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Btbd1 BTB domain containing 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 293060, updated on 27-Nov-2024

Summary

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Official Symbol
Btbd1provided by RGD
Official Full Name
BTB domain containing 1provided by RGD
Primary source
RGD:1310962
See related
EnsemblRapid:ENSRNOG00000019529 AllianceGenome:RGD:1310962
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable cullin family protein binding activity and identical protein binding activity. Predicted to be involved in neurogenesis. Predicted to be located in cytoplasmic ribonucleoprotein granule and nucleoplasm. Predicted to be part of protein-containing complex. Predicted to be active in P-body and cytosol. Orthologous to human BTBD1 (BTB domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 868.9), Muscle (RPKM 814.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Btbd1 in Genome Data Viewer
Location:
1q31
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (145143806..145183653, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (135734549..135773067, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (143609729..143647124, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene homer scaffold protein 2 Neighboring gene RNA, U6 small nuclear 946 Neighboring gene similar to human chromosome 15 open reading frame 40 Neighboring gene RNA guanine-7 methyltransferase activating subunit Neighboring gene transmembrane 6 superfamily member 1 Neighboring gene HDGF like 3 Neighboring gene uncharacterized LOC102556513

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. Xu L, et al. Exp Cell Res, 2003 Aug 1. PMID 12878161
  2. Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases. Furukawa M, et al. Nat Cell Biol, 2003 Nov. PMID 14528312
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cullin family protein binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in neurogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in P-body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in P-body ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic ribonucleoprotein granule ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
BTB/POZ domain-containing protein 1
Names
BTB (POZ) domain containing 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001011932.1 → NP_001011932.1  BTB/POZ domain-containing protein 1

    See identical proteins and their annotated locations for NP_001011932.1

    Status: PROVISIONAL

    Source sequence(s)
    BC085850
    UniProtKB/TrEMBL
    Q5RKI2
    Related
    ENSRNOP00000026595.4, ENSRNOT00000026595.7
    Conserved Domains (4) summary
    smart00225
    Location:94 → 181
    BTB; Broad-Complex, Tramtrack and Bric a brac
    smart00875
    Location:193 → 292
    BACK; BTB And C-terminal Kelch
    pfam00651
    Location:68 → 177
    BTB; BTB/POZ domain
    pfam08005
    Location:340 → 486
    PHR; PHR domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    145143806..145183653 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_010064711.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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