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Zfand6 zinc finger AN1-type containing 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 293067, updated on 27-Nov-2024

Summary

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Official Symbol
Zfand6provided by RGD
Official Full Name
zinc finger AN1-type containing 6provided by RGD
Primary source
RGD:1359317
See related
EnsemblRapid:ENSRNOG00000013506 AllianceGenome:RGD:1359317
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Za20d3; zgc:101121
Summary
Predicted to enable polyubiquitin modification-dependent protein binding activity. Predicted to be involved in several processes, including cellular response to tumor necrosis factor; protein targeting to peroxisome; and regulation of canonical NF-kappaB signal transduction. Predicted to act upstream of or within signal transduction. Predicted to be located in cytoplasm. Orthologous to human ZFAND6 (zinc finger AN1-type containing 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 182.5), Spleen (RPKM 176.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Zfand6 in Genome Data Viewer
Location:
1q31
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (147990099..148061221, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (138581002..138652052, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (146745850..146823762, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene cortexin domain containing 1 Neighboring gene fumarylacetoacetate hydrolase Neighboring gene uncharacterized LOC134485144 Neighboring gene RNA, U6 small nuclear 891 Neighboring gene uncharacterized LOC134485145 Neighboring gene uncharacterized LOC134485146

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Upregulation of neuronal zinc finger protein A20 expression is required for electroacupuncture to attenuate the cerebral inflammatory injury mediated by the nuclear factor-kB signaling pathway in cerebral ischemia/reperfusion rats. Zhan J, et al. J Neuroinflammation, 2016 Oct 3. PMID 27716383, Free PMC Article
  2. Zinc finger protein A20 inhibits maturation of dendritic cells resident in rat liver allograft. Dai FZ, et al. J Surg Res, 2013 Aug. PMID 23481562
  3. Overexpression of the nuclear factor kappaB inhibitor A20 is neurotoxic after an excitotoxic injury to the immature rat brain. Peluffo H, et al. Neurol Res, 2013 Apr. PMID 23336395
  4. The A20 gene protects kidneys from ischaemia/reperfusion injury by suppressing pro-inflammatory activation. Lutz J, et al. J Mol Med (Berl), 2008 Dec. PMID 18813897
  5. AWP1 binds to tumor necrosis factor receptor-associated factor 2 (TRAF2) and is involved in TRAF2-mediated nuclear factor-kappaB signaling. Chang EJ, et al. Int J Biochem Cell Biol, 2011 Nov. PMID 21810480

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. This study demonstrated that the Ischemia/reperfusion cortical neurons in MCAO rats are the main cell types that express A20, and there is a correlation between A20 expression and the suppression of neuroinflammation and the resulting neuroprotective effects.
    Title: Upregulation of neuronal zinc finger protein A20 expression is required for electroacupuncture to attenuate the cerebral inflammatory injury mediated by the nuclear factor-kB signaling pathway in cerebral ischemia/reperfusion rats.
  2. Zinc finger protein A20 inhibits maturation of dendritic cells resident in rat liver allograft.
    Title: Zinc finger protein A20 inhibits maturation of dendritic cells resident in rat liver allograft.
  3. A20 is expressed in astrocytes after brain damage, and its overexpression is neurotoxic for cortical neurons in basal mixed neuron-glia culture conditions and exacerbates postnatal brain excitotoxic damage.
    Title: Overexpression of the nuclear factor kappaB inhibitor A20 is neurotoxic after an excitotoxic injury to the immature rat brain.
  4. It was observed that A20 was induced in rat kidneys exposed to ischaemia/reperfusion.
    Title: The A20 gene protects kidneys from ischaemia/reperfusion injury by suppressing pro-inflammatory activation.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC94805

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables polyubiquitin modification-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables polyubiquitin modification-dependent protein binding ISO
Inferred from Sequence Orthology
more info
  
enables polyubiquitin modification-dependent protein binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to tumor necrosis factor ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to tumor necrosis factor ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein targeting to peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein targeting to peroxisome ISO
Inferred from Sequence Orthology
more info
  
involved_in protein targeting to peroxisome ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of canonical NF-kappaB signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within signal transduction ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
AN1-type zinc finger protein 6
Names
protein associated with PRK1
zinc finger A20 domain-containing protein 3
zinc finger, A20 domain containing 3
zinc finger, AN1-type domain 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007630.1 → NP_001007631.1  AN1-type zinc finger protein 6

    See identical proteins and their annotated locations for NP_001007631.1

    Status: PROVISIONAL

    Source sequence(s)
    BC076394
    UniProtKB/Swiss-Prot
    Q6DGF4
    UniProtKB/TrEMBL
    A0A8I5YCN4, A6JCP3
    Conserved Domains (2) summary
    smart00154
    Location:164 → 201
    ZnF_AN1; AN1-like Zinc finger
    pfam01754
    Location:12 → 34
    zf-A20; A20-like zinc finger

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    147990099..148061221 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006229507.4 → XP_006229569.1  AN1-type zinc finger protein 6 isoform X3

    See identical proteins and their annotated locations for XP_006229569.1

    UniProtKB/TrEMBL
    A0A8I6A8E7, A6JCP2
    Conserved Domains (2) summary
    smart00154
    Location:149 → 186
    ZnF_AN1; AN1-like Zinc finger
    pfam01754
    Location:12 → 34
    zf-A20; A20-like zinc finger

  2. XM_039105750.2 → XP_038961678.1  AN1-type zinc finger protein 6 isoform X1

    UniProtKB/Swiss-Prot
    Q6DGF4
    UniProtKB/TrEMBL
    A0A8I5YCN4, A6JCP3
    Conserved Domains (2) summary
    smart00154
    Location:164 → 201
    ZnF_AN1; AN1-like Zinc finger
    pfam01754
    Location:12 → 34
    zf-A20; A20-like zinc finger

  3. XM_063284852.1 → XP_063140922.1  AN1-type zinc finger protein 6 isoform X4

    Related
    ENSRNOP00000088600.2, ENSRNOT00000099671.2

  4. XM_006229505.3 → XP_006229567.1  AN1-type zinc finger protein 6 isoform X2

    See identical proteins and their annotated locations for XP_006229567.1

    UniProtKB/TrEMBL
    A0A8I5YCN4, A0A8I6AJP8
    Conserved Domains (2) summary
    smart00154
    Location:163 → 200
    ZnF_AN1; AN1-like Zinc finger
    pfam01754
    Location:12 → 34
    zf-A20; A20-like zinc finger

  5. XM_063284856.1 → XP_063140926.1  AN1-type zinc finger protein 6 isoform X4

  6. XM_063284824.1 → XP_063140894.1  AN1-type zinc finger protein 6 isoform X2

    UniProtKB/TrEMBL
    A0A8I6AJP8
    Related
    ENSRNOP00000095451.1, ENSRNOT00000100459.2

  7. XM_063284840.1 → XP_063140910.1  AN1-type zinc finger protein 6 isoform X3

    UniProtKB/TrEMBL
    A6JCP2

  8. XM_017588943.3 → XP_017444432.1  AN1-type zinc finger protein 6 isoform X1

    UniProtKB/Swiss-Prot
    Q6DGF4
    UniProtKB/TrEMBL
    A0A8I5YCN4, A6JCP3
    Conserved Domains (2) summary
    smart00154
    Location:164 → 201
    ZnF_AN1; AN1-like Zinc finger
    pfam01754
    Location:12 → 34
    zf-A20; A20-like zinc finger

  9. XM_063284854.1 → XP_063140924.1  AN1-type zinc finger protein 6 isoform X4

  10. XM_063284837.1 → XP_063140907.1  AN1-type zinc finger protein 6 isoform X2

    UniProtKB/TrEMBL
    A0A8I6AJP8

  11. XM_063284839.1 → XP_063140909.1  AN1-type zinc finger protein 6 isoform X3

    UniProtKB/TrEMBL
    A6JCP2

  12. XM_006229499.4 → XP_006229561.1  AN1-type zinc finger protein 6 isoform X1

    See identical proteins and their annotated locations for XP_006229561.1

    UniProtKB/Swiss-Prot
    Q6DGF4
    UniProtKB/TrEMBL
    A0A8I5YCN4, A6JCP3
    Conserved Domains (2) summary
    smart00154
    Location:164 → 201
    ZnF_AN1; AN1-like Zinc finger
    pfam01754
    Location:12 → 34
    zf-A20; A20-like zinc finger

  13. XM_063284825.1 → XP_063140895.1  AN1-type zinc finger protein 6 isoform X2

    UniProtKB/TrEMBL
    A0A8I6AJP8

  14. XM_063284841.1 → XP_063140911.1  AN1-type zinc finger protein 6 isoform X3

    UniProtKB/TrEMBL
    A6JCP2

  15. XM_006229506.5 → XP_006229568.1  AN1-type zinc finger protein 6 isoform X2

    See identical proteins and their annotated locations for XP_006229568.1

    UniProtKB/TrEMBL
    A0A8I5YCN4, A0A8I6AJP8
    Conserved Domains (2) summary
    smart00154
    Location:163 → 200
    ZnF_AN1; AN1-like Zinc finger
    pfam01754
    Location:12 → 34
    zf-A20; A20-like zinc finger

  16. XM_006229508.5 → XP_006229570.1  AN1-type zinc finger protein 6 isoform X3

    See identical proteins and their annotated locations for XP_006229570.1

    UniProtKB/TrEMBL
    A0A8I6A8E7, A6JCP2
    Conserved Domains (2) summary
    smart00154
    Location:149 → 186
    ZnF_AN1; AN1-like Zinc finger
    pfam01754
    Location:12 → 34
    zf-A20; A20-like zinc finger

  17. XM_006229500.5 → XP_006229562.1  AN1-type zinc finger protein 6 isoform X1

    See identical proteins and their annotated locations for XP_006229562.1

    UniProtKB/Swiss-Prot
    Q6DGF4
    UniProtKB/TrEMBL
    A0A8I5YCN4, A6JCP3
    Conserved Domains (2) summary
    smart00154
    Location:164 → 201
    ZnF_AN1; AN1-like Zinc finger
    pfam01754
    Location:12 → 34
    zf-A20; A20-like zinc finger

  18. XM_006229502.5 → XP_006229564.1  AN1-type zinc finger protein 6 isoform X1

    See identical proteins and their annotated locations for XP_006229564.1

    UniProtKB/Swiss-Prot
    Q6DGF4
    UniProtKB/TrEMBL
    A0A8I5YCN4, A6JCP3
    Conserved Domains (2) summary
    smart00154
    Location:164 → 201
    ZnF_AN1; AN1-like Zinc finger
    pfam01754
    Location:12 → 34
    zf-A20; A20-like zinc finger

  19. XM_063284842.1 → XP_063140912.1  AN1-type zinc finger protein 6 isoform X3

    UniProtKB/TrEMBL
    A6JCP2

  20. XM_006229504.4 → XP_006229566.1  AN1-type zinc finger protein 6 isoform X1

    See identical proteins and their annotated locations for XP_006229566.1

    UniProtKB/Swiss-Prot
    Q6DGF4
    UniProtKB/TrEMBL
    A0A8I5YCN4, A6JCP3
    Conserved Domains (2) summary
    smart00154
    Location:164 → 201
    ZnF_AN1; AN1-like Zinc finger
    pfam01754
    Location:12 → 34
    zf-A20; A20-like zinc finger

  21. XM_039105745.2 → XP_038961673.1  AN1-type zinc finger protein 6 isoform X1

    UniProtKB/Swiss-Prot
    Q6DGF4
    UniProtKB/TrEMBL
    A0A8I5YCN4, A6JCP3
    Conserved Domains (2) summary
    smart00154
    Location:164 → 201
    ZnF_AN1; AN1-like Zinc finger
    pfam01754
    Location:12 → 34
    zf-A20; A20-like zinc finger

  22. XM_063284851.1 → XP_063140921.1  AN1-type zinc finger protein 6 isoform X3

    UniProtKB/TrEMBL
    A6JCP2

  23. XM_063284809.1 → XP_063140879.1  AN1-type zinc finger protein 6 isoform X1

    UniProtKB/Swiss-Prot
    Q6DGF4
    UniProtKB/TrEMBL
    A6JCP3
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6DGF4.1 GenPept UniProtKB/Swiss-Prot:Q6DGF4

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