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Lrp11 LDL receptor related protein 11 [ Rattus norvegicus (Norway rat) ]

Gene ID: 292462, updated on 27-Nov-2024

Summary

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Symbol
Lrp11provided by RGD
Full Name
LDL receptor related protein 11provided by RGD
Primary source
RGD:1308602
See related
EnsemblRapid:ENSRNOG00000014303 AllianceGenome:RGD:1308602
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable phosphoprotein binding activity. Predicted to be involved in several processes, including response to cold; response to immobilization stress; and response to water deprivation. Predicted to be located in membrane. Orthologous to human LRP11 (LDL receptor related protein 11). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 240.7), Kidney (RPKM 133.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Lrp11 in Genome Data Viewer
Location:
1p13
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (3868665..3928513)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (2048307..2108115)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (1702696..1731210)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene feminization of XX and XO animals 1B, pseudogene 1 Neighboring gene retinoic acid early transcript 1L like 2 Neighboring gene ribosomal protein L23a, pseudogene 6 Neighboring gene uncharacterized LOC120098770 Neighboring gene protein-L-isoaspartate (D-aspartate) O-methyltransferase 1 Neighboring gene nucleoporin 43 Neighboring gene large tumor suppressor kinase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Genetic regulatory network analysis reveals that low density lipoprotein receptor-related protein 11 is involved in stress responses in mice. Xu J, et al. Psychiatry Res, 2014 Dec 30. PMID 25262641
  2. Functional specialization of beta-arrestin interactions revealed by proteomic analysis. Xiao K, et al. Proc Natl Acad Sci U S A, 2007 Jul 17. PMID 17620599, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables phosphoprotein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in multicellular organismal response to stress ISO
Inferred from Sequence Orthology
more info
  
involved_in response to cold ISO
Inferred from Sequence Orthology
more info
  
involved_in response to heat ISO
Inferred from Sequence Orthology
more info
  
involved_in response to immobilization stress ISO
Inferred from Sequence Orthology
more info
  
involved_in response to mechanical stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in response to starvation ISO
Inferred from Sequence Orthology
more info
  
involved_in response to water deprivation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
low-density lipoprotein receptor-related protein 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106217.2 → NP_001099687.2  low-density lipoprotein receptor-related protein 11 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    Conserved Domains (3) summary
    smart00765
    Location:68 → 171
    MANEC; The MANEC domain, formerly called MANSC
    cd00112
    Location:293 → 327
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00146
    Location:191 → 279
    PKD; polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    3868665..3928513
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063282919.1 → XP_063138989.1  low-density lipoprotein receptor-related protein 11 isoform X6

  2. XM_039103574.2 → XP_038959502.1  low-density lipoprotein receptor-related protein 11 isoform X1

    UniProtKB/TrEMBL
    F1M753
    Related
    ENSRNOP00000019181.6, ENSRNOT00000019181.7
    Conserved Domains (3) summary
    smart00765
    Location:68 → 171
    MANEC; The MANEC domain, formerly called MANSC
    cd00112
    Location:293 → 327
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00146
    Location:191 → 279
    PKD; polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is ...

  3. XM_039103584.2 → XP_038959512.1  low-density lipoprotein receptor-related protein 11 isoform X3

    Related
    ENSRNOP00000104483.1, ENSRNOT00000127256.1
    Conserved Domains (3) summary
    smart00765
    Location:68 → 171
    MANEC; The MANEC domain, formerly called MANSC
    cd00112
    Location:293 → 327
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00146
    Location:191 → 279
    PKD; polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is ...

  4. XM_039103592.2 → XP_038959520.1  low-density lipoprotein receptor-related protein 11 isoform X4

    Related
    ENSRNOP00000099995.1, ENSRNOT00000132755.1
    Conserved Domains (2) summary
    smart00765
    Location:68 → 171
    MANEC; The MANEC domain, formerly called MANSC
    cd00146
    Location:191 → 279
    PKD; polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is ...

  5. XM_063282917.1 → XP_063138987.1  low-density lipoprotein receptor-related protein 11 isoform X5

  6. XM_063282916.1 → XP_063138986.1  low-density lipoprotein receptor-related protein 11 isoform X2

Nucleotide Protein Strain
Heading Accession and Version

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