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Bclaf1 BCL2-associated transcription factor 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 293017, updated on 27-Nov-2024

Summary

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Official Symbol
Bclaf1provided by RGD
Official Full Name
BCL2-associated transcription factor 1provided by RGD
Primary source
RGD:1309704
See related
EnsemblRapid:ENSRNOG00000058050 AllianceGenome:RGD:1309704
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Aa2-041
Summary
Predicted to enable DNA binding activity. Predicted to be involved in DNA damage response; positive regulation of DNA-templated transcription initiation; and positive regulation of intrinsic apoptotic signaling pathway. Predicted to act upstream of or within cellular response to leukemia inhibitory factor; negative regulation of DNA-templated transcription; and positive regulation of apoptotic process. Predicted to be located in nuclear speck. Orthologous to human BCLAF1 (BCL2 associated transcription factor 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 523.8), Adrenal (RPKM 431.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Bclaf1 in Genome Data Viewer
Location:
1p12
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (16904572..16937106)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (15088436..15117666)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (15799753..15828838)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene microtubule-associated protein 7 Neighboring gene uncharacterized LOC120098801 Neighboring gene U6 spliceosomal RNA Neighboring gene mitochondrial fission regulator 2 Neighboring gene phosphodiesterase 7B Neighboring gene uncharacterized LOC134484964

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Protein kinase C delta induces transcription of the TP53 tumor suppressor gene by controlling death-promoting factor Btf in the apoptotic response to DNA damage. Liu H, et al. Mol Cell Biol, 2007 Dec. PMID 17938203, Free PMC Article
  2. Btf, a novel death-promoting transcriptional repressor that interacts with Bcl-2-related proteins. Kasof GM, et al. Mol Cell Biol, 1999 Jun. PMID 10330179, Free PMC Article
  3. Identification of Wilms' tumor 1-associating protein complex and its role in alternative splicing and the cell cycle. Horiuchi K, et al. J Biol Chem, 2013 Nov 15. PMID 24100041, Free PMC Article
  4. Involvement of Bcl-2-associated transcription factor 1 in the differentiation of early-born retinal cells. Orieux G, et al. J Neurosci, 2014 Jan 22. PMID 24453340, Free PMC Article
  5. miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells. Tarantino C, et al. FASEB J, 2010 Sep. PMID 20439489

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
  
involved_in aerobic respiration IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cellular response to leukemia inhibitory factor ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial fission IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription initiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
bcl-2-associated transcription factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001047852.2 → NP_001041317.2  bcl-2-associated transcription factor 1

    See identical proteins and their annotated locations for NP_001041317.2

    Status: PROVISIONAL

    Source sequence(s)
    BC161968
    UniProtKB/TrEMBL
    A0A8I5Y6Z0, B1WC16
    Related
    ENSRNOP00000072352.3, ENSRNOT00000089966.3
    Conserved Domains (2) summary
    pfam15440
    Location:157 → 746
    THRAP3_BCLAF1; THRAP3/BCLAF1 family
    cl09653
    Location:828 → 893
    Btz; CASC3/Barentsz eIF4AIII binding

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    16904572..16937106
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063284458.1 → XP_063140528.1  bcl-2-associated transcription factor 1 isoform X2

    UniProtKB/TrEMBL
    B1WC16

  2. XM_063284466.1 → XP_063140536.1  bcl-2-associated transcription factor 1 isoform X4

  3. XM_063284478.1 → XP_063140548.1  bcl-2-associated transcription factor 1 isoform X6

    Related
    ENSRNOP00000097938.2, ENSRNOT00000094509.2

  4. XM_063284485.1 → XP_063140555.1  bcl-2-associated transcription factor 1 isoform X7

  5. XM_063284439.1 → XP_063140509.1  bcl-2-associated transcription factor 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AX06

  6. XM_006227654.5 → XP_006227716.1  bcl-2-associated transcription factor 1 isoform X3

    UniProtKB/TrEMBL
    A0A8I5Y6Z0
    Conserved Domains (2) summary
    pfam15440
    Location:155 → 741
    THRAP3_BCLAF1; THRAP3/BCLAF1 family
    cl09653
    Location:826 → 891
    Btz; CASC3/Barentsz eIF4AIII binding

  7. XM_006227652.5 → XP_006227714.1  bcl-2-associated transcription factor 1 isoform X2

    See identical proteins and their annotated locations for XP_006227714.1

    UniProtKB/TrEMBL
    A0A8I5Y6Z0, B1WC16
    Conserved Domains (2) summary
    pfam15440
    Location:157 → 746
    THRAP3_BCLAF1; THRAP3/BCLAF1 family
    cl09653
    Location:828 → 893
    Btz; CASC3/Barentsz eIF4AIII binding

  8. XM_006227653.4 → XP_006227715.1  bcl-2-associated transcription factor 1 isoform X2

    See identical proteins and their annotated locations for XP_006227715.1

    UniProtKB/TrEMBL
    A0A8I5Y6Z0, B1WC16
    Related
    ENSRNOP00000076713.2, ENSRNOT00000100188.2
    Conserved Domains (2) summary
    pfam15440
    Location:157 → 746
    THRAP3_BCLAF1; THRAP3/BCLAF1 family
    cl09653
    Location:828 → 893
    Btz; CASC3/Barentsz eIF4AIII binding

  9. XM_063284449.1 → XP_063140519.1  bcl-2-associated transcription factor 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AX06
    Related
    ENSRNOP00000071825.3, ENSRNOT00000088025.3

  10. XM_039105467.2 → XP_038961395.1  bcl-2-associated transcription factor 1 isoform X3

    UniProtKB/TrEMBL
    A0A8I5Y6Z0
    Related
    ENSRNOP00000068911.3, ENSRNOT00000078589.3
    Conserved Domains (2) summary
    pfam15440
    Location:155 → 741
    THRAP3_BCLAF1; THRAP3/BCLAF1 family
    cl09653
    Location:826 → 891
    Btz; CASC3/Barentsz eIF4AIII binding

  11. XM_063284473.1 → XP_063140543.1  bcl-2-associated transcription factor 1 isoform X5

RNA

  1. XR_010064690.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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Chemical Information
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