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Siglec5 sialic acid binding Ig-like lectin 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 292843, updated on 4-Jan-2025

Summary

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Official Symbol
Siglec5provided by RGD
Official Full Name
sialic acid binding Ig-like lectin 5provided by RGD
Primary source
RGD:1305432
See related
EnsemblRapid:ENSRNOG00000021474 AllianceGenome:RGD:1305432
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable sialic acid binding activity. Predicted to be involved in cell adhesion. Predicted to be located in cytosol. Predicted to be active in plasma membrane. Orthologous to several human genes including SIGLEC14 (sialic acid binding Ig like lectin 14) and SIGLEC5 (sialic acid binding Ig like lectin 5). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Spleen (RPKM 103.1), Lung (RPKM 37.9) and 8 other tissues See more
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Genomic context

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See Siglec5 in Genome Data Viewer
Location:
1q22
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (102904705..102913281)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (93768190..93776696)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (98562351..98570992, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene interferon stimulated exonuclease gene 20 like 1 Neighboring gene zinc finger protein 715 Neighboring gene sialic acid binding Ig-like lectin 10 Neighboring gene uncharacterized LOC102550061 Neighboring gene similar to human chromosome 19 open reading frame 84

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Distinct endocytic mechanisms of CD22 (Siglec-2) and Siglec-F reflect roles in cell signaling and innate immunity. Tateno H, et al. Mol Cell Biol, 2007 Aug. PMID 17562860, Free PMC Article
  2. The murine inhibitory receptor mSiglec-E is expressed broadly on cells of the innate immune system whereas mSiglec-F is restricted to eosinophils. Zhang JQ, et al. Eur J Immunol, 2004 Apr. PMID 15048729
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables sialic acid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
sialic acid-binding Ig-like lectin 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106249.2 → NP_001099719.2  sialic acid-binding Ig-like lectin 5 precursor

    See identical proteins and their annotated locations for NP_001099719.2

    Status: PROVISIONAL

    Source sequence(s)
    CH473979
    UniProtKB/TrEMBL
    A0A8I6AAM7, A6JAH1
    Related
    ENSRNOP00000088341.1, ENSRNOT00000106528.2
    Conserved Domains (3) summary
    smart00408
    Location:257 → 315
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:252 → 325
    IG_like; Immunoglobulin like
    cl11960
    Location:20 → 133
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    102904705..102913281
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006228946.5 → XP_006229008.1  sialic acid-binding Ig-like lectin 5 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AAM7, D3Z9T4
    Related
    ENSRNOP00000034882.4, ENSRNOT00000033648.6
    Conserved Domains (3) summary
    smart00408
    Location:257 → 315
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:252 → 325
    IG_like; Immunoglobulin like
    cl11960
    Location:20 → 133
    Ig; Immunoglobulin domain

  2. XM_039104606.2 → XP_038960534.1  sialic acid-binding Ig-like lectin 5 isoform X2

    Conserved Domains (3) summary
    smart00410
    Location:252 → 325
    IG_like; Immunoglobulin like
    cd00096
    Location:20 → 24
    Ig; Ig strand A [structural motif]
    cl11960
    Location:20 → 133
    Ig; Immunoglobulin domain
Nucleotide Protein Strain
Heading Accession and Version

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