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Tmc3 transmembrane channel-like 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 293065, updated on 9-Dec-2024

Summary

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Official Symbol
Tmc3provided by RGD
Official Full Name
transmembrane channel-like 3provided by RGD
Primary source
RGD:1308063
See related
EnsemblRapid:ENSRNOG00000025088 AllianceGenome:RGD:1308063
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable mechanosensitive monoatomic ion channel activity. Predicted to be involved in monoatomic ion transmembrane transport. Predicted to be located in plasma membrane. Orthologous to human TMC3 (transmembrane channel like 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Kidney (RPKM 43.6) and Liver (RPKM 39.8) See more
Orthologs
human mouse all
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Genomic context

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See Tmc3 in Genome Data Viewer
Location:
1q31
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (146961518..147009742)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (137552347..137597477)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (145715808..145763690)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102552825 Neighboring gene U2 spliceosomal RNA Neighboring gene StAR-related lipid transfer domain containing 5 Neighboring gene small nuclear ribonucleoprotein polypeptide C, pseudogene 10 Neighboring gene interleukin 16

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables mechanosensitive monoatomic ion channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transmembrane channel-like protein 3
Names
StAR-related lipid transfer (START) domain containing 5
transmembrane channel-like gene family 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001170432.1 → NP_001163903.1  transmembrane channel-like protein 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    D3ZHV6
    Related
    ENSRNOP00000037802.5, ENSRNOT00000037996.7
    Conserved Domains (1) summary
    pfam07810
    Location:505 → 611
    TMC; TMC domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    146961518..147009742
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008759610.4 → XP_008757832.1  transmembrane channel-like protein 3 isoform X1

    Conserved Domains (1) summary
    pfam07810
    Location:500 → 615
    TMC; TMC domain
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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