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Gprc5b G protein-coupled receptor, class C, group 5, member B [ Rattus norvegicus (Norway rat) ]

Gene ID: 293546, updated on 27-Nov-2024

Summary

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Official Symbol
Gprc5bprovided by RGD
Official Full Name
G protein-coupled receptor, class C, group 5, member Bprovided by RGD
Primary source
RGD:1309510
See related
EnsemblRapid:ENSRNOG00000016013 AllianceGenome:RGD:1309510
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable protein kinase activator activity; protein kinase inhibitor activity; and protein tyrosine kinase binding activity. Predicted to be involved in several processes, including cell volume homeostasis; positive regulation of macromolecule metabolic process; and positive regulation of signal transduction. Predicted to act upstream of or within several processes, including glucose homeostasis; positive regulation of neuron projection development; and positive regulation of protein kinase activity. Predicted to be located in cell surface; cytosol; and nuclear lumen. Predicted to be part of receptor complex. Predicted to be active in several cellular components, including extracellular exosome; membrane raft; and plasma membrane. Human ortholog(s) of this gene implicated in megalencephalic leukoencephalopathy with subcortical cysts. Orthologous to human GPRC5B (G protein-coupled receptor class C group 5 member B). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 208.5), Heart (RPKM 65.9) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Gprc5b in Genome Data Viewer
Location:
1q35
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (182748247..182772711, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (173316904..173340933, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (188688743..188713724, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA44 Neighboring gene IQ motif containing K Neighboring gene uncharacterized LOC134485172 Neighboring gene uncharacterized LOC102550985 Neighboring gene uncharacterized LOC134485173 Neighboring gene G protein-coupled receptor 139

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Comparative characterization of GPRC5B and GPRC5CLacZ knockin mice; behavioral abnormalities in GPRC5B-deficient mice. Sano T, et al. Biochem Biophys Res Commun, 2011 Sep 2. PMID 21840300
  2. A flanking gene problem leads to the discovery of a Gprc5b splice variant predominantly expressed in C57Bl/6J mouse brain and in maturing neurons. Cool BH, et al. PLoS One, 2010 Apr 26. PMID 20436672, Free PMC Article
  3. The G protein-coupled receptor GPRC5B contributes to neurogenesis in the developing mouse neocortex. Kurabayashi N, et al. Development, 2013 Nov. PMID 24089469
  4. GPRC5B activates obesity-associated inflammatory signaling in adipocytes. Kim YJ, et al. Sci Signal, 2012 Nov 20. PMID 23169819
  5. Proteomic identification of exosomal LRG1: a potential urinary biomarker for detecting NSCLC. Li Y, et al. Electrophoresis, 2011 Aug. PMID 21557262

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in cell volume homeostasis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within glucose homeostasis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within locomotory behavior ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of macrophage cytokine production ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in extracellular exosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular exosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
is_active_in membrane raft ISO
Inferred from Sequence Orthology
more info
  
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
G-protein coupled receptor family C group 5 member B
Names
G protein-coupled receptor, family C, group 5, member B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001398762.1 → NP_001385691.1  G-protein coupled receptor family C group 5 member B precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A6I8K3
    Related
    ENSRNOP00000072971.2, ENSRNOT00000082192.3
    Conserved Domains (1) summary
    cd15278
    Location:46 → 289
    7tmC_RAIG2_GPRC5B; retinoic acid-inducible orphan G-protein-coupled receptor 2; class C family of seven-transmembrane G protein-coupled receptors, group 5, member B

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    182748247..182772711 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063286405.1 → XP_063142475.1  G-protein coupled receptor family C group 5 member B isoform X1

    Related
    ENSRNOP00000112772.1, ENSRNOT00000159910.1

  2. XM_039107629.2 → XP_038963557.1  G-protein coupled receptor family C group 5 member B isoform X2

    UniProtKB/TrEMBL
    A0A0G2K4B0, D4A3F5
    Related
    ENSRNOP00000061518.2, ENSRNOT00000065892.4
    Conserved Domains (1) summary
    cd15278
    Location:66 → 309
    7tmC_RAIG2_GPRC5B; retinoic acid-inducible orphan G-protein-coupled receptor 2; class C family of seven-transmembrane G protein-coupled receptors, group 5, member B

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001106304.1: Suppressed sequence

    Description
    NM_001106304.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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