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Srpk3 SRSF protein kinase 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 293854, updated on 27-Nov-2024

Summary

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Official Symbol
Srpk3provided by RGD
Official Full Name
SRSF protein kinase 3provided by RGD
Primary source
RGD:727856
See related
EnsemblRapid:ENSRNOG00000054548 AllianceGenome:RGD:727856
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Mssk1; Stk23
Summary
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in muscle tissue development. Predicted to act upstream of or within protein phosphorylation and skeletal muscle tissue development. Orthologous to human SRPK3 (SRSF protein kinase 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Muscle (RPKM 239.6), Heart (RPKM 179.0) and 4 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Srpk3 in Genome Data Viewer
Location:
Xq37
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (156661888..156666537)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (151510452..151515208)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (157008773..157014342, complement)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA70 Neighboring gene plexin B3 Neighboring gene isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma Neighboring gene signal sequence receptor subunit 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Centronuclear myopathy in mice lacking a novel muscle-specific protein kinase transcriptionally regulated by MEF2. Nakagawa O, et al. Genes Dev, 2005 Sep 1. PMID 16140986, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in muscle tissue development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within skeletal muscle tissue development ISO
Inferred from Sequence Orthology
more info
  
involved_in spliceosomal complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
SRSF protein kinase 3
Names
SFRS protein kinase 3
muscle-specific serine kinase 1
muscle-specific serine kinase 1; MSSK1
serine arginine rich protein-specific kinase 3
serine/threonine kinase 23
serine/threonine-protein kinase SRPK3
XP_006229620.1
XP_006229621.1
XP_006229622.1
XP_006229623.1
XP_008771839.1
XP_008771840.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001433945.1 → NP_001420874.1  SRSF protein kinase 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    156661888..156666537
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006229558.5 → XP_006229620.1  SRSF protein kinase 3 isoform X1

    UniProtKB/TrEMBL
    A6KRV7
    Conserved Domains (2) summary
    smart00220
    Location:102 → 591
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:91 → 591
    PKc_like; Protein Kinases, catalytic domain

  2. XM_006229559.5 → XP_006229621.1  SRSF protein kinase 3 isoform X2

    UniProtKB/TrEMBL
    A6KRV7
    Related
    ENSRNOP00000075400.2, ENSRNOT00000082711.3
    Conserved Domains (2) summary
    smart00220
    Location:102 → 590
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:91 → 590
    PKc_like; Protein Kinases, catalytic domain

  3. XM_008773617.4 → XP_008771839.1  SRSF protein kinase 3 isoform X5

    UniProtKB/TrEMBL
    A6KRV7
    Conserved Domains (2) summary
    smart00220
    Location:102 → 526
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:91 → 526
    PKc_like; Protein Kinases, catalytic domain

  4. XM_006229560.5 → XP_006229622.1  SRSF protein kinase 3 isoform X3

    UniProtKB/TrEMBL
    A6KRV7
    Conserved Domains (2) summary
    smart00220
    Location:102 → 589
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14218
    Location:91 → 589
    STKc_SRPK3; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 3

  5. XM_006229561.5 → XP_006229623.1  SRSF protein kinase 3 isoform X4

    UniProtKB/TrEMBL
    A0A0G2KAH6, A6KRV7
    Conserved Domains (2) summary
    smart00220
    Location:102 → 588
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14218
    Location:91 → 588
    STKc_SRPK3; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 3

  6. XM_008773618.4 → XP_008771840.1  SRSF protein kinase 3 isoform X6

    UniProtKB/TrEMBL
    A6KRV7
    Conserved Domains (2) summary
    smart00220
    Location:102 → 524
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:91 → 524
    PKc_like; Protein Kinases, catalytic domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_184045.2: Suppressed sequence

    Description
    NM_184045.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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