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Rinl Ras and Rab interactor-like [ Rattus norvegicus (Norway rat) ]

Gene ID: 292760, updated on 4-Jan-2025

Summary

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Official Symbol
Rinlprovided by RGD
Official Full Name
Ras and Rab interactor-likeprovided by RGD
Primary source
RGD:1310133
See related
EnsemblRapid:ENSRNOG00000025354 AllianceGenome:RGD:1310133
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1310133
Summary
Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Predicted to act upstream of or within endocytosis. Predicted to be located in actin cytoskeleton and ruffle. Predicted to be active in cytosol and endocytic vesicle. Orthologous to human RINL (Ras and Rab interactor like). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Thymus (RPKM 42.1), Spleen (RPKM 20.4) and 6 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rinl in Genome Data Viewer
Location:
1q21
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (93204543..93215851)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (84077011..84088590)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (86971997..86983306)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene MARCKS-related protein-like Neighboring gene uncharacterized LOC134483092 Neighboring gene NFKB inhibitor beta Neighboring gene sirtuin 2 Neighboring gene heterogeneous nuclear ribonucleoprotein L Neighboring gene enoyl-CoA hydratase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Rin-like, a novel regulator of endocytosis, acts as guanine nucleotide exchange factor for Rab5a and Rab22. Woller B, et al. Biochim Biophys Acta, 2011 Jun. PMID 21419809, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
  
enables small GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within endocytosis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endocytic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in ruffle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ras and Rab interactor-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106241.2 → NP_001099711.1  ras and Rab interactor-like protein

    See identical proteins and their annotated locations for NP_001099711.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A6J9L1, D3ZP73
    Related
    ENSRNOP00000034246.3, ENSRNOT00000036907.6
    Conserved Domains (2) summary
    pfam02204
    Location:417 → 519
    VPS9; Vacuolar sorting protein 9 (VPS9) domain
    cl15255
    Location:43 → 136
    SH2; Src homology 2 (SH2) domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    93204543..93215851
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006228653.5 → XP_006228715.1  ras and Rab interactor-like protein isoform X1

    Conserved Domains (2) summary
    pfam02204
    Location:521 → 623
    VPS9; Vacuolar sorting protein 9 (VPS9) domain
    cl15255
    Location:147 → 240
    SH2; Src homology 2 (SH2) domain

  2. XM_006228655.5 → XP_006228717.1  ras and Rab interactor-like protein isoform X2

    Conserved Domains (2) summary
    cl15255
    Location:147 → 240
    SH2; Src homology 2 (SH2) domain
    cl19569
    Location:521 → 579
    VPS9; Vacuolar sorting protein 9 (VPS9) domain

  3. XM_006228656.5 → XP_006228718.1  ras and Rab interactor-like protein isoform X5

    Conserved Domains (2) summary
    cl15255
    Location:147 → 240
    SH2; Src homology 2 (SH2) domain
    cl19569
    Location:521 → 562
    VPS9; Vacuolar sorting protein 9 (VPS9) domain

  4. XM_006228657.4 → XP_006228719.1  ras and Rab interactor-like protein isoform X6

    Related
    ENSRNOP00000106412.1, ENSRNOT00000139379.1
    Conserved Domains (2) summary
    pfam02204
    Location:411 → 513
    VPS9; Vacuolar sorting protein 9 (VPS9) domain
    cl15255
    Location:37 → 130
    SH2; Src homology 2 (SH2) domain

  5. XM_063283399.1 → XP_063139469.1  ras and Rab interactor-like protein isoform X3

    UniProtKB/TrEMBL
    A0A0G2K4Y9
    Related
    ENSRNOP00000073226.2, ENSRNOT00000078156.3

  6. XM_039104237.2 → XP_038960165.1  ras and Rab interactor-like protein isoform X4

    UniProtKB/TrEMBL
    A6J9L1, D3ZP73
    Conserved Domains (2) summary
    pfam02204
    Location:417 → 519
    VPS9; Vacuolar sorting protein 9 (VPS9) domain
    cl15255
    Location:43 → 136
    SH2; Src homology 2 (SH2) domain
Nucleotide Protein Strain
Heading Accession and Version

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