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Brms1 BRMS1, transcriptional repressor and anoikis regulator [ Rattus norvegicus (Norway rat) ]

Gene ID: 293668, updated on 14-Nov-2024

Summary

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Symbol
Brms1provided by RGD
Full Name
BRMS1, transcriptional repressor and anoikis regulatorprovided by RGD
Primary source
RGD:1311057
See related
EnsemblRapid:ENSRNOG00000020117 AllianceGenome:RGD:1311057
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable NF-kappaB binding activity and histone deacetylase binding activity. Predicted to be involved in positive regulation of anoikis; positive regulation of protein deacetylation; and regulation of DNA-templated transcription. Predicted to be located in cytoplasm and nucleus. Predicted to be part of Sin3-type complex. Orthologous to human BRMS1 (BRMS1 transcriptional repressor and anoikis regulator). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Testes (RPKM 422.3), Thymus (RPKM 305.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Brms1 in Genome Data Viewer
Location:
1q43
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (211775142..211784411)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (202345766..202355028)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (220325352..220334616)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene transfer RNA serine (anticodon GCU) 2 Neighboring gene beta-1,4-glucuronyltransferase 1 Neighboring gene Ras and Rab interactor 1 Neighboring gene CD248 molecule

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Sorting nexin 6 interacts with breast cancer metastasis suppressor-1 and promotes transcriptional repression. Rivera J, et al. J Cell Biochem, 2010 Dec 15. PMID 20830743
  2. Identification and characterization of the murine ortholog (brms1) of breast-cancer metastasis suppressor 1 (BRMS1). Samant RS, et al. Int J Cancer, 2002 Jan 1. PMID 11774238
  3. Breast cancer metastasis suppressor 1 functions as a corepressor by enhancing histone deacetylase 1-mediated deacetylation of RelA/p65 and promoting apoptosis. Liu Y, et al. Mol Cell Biol, 2006 Dec. PMID 17000776, Free PMC Article
  4. Reduced metastasis-suppressor gene mRNA-expression in breast cancer brain metastases. Stark AM, et al. J Cancer Res Clin Oncol, 2005 Mar. PMID 15592684
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC95128

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables NF-kappaB binding ISO
Inferred from Sequence Orthology
more info
  
enables histone deacetylase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of NF-kappaB transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of anoikis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of anoikis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of protein deacetylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein deacetylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of Sin3-type complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
breast cancer metastasis-suppressor 1 homolog
Names
breast cancer metastasis suppressor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009605.1 → NP_001009605.1  breast cancer metastasis-suppressor 1 homolog

    See identical proteins and their annotated locations for NP_001009605.1

    Status: PROVISIONAL

    Source sequence(s)
    BC088469
    UniProtKB/Swiss-Prot
    Q5M7T3
    UniProtKB/TrEMBL
    A0A8L2QEL2, A6HZ16
    Related
    ENSRNOP00000027258.6, ENSRNOT00000027258.6
    Conserved Domains (1) summary
    pfam08598
    Location:60 → 177
    Sds3; Sds3-like

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    211775142..211784411
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063286834.1 → XP_063142904.1  breast cancer metastasis-suppressor 1 homolog isoform X2

  2. XM_063286835.1 → XP_063142905.1  breast cancer metastasis-suppressor 1 homolog isoform X3

    UniProtKB/Swiss-Prot
    Q5M7T3
    UniProtKB/TrEMBL
    A6HZ16

  3. XM_063286829.1 → XP_063142899.1  breast cancer metastasis-suppressor 1 homolog isoform X1

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5M7T3.1 GenPept UniProtKB/Swiss-Prot:Q5M7T3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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