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Tppp3 tubulin polymerization-promoting protein family member 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 291966, updated on 4-Jan-2025

Summary

Official Symbol
Tppp3provided by RGD
Official Full Name
tubulin polymerization-promoting protein family member 3provided by RGD
Primary source
RGD:1305061
See related
EnsemblRapid:ENSRNOG00000016890 AllianceGenome:RGD:1305061
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
CGI-38; RGD1305061
Summary
Predicted to enable tubulin binding activity. Predicted to be involved in several processes, including decidualization; embryo implantation; and microtubule cytoskeleton organization. Predicted to be located in microtubule bundle and perinuclear region of cytoplasm. Predicted to colocalize with microtubule. Orthologous to human TPPP3 (tubulin polymerization promoting protein family member 3). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Lung (RPKM 1569.2), Muscle (RPKM 398.4) and 2 other tissues See more
Orthologs
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Genomic context

See Tppp3 in Genome Data Viewer
Location:
19q12
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (50255809..50259655, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (33345897..33349610, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (37424323..37428075, complement)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene pleckstrin homology and RhoGEF domain containing G4 Neighboring gene potassium channel tetramerization domain containing 19 Neighboring gene leucine rich repeat containing 36 Neighboring gene zinc finger, DHHC-type containing 1 Neighboring gene hydroxysteroid 11-beta dehydrogenase 2

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Clone Names

  • MGC105620

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables tubulin binding IEA
Inferred from Electronic Annotation
more info
 
enables tubulin binding ISO
Inferred from Sequence Orthology
more info
 
enables tubulin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in decidualization ISO
Inferred from Sequence Orthology
more info
 
involved_in decidualization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in embryo implantation ISO
Inferred from Sequence Orthology
more info
 
involved_in embryo implantation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in microtubule bundle formation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in microtubule bundle formation ISO
Inferred from Sequence Orthology
more info
 
involved_in microtubule bundle formation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in microtubule polymerization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in microtubule polymerization IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of protein polymerization IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
colocalizes_with microtubule IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 
located_in microtubule bundle ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
tubulin polymerization-promoting protein family member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009639.1NP_001009639.1  tubulin polymerization-promoting protein family member 3

    See identical proteins and their annotated locations for NP_001009639.1

    Status: PROVISIONAL

    Source sequence(s)
    BC087585
    UniProtKB/Swiss-Prot
    Q5PPN5
    UniProtKB/TrEMBL
    A0A8I6ANX0, A6IYP9
    Related
    ENSRNOP00000022863.4, ENSRNOT00000022863.9
    Conserved Domains (1) summary
    pfam05517
    Location:11166
    p25-alpha

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    50255809..50259655 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006255464.5XP_006255526.1  tubulin polymerization-promoting protein family member 3 isoform X1

    See identical proteins and their annotated locations for XP_006255526.1

    UniProtKB/Swiss-Prot
    Q5PPN5
    UniProtKB/TrEMBL
    A0A8I6ANX0, A6IYP9
    Conserved Domains (1) summary
    pfam05517
    Location:11166
    p25-alpha