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Siglec10 sialic acid binding Ig-like lectin 10 [ Rattus norvegicus (Norway rat) ]

Gene ID: 292844, updated on 27-Nov-2024

Summary

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Official Symbol
Siglec10provided by RGD
Official Full Name
sialic acid binding Ig-like lectin 10provided by RGD
Primary source
RGD:1307441
See related
EnsemblRapid:ENSRNOG00000037339 AllianceGenome:RGD:1307441
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Siglecg
Summary
Predicted to enable SH2 domain binding activity; phosphatase binding activity; and sialic acid binding activity. Predicted to be involved in cell adhesion and negative regulation of inflammatory response to wounding. Predicted to be active in plasma membrane. Orthologous to several human genes including SIGLEC10 (sialic acid binding Ig like lectin 10). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 151.5), Lung (RPKM 46.2) and 1 other tissue See more
Orthologs
human all
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Genomic context

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See Siglec10 in Genome Data Viewer
Location:
1q22
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (102953894..102962964)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (93817301..93826376)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (98512663..98521736, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein 715 Neighboring gene sialic acid binding Ig-like lectin 5 Neighboring gene uncharacterized LOC102550061 Neighboring gene similar to human chromosome 19 open reading frame 84 Neighboring gene lens intrinsic membrane protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification, characterization and leucocyte expression of Siglec-10, a novel human sialic acid-binding receptor. Munday J, et al. Biochem J, 2001 Apr 15. PMID 11284738, Free PMC Article
  2. CD22 x Siglec-G double-deficient mice have massively increased B1 cell numbers and develop systemic autoimmunity. Jellusova J, et al. J Immunol, 2010 Apr 1. PMID 20200274
  3. Cloning of two new splice variants of Siglec-10 and mapping of the interaction between Siglec-10 and SHP-1. Kitzig F, et al. Biochem Biophys Res Commun, 2002 Aug 16. PMID 12163025
  4. CD24 and Siglec-10 selectively repress tissue damage-induced immune responses. Chen GY, et al. Science, 2009 Mar 27. PMID 19264983, Free PMC Article
  5. Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7. Nagamachi A, et al. Cancer Cell, 2013 Sep 9. PMID 24029230

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables SH2 domain binding ISO
Inferred from Sequence Orthology
more info
  
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatase binding ISO
Inferred from Sequence Orthology
more info
  
enables sialic acid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in hematopoietic progenitor cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of calcium-mediated signaling IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of immunoglobulin production IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of inflammatory response to wounding ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of B cell proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of immune response IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
sialic acid-binding Ig-like lectin 10
Names
sialic acid binding Ig-like lectin G

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001401363.1 → NP_001388292.1  sialic acid-binding Ig-like lectin 10 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A0G2JVW0
    Related
    ENSRNOP00000069639.1, ENSRNOT00000081922.3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    102953894..102962964
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063283803.1 → XP_063139873.1  sialic acid-binding Ig-like lectin 10 isoform X1

  2. XM_039104625.2 → XP_038960553.1  sialic acid-binding Ig-like lectin 10 isoform X2

    UniProtKB/TrEMBL
    A6JAH3, D3ZF71
    Conserved Domains (2) summary
    cd00096
    Location:44 → 49
    Ig; Ig strand A [structural motif]
    cl11960
    Location:44 → 123
    Ig; Immunoglobulin domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001106250.1: Suppressed sequence

    Description
    NM_001106250.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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