Acvr2a activin A receptor type 2A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Acvr2aprovided by RGD
Official Full Name: activin A receptor type 2Aprovided by RGD
Primary source: RGD:70911
See related: EnsemblRapid:ENSRNOG00000065897 AllianceGenome:RGD:70911
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Acvr2; rActR-II
Summary: Enables activin binding activity and inhibin binding activity. Involved in several processes, including SMAD protein signal transduction; cellular response to oxygen-glucose deprivation; and positive regulation of follicle-stimulating hormone secretion. Predicted to be located in cell surface and cytoplasm. Predicted to be part of activin receptor complex and inhibin-betaglycan-ActRII complex. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in Lynch syndrome and colon cancer. Orthologous to human ACVR2A (activin A receptor type 2A). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Lung (RPKM 192.7), Brain (RPKM 161.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q12

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (53614143..53701933)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (33204961..33292673)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (32947901..33034598)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In a rat model of HF, we demonstrated a concerted induction of the gene expression of activin betaA and activin receptors IA, IB, IIA, and IIB after myocardial infarction.
Title: Elevated levels of activin A in heart failure: potential role in myocardial remodeling.

Submit: New GeneRIF Correction

General gene information

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Markers

D3Rat82 (e-PCR), detects polymorphism
- UniSTS:118794

ksks388 (e-PCR)
- UniSTS:514439

MARC_17905-17906:1025019334:1 (e-PCR)
- UniSTS:268437

Acvr2a (e-PCR), detects polymorphism
- UniSTS:530848

MARC_31635-31636:1045776384:1 (e-PCR)
- UniSTS:269216

Acvr2 (e-PCR), detects polymorphism
- UniSTS:141022

Acvr2b (e-PCR), detects polymorphism
- UniSTS:141023

Acvr2 (e-PCR), detects polymorphism
- UniSTS:233952

Acvr2a (e-PCR), detects polymorphism
- UniSTS:496631

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables BMP receptor activity	IEA Inferred from Electronic Annotation more info
enables BMP receptor activity	ISO Inferred from Sequence Orthology more info
enables BMP receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables PDZ domain binding	IEA Inferred from Electronic Annotation more info
enables PDZ domain binding	ISO Inferred from Sequence Orthology more info
enables activin binding	IDA Inferred from Direct Assay more info	PubMed
enables activin binding	IEA Inferred from Electronic Annotation more info
contributes_to activin binding	ISO Inferred from Sequence Orthology more info
enables activin binding	ISO Inferred from Sequence Orthology more info
enables activin binding	TAS Traceable Author Statement more info	PubMed
enables activin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to activin receptor activity	ISO Inferred from Sequence Orthology more info
enables activin receptor activity	ISO Inferred from Sequence Orthology more info
enables activin receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables activin receptor activity, type I	IEA Inferred from Electronic Annotation more info
enables activin receptor activity, type I	ISO Inferred from Sequence Orthology more info
enables activin receptor activity, type II	IEA Inferred from Electronic Annotation more info
enables activin receptor activity, type II	ISO Inferred from Sequence Orthology more info
enables coreceptor activity	IEA Inferred from Electronic Annotation more info
enables coreceptor activity	ISO Inferred from Sequence Orthology more info
enables growth factor binding	IEA Inferred from Electronic Annotation more info
enables growth factor binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables inhibin binding	IDA Inferred from Direct Assay more info	PubMed
enables inhibin binding	IEA Inferred from Electronic Annotation more info
enables inhibin binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables transforming growth factor beta receptor activity, type I	IEA Inferred from Electronic Annotation more info
enables transforming growth factor beta receptor activity, type II	IEA Inferred from Electronic Annotation more info
enables transforming growth factor beta receptor activity, type III	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein serine/threonine kinase activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in BMP signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within BMP signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in BMP signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in BMP signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in SMAD protein signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in Sertoli cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within Sertoli cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in activin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in activin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in activin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adrenal gland development	IEP Inferred from Expression Pattern more info	PubMed
involved_in anterior/posterior pattern specification	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within anterior/posterior pattern specification	ISO Inferred from Sequence Orthology more info
involved_in autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell surface receptor protein serine/threonine kinase signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cellular response to BMP stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to growth factor stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to oxygen-glucose deprivation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of left/right symmetry	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within determination of left/right symmetry	ISO Inferred from Sequence Orthology more info
involved_in embryonic skeletal system development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within embryonic skeletal system development	ISO Inferred from Sequence Orthology more info
involved_in gastrulation with mouth forming second	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within gastrulation with mouth forming second	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within male gonad development	ISO Inferred from Sequence Orthology more info
involved_in mesoderm development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mesoderm development	ISO Inferred from Sequence Orthology more info
involved_in odontogenesis of dentin-containing tooth	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within odontogenesis of dentin-containing tooth	ISO Inferred from Sequence Orthology more info
involved_in osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in pattern specification process	IBA Inferred from Biological aspect of Ancestor more info
involved_in penile erection	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within penile erection	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of SMAD protein signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of SMAD protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of activin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of activin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of bone mineralization	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of bone mineralization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of erythrocyte differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of erythrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of follicle-stimulating hormone secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of osteoblast differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of osteoblast differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	TAS Traceable Author Statement more info	PubMed
involved_in regulation of nitric oxide biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of nitric oxide biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of signal transduction	ISO Inferred from Sequence Orthology more info
involved_in sperm ejaculation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sperm ejaculation	ISO Inferred from Sequence Orthology more info
involved_in spermatogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within spermatogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of activin receptor complex	IBA Inferred from Biological aspect of Ancestor more info
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
part_of inhibin-betaglycan-ActRII complex	IEA Inferred from Electronic Annotation more info
part_of inhibin-betaglycan-ActRII complex	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
part_of receptor complex	IEA Inferred from Electronic Annotation more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: activin receptor type-2A

Names: ACTR-IIA; activin A receptor, type IIA; activin receptor IIA; activin receptor type IIA; type II activin receptor

NP_113759.2

EC 2.7.11.30

XP_063139269.1

EC 2.7.11.30

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031571.3 → NP_113759.2 activin receptor type-2A precursor

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

P38444

UniProtKB/TrEMBL

A6JEZ1

Related

ENSRNOP00000083010.2, ENSRNOT00000113342.2

Conserved Domains (2) summary

cd14141
Location:196 → 485

STKc_ACVR2a; Catalytic domain of the Serine/Threonine Kinase, Activin Type IIA Receptor

pfam01064
Location:59 → 114

Activin_recp; Activin types I and II receptor domain