Brsk2 BR serine/threonine kinase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Brsk2provided by RGD
Full Name: BR serine/threonine kinase 2provided by RGD
Primary source: RGD:1566256
See related: EnsemblRapid:ENSRNOG00000020021 AllianceGenome:RGD:1566256
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables protein serine/threonine kinase activity. Predicted to be involved in several processes, including G2/M transition of mitotic cell cycle; cytoskeleton organization; and intracellular signal transduction. Predicted to act upstream of or within neuron projection morphogenesis and peptidyl-serine phosphorylation. Located in distal axon. Orthologous to human BRSK2 (BR serine/threonine kinase 2). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Brain (RPKM 120.1) and Spleen (RPKM 6.7) See more
Orthologs: human mouse all
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Genomic context

Location:: 1q41

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (206465040..206518156)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (197035505..197088624)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (214918757..214940883)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Glucose and incretin stimulate insulin secretion through the phosphorylation of GDIalpha at Ser174 by SAD-A, which leads to the activation of Rho GTPases, culminating in insulin exocytosis.
Title: SAD-A Promotes Glucose-Stimulated Insulin Secretion Through Phosphorylation and Inhibition of GDIα in Male Islet β Cells.
The regulation of Wee1 by SadA and SadB kinases is essential for the differentiation of polarized neurons.
Title: Persistence of the cell-cycle checkpoint kinase Wee1 in SadA- and SadB-deficient neurons disrupts neuronal polarity.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH142958 (e-PCR)
- UniSTS:232205

RH143841 (e-PCR)
- UniSTS:233087

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables ATPase binding	IEA Inferred from Electronic Annotation more info
enables ATPase binding	ISO Inferred from Sequence Orthology more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info
enables tau-protein kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables tau-protein kinase activity	IEA Inferred from Electronic Annotation more info
enables tau-protein kinase activity	ISO Inferred from Sequence Orthology more info
enables tau-protein kinase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in DNA damage response	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in ERAD pathway	IEA Inferred from Electronic Annotation more info
involved_in ERAD pathway	ISO Inferred from Sequence Orthology more info
involved_in G2/M transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in G2/M transition of mitotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in G2/M transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in actin cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in axonogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in axonogenesis	IEA Inferred from Electronic Annotation more info
involved_in axonogenesis	ISO Inferred from Sequence Orthology more info
involved_in axonogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in establishment of cell polarity	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of cell polarity	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within establishment of cell polarity	ISO Inferred from Sequence Orthology more info
involved_in establishment of cell polarity	ISO Inferred from Sequence Orthology more info
involved_in establishment of cell polarity	ISS Inferred from Sequence or Structural Similarity more info
involved_in exocytosis	IEA Inferred from Electronic Annotation more info
involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IEA Inferred from Electronic Annotation more info
involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	ISO Inferred from Sequence Orthology more info
involved_in microtubule cytoskeleton organization involved in establishment of planar polarity	IEA Inferred from Electronic Annotation more info
involved_in microtubule cytoskeleton organization involved in establishment of planar polarity	ISO Inferred from Sequence Orthology more info
involved_in mitotic G2 DNA damage checkpoint signaling	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in mitotic cell cycle checkpoint signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in neuron differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron projection morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in regulation of axonogenesis	IEA Inferred from Electronic Annotation more info
involved_in regulation of axonogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of insulin secretion involved in cellular response to glucose stimulus	IEA Inferred from Electronic Annotation more info
involved_in regulation of insulin secretion involved in cellular response to glucose stimulus	ISO Inferred from Sequence Orthology more info
involved_in regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in response to UV	ISS Inferred from Sequence or Structural Similarity more info	PubMed
NOT involved_in response to ionizing radiation	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in distal axon	IMP Inferred from Mutant Phenotype more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: serine/threonine-protein kinase BRSK2

Names: BR serine/threonine-protein kinase 2; brain serine/threonine kinase 2; brain-specific serine/threonine-protein kinase 2; serine/threonine-protein kinase BRSK2-like; serine/threonine-protein kinase SAD-A

NP_001406495.1

EC 2.7.11.1

EC 2.7.11.26

XP_038957200.1

EC 2.7.11.1

EC 2.7.11.26

XP_038957201.1

EC 2.7.11.1

EC 2.7.11.26

XP_038957202.1

EC 2.7.11.1

EC 2.7.11.26

XP_038957203.1

EC 2.7.11.1

EC 2.7.11.26

XP_038957204.1

EC 2.7.11.1

EC 2.7.11.26

XP_038957206.1

EC 2.7.11.1

EC 2.7.11.26

XP_038957207.1

EC 2.7.11.1

EC 2.7.11.26

XP_038957208.1

EC 2.7.11.1

EC 2.7.11.26

XP_038957209.1

EC 2.7.11.1

EC 2.7.11.26

XP_038957210.1

EC 2.7.11.1

EC 2.7.11.26

XP_038957212.1

EC 2.7.11.1

EC 2.7.11.26

XP_038957213.1

EC 2.7.11.1

EC 2.7.11.26

XP_038957214.1

EC 2.7.11.1

EC 2.7.11.26

XP_038957215.1

EC 2.7.11.1

EC 2.7.11.26

XP_063142736.1

EC 2.7.11.1

EC 2.7.11.26

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001419566.1 → NP_001406495.1 serine/threonine-protein kinase BRSK2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

Related

ENSRNOP00000097899.2, ENSRNOT00000116048.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

206465040..206518156

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039101272.2 → XP_038957200.1 serine/threonine-protein kinase BRSK2 isoform X1

Conserved Domains (2) summary

cd14340
Location:298 → 351

UBA_BRSK; UBA domain found in serine/threonine-protein kinase BRSK1, BRSK2 and similar proteins

cd14081
Location:18 → 271

STKc_BRSK1_2; Catalytic domain of Brain-specific serine/threonine-protein kinases 1 and 2
XM_039101273.2 → XP_038957201.1 serine/threonine-protein kinase BRSK2 isoform X2

Related

ENSRNOP00000078625.2, ENSRNOT00000113716.2

Conserved Domains (2) summary

cd14340
Location:298 → 351

UBA_BRSK; UBA domain found in serine/threonine-protein kinase BRSK1, BRSK2 and similar proteins

cd14081
Location:18 → 271

STKc_BRSK1_2; Catalytic domain of Brain-specific serine/threonine-protein kinases 1 and 2
XM_039101274.2 → XP_038957202.1 serine/threonine-protein kinase BRSK2 isoform X3

Conserved Domains (2) summary

cd14340
Location:298 → 351

UBA_BRSK; UBA domain found in serine/threonine-protein kinase BRSK1, BRSK2 and similar proteins

cd14081
Location:18 → 271

STKc_BRSK1_2; Catalytic domain of Brain-specific serine/threonine-protein kinases 1 and 2
XM_039101275.2 → XP_038957203.1 serine/threonine-protein kinase BRSK2 isoform X4

UniProtKB/TrEMBL

A0A8I6GM96

Conserved Domains (2) summary

cd14340
Location:298 → 351

UBA_BRSK; UBA domain found in serine/threonine-protein kinase BRSK1, BRSK2 and similar proteins

cd14081
Location:18 → 271

STKc_BRSK1_2; Catalytic domain of Brain-specific serine/threonine-protein kinases 1 and 2
XM_039101281.2 → XP_038957209.1 serine/threonine-protein kinase BRSK2 isoform X7

Conserved Domains (2) summary

cd14340
Location:298 → 351

UBA_BRSK; UBA domain found in serine/threonine-protein kinase BRSK1, BRSK2 and similar proteins

cd14081
Location:18 → 271

STKc_BRSK1_2; Catalytic domain of Brain-specific serine/threonine-protein kinases 1 and 2
XM_039101276.2 → XP_038957204.1 serine/threonine-protein kinase BRSK2 isoform X5

Conserved Domains (2) summary

cd14340
Location:298 → 351

UBA_BRSK; UBA domain found in serine/threonine-protein kinase BRSK1, BRSK2 and similar proteins

cd14081
Location:18 → 271

STKc_BRSK1_2; Catalytic domain of Brain-specific serine/threonine-protein kinases 1 and 2
XM_039101279.2 → XP_038957207.1 serine/threonine-protein kinase BRSK2 isoform X6

UniProtKB/TrEMBL

A0A8I6ABA6

Conserved Domains (2) summary

cd14340
Location:298 → 351

UBA_BRSK; UBA domain found in serine/threonine-protein kinase BRSK1, BRSK2 and similar proteins

cd14081
Location:18 → 271

STKc_BRSK1_2; Catalytic domain of Brain-specific serine/threonine-protein kinases 1 and 2
XM_039101284.2 → XP_038957212.1 serine/threonine-protein kinase BRSK2 isoform X10

UniProtKB/TrEMBL

A0A8I5ZQ20

Related

ENSRNOP00000080546.1, ENSRNOT00000117225.2

Conserved Domains (2) summary

cd14340
Location:298 → 351

UBA_BRSK; UBA domain found in serine/threonine-protein kinase BRSK1, BRSK2 and similar proteins

cd14081
Location:18 → 271

STKc_BRSK1_2; Catalytic domain of Brain-specific serine/threonine-protein kinases 1 and 2
XM_039101285.2 → XP_038957213.1 serine/threonine-protein kinase BRSK2 isoform X11

Conserved Domains (2) summary

cd14340
Location:298 → 351

UBA_BRSK; UBA domain found in serine/threonine-protein kinase BRSK1, BRSK2 and similar proteins

cd14081
Location:18 → 271

STKc_BRSK1_2; Catalytic domain of Brain-specific serine/threonine-protein kinases 1 and 2
XM_039101278.2 → XP_038957206.1 serine/threonine-protein kinase BRSK2 isoform X6

UniProtKB/TrEMBL

A0A8I6ABA6

Conserved Domains (2) summary

cd14340
Location:298 → 351

UBA_BRSK; UBA domain found in serine/threonine-protein kinase BRSK1, BRSK2 and similar proteins

cd14081
Location:18 → 271

STKc_BRSK1_2; Catalytic domain of Brain-specific serine/threonine-protein kinases 1 and 2
XM_039101280.2 → XP_038957208.1 serine/threonine-protein kinase BRSK2 isoform X6

UniProtKB/TrEMBL

A0A8I6ABA6

Conserved Domains (2) summary

cd14340
Location:298 → 351

UBA_BRSK; UBA domain found in serine/threonine-protein kinase BRSK1, BRSK2 and similar proteins

cd14081
Location:18 → 271

STKc_BRSK1_2; Catalytic domain of Brain-specific serine/threonine-protein kinases 1 and 2
XM_063286666.1 → XP_063142736.1 serine/threonine-protein kinase BRSK2 isoform X9

UniProtKB/TrEMBL

A0A8I5ZLC7

Related

ENSRNOP00000090176.2, ENSRNOT00000113212.2
XM_039101286.2 → XP_038957214.1 serine/threonine-protein kinase BRSK2 isoform X12

Conserved Domains (2) summary

cd14340
Location:298 → 351

UBA_BRSK; UBA domain found in serine/threonine-protein kinase BRSK1, BRSK2 and similar proteins

cd14081
Location:18 → 271

STKc_BRSK1_2; Catalytic domain of Brain-specific serine/threonine-protein kinases 1 and 2
XM_039101282.2 → XP_038957210.1 serine/threonine-protein kinase BRSK2 isoform X8

Conserved Domains (2) summary

cd14340
Location:217 → 270

UBA_BRSK; UBA domain found in serine/threonine-protein kinase BRSK1, BRSK2 and similar proteins

cl21453
Location:12 → 190

PKc_like; Protein Kinases, catalytic domain
XM_039101287.2 → XP_038957215.1 serine/threonine-protein kinase BRSK2 isoform X13

Conserved Domains (1) summary

cd14340
Location:33 → 86

UBA_BRSK; UBA domain found in serine/threonine-protein kinase BRSK1, BRSK2 and similar proteins