Ffar2 free fatty acid receptor 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ffar2provided by RGD
Official Full Name: free fatty acid receptor 2provided by RGD
Primary source: RGD:1359614
See related: EnsemblRapid:ENSRNOG00000021021 AllianceGenome:RGD:1359614
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Gpr43
Summary: Enables G protein-coupled receptor activity. Involved in G protein-coupled receptor signaling pathway and cellular response to fatty acid. Located in cell projection. Orthologous to human FFAR2 (free fatty acid receptor 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 32.4), Lung (RPKM 11.9) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q21

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (95199277..95202599, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (86071855..86075049, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (89268197..89271942, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Short-chain fatty acid receptors involved in epithelial acetylcholine release in rat caecum.
Title: Short-chain fatty acid receptors involved in epithelial acetylcholine release in rat caecum.
GPR43 deficiency protects against podocyte insulin resistance in diabetic nephropathy through the restoration of AMPKalpha activity.
Title: GPR43 deficiency protects against podocyte insulin resistance in diabetic nephropathy through the restoration of AMPKα activity.
Depends on the afferent colonic vagus nerve signaling and GPR41/43 receptors.
Title: Butyric acid, a gut bacteria metabolite, lowers arterial blood pressure via colon-vagus nerve signaling and GPR41/43 receptors.
These present data have shown for the first time that total mRNA isolation and protein expression from both adipose tissues (abdominal and subcutaneous) of rat in obesity condition yield significative statistical difference among the control versus obese groups, showing that the diet high in carbohydrates modifies the total presence of mRNA and protein level expression of the receptors GPR41, 43 and 120
Title: Characterization of free fatty acid receptors expression in an obesity rat model with high sucrose diet.
By acting through GPR41 and 43, butyrate enhanced intracellular free cytosolic Ca2+. Gene-specific silencing of these receptors led to a partial inhibition of the butyrate-induced intracellular Ca2+ rise resulting in a decrease of hGH secretion.
Title: Butyrate increases intracellular calcium levels and enhances growth hormone release from rat anterior pituitary cells via the G-protein-coupled receptors GPR41 and 43.
Extracellular ionic locks determine variation in constitutive activity and ligand potency between species orthologs of the free fatty acid receptors FFA2 and FFA3
Title: Extracellular ionic locks determine variation in constitutive activity and ligand potency between species orthologs of the free fatty acid receptors FFA2 and FFA3.
up-regulation of GPR43 and GPR120 in response to a high fat diet, is tissue specific
Title: Diet-induced obesity up-regulates the abundance of GPR43 and GPR120 in a tissue specific manner.
The results suggest that the PYY-containing enteroendocrine cells and 5-HT-containing mucosal mast cells sense SCFAs via the GPR43 receptor.
Title: Short-chain fatty acid receptor, GPR43, is expressed by enteroendocrine cells and mucosal mast cells in rat intestine.

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General gene information

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Markers

Ffar2 (e-PCR), detects polymorphism
- UniSTS:534575

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables G protein-coupled receptor activity	ISO Inferred from Sequence Orthology more info
enables lipid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
involved_in cell surface pattern recognition receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cell surface pattern recognition receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to fatty acid	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to fatty acid	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to fatty acid	ISO Inferred from Sequence Orthology more info
involved_in fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in fat cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in glucose homeostasis	ISO Inferred from Sequence Orthology more info
involved_in glucose homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in leukocyte chemotaxis involved in inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in leukocyte chemotaxis involved in inflammatory response	ISS Inferred from Sequence or Structural Similarity more info
involved_in ligand-gated ion channel signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in lipid storage	ISO Inferred from Sequence Orthology more info
involved_in lipid storage	ISS Inferred from Sequence or Structural Similarity more info
involved_in mucosal immune response	ISO Inferred from Sequence Orthology more info
involved_in mucosal immune response	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of insulin secretion	ISO Inferred from Sequence Orthology more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of acute inflammatory response to non-antigenic stimulus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of acute inflammatory response to non-antigenic stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of chemokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of chemokine production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cytokine production involved in immune response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytokine production involved in immune response	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of insulin secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-8 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-8 production	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of acute inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in regulation of acute inflammatory response	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of peptide hormone secretion	ISO Inferred from Sequence Orthology more info
involved_in regulation of peptide hormone secretion	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cell projection	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: free fatty acid receptor 2

Names: G-protein coupled receptor 43

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001005877.3 → NP_001005877.1 free fatty acid receptor 2

See identical proteins and their annotated locations for NP_001005877.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

Q76EI6

UniProtKB/TrEMBL

A6JA27

Related

ENSRNOP00000092741.1, ENSRNOT00000110584.2

Conserved Domains (1) summary

cd15170
Location:9 → 286

7tmA_FFAR2_FFAR3; free fatty acid receptors 2, 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

95199277..95202599 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008759135.3 → XP_008757357.1 free fatty acid receptor 2 isoform X1

See identical proteins and their annotated locations for XP_008757357.1

UniProtKB/Swiss-Prot

Q76EI6

UniProtKB/TrEMBL

A6JA27

Related

ENSRNOP00000028532.1, ENSRNOT00000028532.4

Conserved Domains (1) summary

cd15170
Location:9 → 286

7tmA_FFAR2_FFAR3; free fatty acid receptors 2, 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_008759134.4 → XP_008757356.1 free fatty acid receptor 2 isoform X1

See identical proteins and their annotated locations for XP_008757356.1

UniProtKB/Swiss-Prot

Q76EI6

UniProtKB/TrEMBL

A6JA27

Conserved Domains (1) summary

cd15170
Location:9 → 286

7tmA_FFAR2_FFAR3; free fatty acid receptors 2, 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_008759133.4 → XP_008757355.1 free fatty acid receptor 2 isoform X1

See identical proteins and their annotated locations for XP_008757355.1

UniProtKB/Swiss-Prot

Q76EI6

UniProtKB/TrEMBL

A6JA27

Conserved Domains (1) summary

cd15170
Location:9 → 286

7tmA_FFAR2_FFAR3; free fatty acid receptors 2, 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_039104526.2 → XP_038960454.1 free fatty acid receptor 2 isoform X1

UniProtKB/Swiss-Prot

Q76EI6

UniProtKB/TrEMBL

A6JA27

Conserved Domains (1) summary

cd15170
Location:9 → 286

7tmA_FFAR2_FFAR3; free fatty acid receptors 2, 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors