U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Nlrc5 NLR family, CARD domain containing 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 291861, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Symbol
Nlrc5provided by RGD
Full Name
NLR family, CARD domain containing 5provided by RGD
Primary source
RGD:1309166
See related
EnsemblRapid:ENSRNOG00000048222 AllianceGenome:RGD:1309166
Gene type
protein coding
RefSeq status
MODEL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Cpne2
Summary
Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including innate immune response; regulation of cytokine-mediated signaling pathway; and regulation of macromolecule biosynthetic process. Predicted to act upstream of or within response to bacterium. Predicted to be located in centrosome and cytosol. Predicted to be active in nucleus. Orthologous to human NLRC5 (NLR family CARD domain containing 5). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Spleen (RPKM 83.8), Thymus (RPKM 74.7) and 8 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Nlrc5 in Genome Data Viewer
Location:
19p13
Exon count:
53
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (10483601..10587223, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (10477638..10581023, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (10904381..11006202, complement)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483687 Neighboring gene copine 2 Neighboring gene uncharacterized LOC134483689 Neighboring gene 60S ribosomal protein L36 pseudogene Neighboring gene uncharacterized LOC134483688 Neighboring gene homocysteine inducible ER protein with ubiquitin like domain 1 Neighboring gene uncharacterized LOC102553339 Neighboring gene uncharacterized LOC120098571 Neighboring gene solute carrier family 12 member 3

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Long noncoding RNA MEG3 regulates rheumatoid arthritis by targeting NLRC5. Liu YR, et al. J Cell Physiol, 2019 Aug. PMID 30644097
  2. NLRC5 promotes cell proliferation via regulating the NF-κB signaling pathway in Rheumatoid arthritis. Liu YR, et al. Mol Immunol, 2017 Nov. PMID 28865311
  3. NLRC5 silencing ameliorates cardiac fibrosis by inhibiting the TGF‑β1/Smad3 signaling pathway. Zhou H, et al. Mol Med Rep, 2017 Sep. PMID 28713900
  4. The nucleotide-binding oligomerization domain-like receptor NLRC5 is involved in IFN-dependent antiviral immune responses. Kuenzel S, et al. J Immunol, 2010 Feb 15. PMID 20061403
  5. NLRC5 protects neurons from oxygen-glucose deprivation-induced injury through activating the Nrf2/HO-1 pathway. Li L, et al. J Recept Signal Transduct Res, 2021 Feb. PMID 32605461

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NLRC5 protects neurons from oxygen-glucose deprivation-induced injury through activating the Nrf2/HO-1 pathway.
    Title: NLRC5 protects neurons from oxygen-glucose deprivation-induced injury through activating the Nrf2/HO-1 pathway.
  2. The level of MEG3 significantly reduced in CFA-induced synovial tissues and Fibroblast-like synoviocytes (FLSs), whereas the NLRC5 levels were increased. Enforced expression of MEG3 may be responsible for the decreased level of NLRC5 and inflammatory cytokine level
    Title: Long noncoding RNA MEG3 regulates rheumatoid arthritis by targeting NLRC5.
  3. NLRC5 silencing ameliorated cardiac fibrosis by inhibiting the TGFbeta1/Smad3 signaling pathway.
    Title: NLRC5 silencing ameliorates cardiac fibrosis by inhibiting the TGF‑β1/Smad3 signaling pathway.
  4. These results suggested that NLRC5 promotes Rheumatoid arthritis progression via the NF-kappaB signaling pathway potentially.
    Title: NLRC5 promotes cell proliferation via regulating the NF-κB signaling pathway in Rheumatoid arthritis.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in defense response to virus IEA
Inferred from Electronic Annotation
more info
  
involved_in innate immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of type I interferon-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of type I interferon-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of MHC class I biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of MHC class I biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of type I interferon-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of type II interferon-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of kinase activity ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to bacterium ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
NLR family, CARD domain containing 5; protein NLRC5
Names
copine II
protein NLRC5-like

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    10483601..10587223 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039098152.2 → XP_038954080.1  protein NLRC5 isoform X1

    UniProtKB/TrEMBL
    M0R4M1
    Conserved Domains (6) summary
    sd00033
    Location:1526 → 1553
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:1442 → 1466
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam05729
    Location:224 → 387
    NACHT; NACHT domain
    pfam17776
    Location:520 → 635
    NLRC4_HD2; NLRC4 helical domain HD2
    pfam18461
    Location:1 → 94
    Atypical_Card; Atypical caspase recruitment domain
    cl39015
    Location:1497 → 1807
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

  2. XM_039098155.2 → XP_038954083.1  protein NLRC5 isoform X1

    UniProtKB/TrEMBL
    M0R4M1
    Conserved Domains (6) summary
    sd00033
    Location:1526 → 1553
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:1442 → 1466
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam05729
    Location:224 → 387
    NACHT; NACHT domain
    pfam17776
    Location:520 → 635
    NLRC4_HD2; NLRC4 helical domain HD2
    pfam18461
    Location:1 → 94
    Atypical_Card; Atypical caspase recruitment domain
    cl39015
    Location:1497 → 1807
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

  3. XM_039098156.2 → XP_038954084.1  protein NLRC5 isoform X1

    UniProtKB/TrEMBL
    M0R4M1
    Conserved Domains (6) summary
    sd00033
    Location:1526 → 1553
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:1442 → 1466
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam05729
    Location:224 → 387
    NACHT; NACHT domain
    pfam17776
    Location:520 → 635
    NLRC4_HD2; NLRC4 helical domain HD2
    pfam18461
    Location:1 → 94
    Atypical_Card; Atypical caspase recruitment domain
    cl39015
    Location:1497 → 1807
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

  4. XM_039098158.2 → XP_038954086.1  protein NLRC5 isoform X3

    Related
    ENSRNOP00000107072.1, ENSRNOT00000160769.1
    Conserved Domains (6) summary
    sd00033
    Location:1470 → 1497
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:1386 → 1410
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam05729
    Location:224 → 387
    NACHT; NACHT domain
    pfam17776
    Location:520 → 635
    NLRC4_HD2; NLRC4 helical domain HD2
    pfam18461
    Location:1 → 94
    Atypical_Card; Atypical caspase recruitment domain
    cl39015
    Location:1441 → 1751
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

  5. XM_039098157.2 → XP_038954085.1  protein NLRC5 isoform X2

    Related
    ENSRNOP00000064308.4, ENSRNOT00000073239.4
    Conserved Domains (6) summary
    sd00033
    Location:1498 → 1525
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:1414 → 1438
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam05729
    Location:224 → 387
    NACHT; NACHT domain
    pfam17776
    Location:520 → 635
    NLRC4_HD2; NLRC4 helical domain HD2
    pfam18461
    Location:1 → 94
    Atypical_Card; Atypical caspase recruitment domain
    cl39015
    Location:1469 → 1779
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

  6. XM_039098150.2 → XP_038954078.1  protein NLRC5 isoform X1

    UniProtKB/TrEMBL
    M0R4M1
    Conserved Domains (6) summary
    sd00033
    Location:1526 → 1553
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:1442 → 1466
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam05729
    Location:224 → 387
    NACHT; NACHT domain
    pfam17776
    Location:520 → 635
    NLRC4_HD2; NLRC4 helical domain HD2
    pfam18461
    Location:1 → 94
    Atypical_Card; Atypical caspase recruitment domain
    cl39015
    Location:1497 → 1807
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

  7. XM_039098154.2 → XP_038954082.1  protein NLRC5 isoform X1

    UniProtKB/TrEMBL
    M0R4M1
    Conserved Domains (6) summary
    sd00033
    Location:1526 → 1553
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:1442 → 1466
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam05729
    Location:224 → 387
    NACHT; NACHT domain
    pfam17776
    Location:520 → 635
    NLRC4_HD2; NLRC4 helical domain HD2
    pfam18461
    Location:1 → 94
    Atypical_Card; Atypical caspase recruitment domain
    cl39015
    Location:1497 → 1807
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

  8. XM_039098153.2 → XP_038954081.1  protein NLRC5 isoform X1

    UniProtKB/TrEMBL
    M0R4M1
    Conserved Domains (6) summary
    sd00033
    Location:1526 → 1553
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:1442 → 1466
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam05729
    Location:224 → 387
    NACHT; NACHT domain
    pfam17776
    Location:520 → 635
    NLRC4_HD2; NLRC4 helical domain HD2
    pfam18461
    Location:1 → 94
    Atypical_Card; Atypical caspase recruitment domain
    cl39015
    Location:1497 → 1807
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

  9. XM_063278888.1 → XP_063134958.1  protein NLRC5 isoform X1

    UniProtKB/TrEMBL
    M0R4M1
    Related
    ENSRNOP00000111243.1, ENSRNOT00000142811.1

  10. XM_063278889.1 → XP_063134959.1  protein NLRC5 isoform X4

RNA

  1. XR_005496893.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.