; negative regulation of CREB transcription factor activity; and negative regulation of non-canonical NF-kappaB signal transduction. Predicted to be active in plasma membrane. Orthologous to human ADGRG3 (adhesion G protein-coupled receptor G3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 11.6), Spleen (RPKM 8.4) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Adgrg3 in Genome Data Viewer
Location:
19p13
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (9978450..10007145, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (9972425..10001118, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (10392001..10422606, complement)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene katanin regulatory subunit B1 Neighboring gene dynein regulatory complex subunit 7 Neighboring gene adhesion G protein-coupled receptor G1 Neighboring gene adhesion G protein-coupled receptor G5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Gpr97 is essential for the follicular versus marginal zone B-lymphocyte fate decision. Wang JJ, et al. Cell Death Dis, 2013 Oct 10. PMID 24113187, Free PMC Article
  2. Signaling property study of adhesion G-protein-coupled receptors. Gupte J, et al. FEBS Lett, 2012 Apr 24. PMID 22575658
  3. The orphan adhesion G protein-coupled receptor GPR97 regulates migration of lymphatic endothelial cells via the small GTPases RhoA and Cdc42. Valtcheva N, et al. J Biol Chem, 2013 Dec 13. PMID 24178298, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in B cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of CREB transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of non-canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
probable G-protein coupled receptor 97; adhesion G protein-coupled receptor G3
Names
G protein-coupled receptor 97

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001430216.1 → NP_001417145.1  probable G-protein coupled receptor 97 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000019
    UniProtKB/TrEMBL
    A0A0G2JSN6

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    9978450..10007145 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006255127.5 → XP_006255189.1  adhesion G protein-coupled receptor G3 isoform X4

    See identical proteins and their annotated locations for XP_006255189.1

    UniProtKB/TrEMBL
    A6JY31
    Related
    ENSRNOP00000078552.2, ENSRNOT00000105448.2
    Conserved Domains (2) summary
    pfam01825
    Location:167 → 206
    GPS; GPCR proteolysis site, GPS, motif
    cl21561
    Location:216 → 465
    7tm_4; Olfactory receptor

  2. XM_006255126.5 → XP_006255188.1  adhesion G protein-coupled receptor G3 isoform X2

    Related
    ENSRNOP00000020062.5, ENSRNOT00000020062.9
    Conserved Domains (2) summary
    pfam01825
    Location:216 → 255
    GPS; GPCR proteolysis site, GPS, motif
    cl21561
    Location:265 → 514
    7tm_4; Olfactory receptor

  3. XM_039098149.1 → XP_038954077.1  adhesion G protein-coupled receptor G3 isoform X3

    UniProtKB/TrEMBL
    A6JY31
    Conserved Domains (3) summary
    pfam01825
    Location:195 → 233
    GPS; GPCR proteolysis site, GPS, motif
    cd14964
    Location:245 → 270
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:243 → 502
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  4. XM_039098148.1 → XP_038954076.1  adhesion G protein-coupled receptor G3 isoform X1

    UniProtKB/TrEMBL
    A6JY31
    Conserved Domains (3) summary
    pfam01825
    Location:244 → 282
    GPS; GPCR proteolysis site, GPS, motif
    cd14964
    Location:294 → 319
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:292 → 551
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
Nucleotide Protein Strain
Heading Accession and Version

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