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Lpxn leupaxin [ Rattus norvegicus (Norway rat) ]

Gene ID: 293783, updated on 27-Nov-2024

Summary

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Official Symbol
Lpxnprovided by RGD
Official Full Name
leupaxinprovided by RGD
Primary source
RGD:1304981
See related
EnsemblRapid:ENSRNOG00000012611 AllianceGenome:RGD:1304981
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable transcription coregulator activity. Predicted to be involved in several processes, including negative regulation of B cell receptor signaling pathway; substrate adhesion-dependent cell spreading; and transforming growth factor beta receptor signaling pathway. Predicted to be located in several cellular components, including focal adhesion; nuclear speck; and podosome. Orthologous to human LPXN (leupaxin). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 635.0), Spleen (RPKM 313.9) and 4 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Lpxn in Genome Data Viewer
Location:
1q43
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (219353319..219387743)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (209928297..209963085)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (229642437..229674129)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene glycine-N-acyltransferase-like 2 Neighboring gene ciliary neurotrophic factor Neighboring gene zinc finger protein 91 Neighboring gene small nucleolar RNA U13 Neighboring gene olfactory receptor family 5 subfamily B member 21

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Leupaxin is similar to paxillin in focal adhesion targeting and tyrosine phosphorylation but has distinct roles in cell adhesion and spreading. Chen PW, et al. Cell Adh Migr, 2010 Oct-Dec. PMID 20543562, Free PMC Article
  2. Leupaxin, a novel coactivator of the androgen receptor, is expressed in prostate cancer and plays a role in adhesion and invasion of prostate carcinoma cells. Kaulfuss S, et al. Mol Endocrinol, 2008 Jul. PMID 18451096, Free PMC Article
  3. LIM domain-containing adaptor, leupaxin, localizes in focal adhesion and suppresses the integrin-induced tyrosine phosphorylation of paxillin. Tanaka T, et al. Cancer Sci, 2010 Feb. PMID 19917054, Free PMC Article
  4. The LIM protein leupaxin is enriched in smooth muscle and functions as an serum response factor cofactor to induce smooth muscle cell gene transcription. Sundberg-Smith LJ, et al. Circ Res, 2008 Jun 20. PMID 18497331, Free PMC Article
  5. Leupaxin negatively regulates B cell receptor signaling. Chew V, et al. J Biol Chem, 2007 Sep 14. PMID 17640867

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC108942

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transcription coregulator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in endothelial cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of B cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of B cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell adhesion mediated by integrin ISO
Inferred from Sequence Orthology
more info
  
involved_in substrate adhesion-dependent cell spreading IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transforming growth factor beta receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in podosome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
leupaxin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009649.1 → NP_001009649.1  leupaxin

    See identical proteins and their annotated locations for NP_001009649.1

    Status: PROVISIONAL

    Source sequence(s)
    BC088217
    UniProtKB/TrEMBL
    A6I0F1, Q5M852
    Related
    ENSRNOP00000017109.4, ENSRNOT00000017109.8
    Conserved Domains (3) summary
    cd09339
    Location:329 → 380
    LIM4_Paxillin_like; The fourth LIM domain of the Paxillin-like protein family
    cl01815
    Location:86 → 172
    DUF1018; Protein of unknown function (DUF1018)
    cl02475
    Location:150 → 204
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    219353319..219387743
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039108720.2 → XP_038964648.1  leupaxin isoform X4

    Conserved Domains (2) summary
    cd09339
    Location:233 → 284
    LIM4_Paxillin_like; The fourth LIM domain of the Paxillin-like protein family
    cl02475
    Location:54 → 108
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  2. XM_039108719.2 → XP_038964647.1  leupaxin isoform X3

    UniProtKB/TrEMBL
    A0A8I5YCK6
    Conserved Domains (3) summary
    cd09339
    Location:331 → 382
    LIM4_Paxillin_like; The fourth LIM domain of the Paxillin-like protein family
    cd09406
    Location:152 → 206
    LIM1_Leupaxin; The first LIM domain of Leupaxin
    cl02475
    Location:213 → 264
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  3. XM_039108725.2 → XP_038964653.1  leupaxin isoform X2

    UniProtKB/TrEMBL
    A0A8I5YCK6
    Related
    ENSRNOP00000111449.1, ENSRNOT00000152331.1
    Conserved Domains (3) summary
    cd09339
    Location:334 → 385
    LIM4_Paxillin_like; The fourth LIM domain of the Paxillin-like protein family
    cd09406
    Location:155 → 209
    LIM1_Leupaxin; The first LIM domain of Leupaxin
    cl02475
    Location:216 → 267
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  4. XM_063286990.1 → XP_063143060.1  leupaxin isoform X4

  5. XM_039108715.2 → XP_038964643.1  leupaxin isoform X1

    UniProtKB/TrEMBL
    A0A8I5YCK6
    Related
    ENSRNOP00000077943.2, ENSRNOT00000095033.2
    Conserved Domains (3) summary
    cd09339
    Location:341 → 392
    LIM4_Paxillin_like; The fourth LIM domain of the Paxillin-like protein family
    cd09406
    Location:162 → 216
    LIM1_Leupaxin; The first LIM domain of Leupaxin
    cl02475
    Location:223 → 274
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
Nucleotide Protein Strain
Heading Accession and Version

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