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Swap70 switching B-cell complex subunit SWAP70 [ Rattus norvegicus (Norway rat) ]

Gene ID: 293410, updated on 27-Nov-2024

Summary

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Official Symbol
Swap70provided by RGD
Official Full Name
switching B-cell complex subunit SWAP70provided by RGD
Primary source
RGD:1305579
See related
EnsemblRapid:ENSRNOG00000009910 AllianceGenome:RGD:1305579
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ATP binding activity and DNA binding activity. Predicted to be involved in several processes, including negative regulation of cell-cell adhesion mediated by integrin; positive regulation of mast cell chemotaxis; and regulation of actin filament organization. Predicted to act upstream of or within isotype switching. Predicted to be located in actin cytoskeleton and plasma membrane. Predicted to be active in cytoplasm; nucleus; and postsynapse. Orthologous to human SWAP70 (switching B cell complex subunit SWAP70). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 403.2), Kidney (RPKM 129.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Swap70 in Genome Data Viewer
Location:
1q33
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (173702338..173763540)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (164267588..164328796)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (174862683..174924101)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483773 Neighboring gene zinc finger protein 143 Neighboring gene RNA, U6 small nuclear 1168 Neighboring gene WEE1 G2 checkpoint kinase Neighboring gene SET binding factor 2 Neighboring gene N-lysine methyltransferase KMT5A-like Neighboring gene Y box binding protein 1, pseudogene 18 Neighboring gene lysine methyltransferase 5A, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. SWAP-70 regulates c-kit-induced mast cell activation, cell-cell adhesion, and migration. Sivalenka RR, et al. Mol Cell Biol, 2004 Dec. PMID 15542837, Free PMC Article
  2. The switch-associated protein 70 (SWAP-70) bundles actin filaments and contributes to the regulation of F-actin dynamics. Chacón-Martínez CA, et al. J Biol Chem, 2013 Oct 4. PMID 23921380, Free PMC Article
  3. A B-cell-specific DNA recombination complex. Borggrefe T, et al. J Biol Chem, 1998 Jul 3. PMID 9642267
  4. E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Guo Z, et al. Sci Signal, 2014 Dec 2. PMID 25468996, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in actin filament bundle assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within isotype switching ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of actin filament depolymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell-cell adhesion mediated by integrin ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of actin filament bundle assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of mast cell chemotaxis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of actin polymerization or depolymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein localization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within somatic cell DNA recombination ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
switch-associated protein 70
Names
SWA-70 protein
SWAP complex protein
SWAP switching B-cell complex 70
SWAP-70 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106288.1 → NP_001099758.1  switch-associated protein 70

    See identical proteins and their annotated locations for NP_001099758.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473956
    UniProtKB/TrEMBL
    A6I811, D3ZRE7
    Related
    ENSRNOP00000104275.1, ENSRNOT00000141310.1
    Conserved Domains (2) summary
    cd13273
    Location:204 → 313
    PH_SWAP-70; Switch-associated protein-70 Pleckstrin homology (PH) domain
    TIGR02168
    Location:332 → 549
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    173702338..173763540
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017588986.3 → XP_017444475.3  switch-associated protein 70 isoform X1

    Related
    ENSRNOP00000093197.2, ENSRNOT00000110741.2

  2. XM_063285799.1 → XP_063141869.1  switch-associated protein 70 isoform X2

    UniProtKB/TrEMBL
    A6I813
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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