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Nob1 NIN1 (RPN12) binding protein 1 homolog [ Rattus norvegicus (Norway rat) ]

Gene ID: 291996, updated on 4-Jan-2025

Summary

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Official Symbol
Nob1provided by RGD
Official Full Name
NIN1 (RPN12) binding protein 1 homologprovided by RGD
Primary source
RGD:735222
See related
EnsemblRapid:ENSRNOG00000021890 AllianceGenome:RGD:735222
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Nob1p
Summary
Predicted to enable RNA endonuclease activity. Predicted to be involved in maturation of SSU-rRNA. Predicted to act upstream of or within visual perception. Predicted to be located in nucleus. Predicted to be part of preribosome, small subunit precursor. Orthologous to human NOB1 (NIN1 (RPN12) binding protein 1 homolog). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Adrenal (RPKM 95.7), Kidney (RPKM 80.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Nob1 in Genome Data Viewer
Location:
19q12
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (52232543..52245824, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (35322803..35335354, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (38397466..38409924)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene nuclear factor of activated T-cells 5 Neighboring gene uncharacterized LOC134483351 Neighboring gene NAD(P)H quinone dehydrogenase 1 Neighboring gene WW domain containing E3 ubiquitin protein ligase 2 Neighboring gene eukaryotic translation initiation factor 5B, pseudogene 1 Neighboring gene microRNA 140

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Up-regulation of Nob1 in the rat auditory system with noise-induced hearing loss. Han Y, et al. Neurosci Lett, 2011 Mar 10. PMID 21219967
  2. Gradual processing of the ITS1 from the nucleolus to the cytoplasm during synthesis of the human 18S rRNA. Preti M, et al. Nucleic Acids Res, 2013 Apr. PMID 23482395, Free PMC Article
  3. Nob1p is required for cleavage of the 3' end of 18S rRNA. Fatica A, et al. Mol Cell Biol, 2003 Mar. PMID 12588997, Free PMC Article
  4. Rod-driven OFF pathway responses in the distal retina: dark-adapted flicker electroretinogram in mouse. Lei B. PLoS One, 2012. PMID 22937111, Free PMC Article
  5. Both endonucleolytic and exonucleolytic cleavage mediate ITS1 removal during human ribosomal RNA processing. Sloan KE, et al. J Cell Biol, 2013 Mar 4. PMID 23439679, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Nob1 may play an important role in auditory function following acoustic trauma.
    Title: Up-regulation of Nob1 in the rat auditory system with noise-induced hearing loss.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC156557

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA endonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA endonuclease activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in maturation of SSU-rRNA IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ribosomal small subunit biogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in visual perception IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within visual perception ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of preribosome, small subunit precursor IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
RNA-binding protein NOB1
Names
NIN1/PSMD8 binding protein 1 homolog
nin one binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199086.1 → NP_954517.1  RNA-binding protein NOB1

    See identical proteins and their annotated locations for NP_954517.1

    Status: PROVISIONAL

    Source sequence(s)
    AY341886
    UniProtKB/Swiss-Prot
    A0JN09, Q6VEU1
    UniProtKB/TrEMBL
    A0A8L2UKR4, A6IZ01
    Related
    ENSRNOP00000031905.4, ENSRNOT00000034386.6
    Conserved Domains (4) summary
    cd09876
    Location:7 → 115
    PIN_Nob1; PIN domain of eukaryotic ribosome assembly factor Nob1 and archaeal UPF0129 protein Ta0041-like homologs
    COG1439
    Location:8 → 299
    Nob1; rRNA maturation endonuclease Nob1 [Translation, ribosomal structure and biogenesis]
    pfam15017
    Location:135 → 218
    AF1Q; Drug resistance and apoptosis regulator
    pfam08772
    Location:258 → 330
    NOB1_Zn_bind; Nin one binding (NOB1) Zn-ribbon like

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    52232543..52245824 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063277929.1 → XP_063133999.1  RNA-binding protein NOB1 isoform X2

  2. XM_063277928.1 → XP_063133998.1  RNA-binding protein NOB1 isoform X1

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6VEU1.1 GenPept UniProtKB/Swiss-Prot:Q6VEU1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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