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Spint2 serine peptidase inhibitor, Kunitz type, 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 292770, updated on 4-Jan-2025

Summary

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Official Symbol
Spint2provided by RGD
Official Full Name
serine peptidase inhibitor, Kunitz type, 2provided by RGD
Primary source
RGD:735123
See related
EnsemblRapid:ENSRNOG00000020636 AllianceGenome:RGD:735123
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Pb; HAI-2
Summary
Predicted to enable serine-type endopeptidase inhibitor activity. Involved in cellular response to BMP stimulus and negative regulation of neural precursor cell proliferation. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in congenital secretory sodium diarrhea 3. Orthologous to human SPINT2 (serine peptidase inhibitor, Kunitz type 2). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Kidney (RPKM 1506.7), Lung (RPKM 690.5) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Spint2 in Genome Data Viewer
Location:
1q21
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (93685637..93708091, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (84558159..84580616, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (87199373..87221826, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene MARCKS-related protein-like Neighboring gene similar to human chromosome 19 open reading frame 33 Neighboring gene potassium two pore domain channel subfamily K member 6 Neighboring gene Yip1 interacting factor homolog B, membrane trafficking protein Neighboring gene protein phosphatase 1, regulatory (inhibitor) subunit 14A Neighboring gene double PHD fingers 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Mutations in SPINT2 cause a syndromic form of congenital sodium diarrhea. Heinz-Erian P, et al. Am J Hum Genet, 2009 Feb. PMID 19185281, Free PMC Article
  2. Identification of hepatocyte growth factor activator inhibitor type 2 (HAI-2)-related small peptide (H2RSP): its nuclear localization and generation of chimeric mRNA transcribed from both HAI-2 and H2RSP genes. Itoh H, et al. Biochem Biophys Res Commun, 2001 Oct 26. PMID 11606055
  3. Hepatocyte growth factor activator inhibitor-1 is induced by bone morphogenetic proteins and regulates proliferation and cell fate of neural progenitor cells. Koivuniemi R, et al. PLoS One, 2013. PMID 23409135, Free PMC Article
  4. Persistent elevation of hepatocyte growth factor activator inhibitors in cholangiopathies affects liver fibrosis and differentiation. Huang HP, et al. Hepatology, 2012 Jan. PMID 21898507
  5. Regulation of cell surface protease matriptase by HAI2 is essential for placental development, neural tube closure and embryonic survival in mice. Szabo R, et al. Development, 2009 Aug. PMID 19592578, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC72638

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables serine-type endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type endopeptidase inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within basement membrane organization ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to BMP stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within epithelial cell morphogenesis involved in placental branching ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within establishment or maintenance of cell polarity ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of cell motility ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of neural precursor cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within neural tube closure ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
kunitz-type protease inhibitor 2
Names
hepatocyte growth factor activator inhibitor type 2
placental bikunin
serine protease inhibitor, Kunitz type 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001082549.1 → NP_001076018.1  kunitz-type protease inhibitor 2 isoform a precursor

    See identical proteins and their annotated locations for NP_001076018.1

    Status: VALIDATED

    Source sequence(s)
    BC061768, DN934634
    UniProtKB/TrEMBL
    A6J9Q4, F6QKA3, G3V8S0
    Related
    ENSRNOP00000043981.3, ENSRNOT00000046611.6
    Conserved Domains (1) summary
    pfam00014
    Location:38 → 88
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain

  2. NM_199087.1 → NP_954518.1  kunitz-type protease inhibitor 2 isoform b precursor

    See identical proteins and their annotated locations for NP_954518.1

    Status: VALIDATED

    Source sequence(s)
    BC061768
    UniProtKB/TrEMBL
    Q6P796
    Conserved Domains (1) summary
    pfam00014
    Location:73 → 124
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    93685637..93708091 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063283557.1 → XP_063139627.1  kunitz-type protease inhibitor 2 isoform X1

Nucleotide Protein Strain
Heading Accession and Version

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