Klk1c3 kallikrein 1-related peptidase C3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Klk1c3provided by RGD
Full Name: kallikrein 1-related peptidase C3provided by RGD
Primary source: RGD:735032
See related: EnsemblRapid:ENSRNOG00000033414 AllianceGenome:RGD:735032
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: KLK3; Klk-3; rGK-3; RSGK-50; RSKG-50; Klk1c10l2
Summary: Predicted to enable serine-type endopeptidase activity. Predicted to be involved in regulation of systemic arterial blood pressure and zymogen activation. Predicted to be active in extracellular space and secretory granule. Human ortholog(s) of this gene implicated in cardiomyopathy; chronic kidney disease; end stage renal disease; hypertension; and myocardial infarction. Orthologous to several human genes including KLK1 (kallikrein 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Kidney (RPKM 223.2) and Muscle (RPKM 13.8) See more
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Genomic context

Location:: 1q22

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (103808150..103811931)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (94671636..94675417)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (100141205..100163945)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tissue kallikrein protects against acute-phase myocardial infarction by promoting neovascularization, restoring regional blood flow and improving cardiac function through the kinin B2 receptor-Akt-GSK-3beta and VEGF signalling pathways.
Title: Tissue kallikrein promotes neovascularization and improves cardiac function by the Akt-glycogen synthase kinase-3beta pathway.
Tissue kallikrein improves cardiac function, prevents inflammation and limits left ventricular remodeling after myocardial ischemia/reperfusion.
Title: Nitric oxide mediates cardiac protection of tissue kallikrein by reducing inflammation and ventricular remodeling after myocardial ischemia/reperfusion.
KLK3 rat gene was expressed at high levels in the submandibular glands of transgenic mice.
Title: The transcriptional regulatory strategy of the rat tissue kallikrein gene family.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in regulation of systemic arterial blood pressure	IBA Inferred from Biological aspect of Ancestor more info
involved_in zymogen activation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
is_active_in secretory granule	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: glandular kallikrein-3, submandibular

Names: S1 kallikrein; glandular kallikrein-3, submandibular-like; kallikrein 1-related peptidase c10-like 2; kallikrein 3; submaxillary gland S1 kallikrein; tissue kallikrein

NP_001258244.1

EC 3.4.21.35

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001271315.1 → NP_001258244.1 glandular kallikrein-3, submandibular precursor

See identical proteins and their annotated locations for NP_001258244.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A0A0A0MXZ4, Q63275

Related

ENSRNOP00000110304.1, ENSRNOT00000121588.1

Conserved Domains (2) summary

smart00020
Location:24 → 247

Tryp_SPc; Trypsin-like serine protease

cd00190
Location:25 → 250

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...