Sorcs3 sortilin-related VPS10 domain containing receptor 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sorcs3provided by RGD
Official Full Name: sortilin-related VPS10 domain containing receptor 3provided by RGD
Primary source: RGD:1310974
See related: EnsemblRapid:ENSRNOG00000028832 AllianceGenome:RGD:1310974
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to be involved in postsynaptic modulation of chemical synaptic transmission. Predicted to act upstream of or within learning; memory; and regulation of long-term synaptic depression. Predicted to be located in postsynaptic density. Predicted to be active in glutamatergic synapse and postsynaptic density membrane. Orthologous to human SORCS3 (sortilin related VPS10 domain containing receptor 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 56.6), Kidney (RPKM 4.8) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 1q55

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (257040442..257675259)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (247099178..247734027)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (267986305..268620331)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

D1Hmgc2 (e-PCR)
- UniSTS:260878

D1Got247 (e-PCR)
- UniSTS:113453

D1Got249 (e-PCR)
- UniSTS:114901

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within learning	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within memory	ISO Inferred from Sequence Orthology more info
involved_in postsynaptic modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of long-term synaptic depression	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic density membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: VPS10 domain-containing receptor SorCS3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106367.3 → NP_001099837.2 VPS10 domain-containing receptor SorCS3 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

D4A2I9

Related

ENSRNOP00000059656.4, ENSRNOT00000065001.5

Conserved Domains (3) summary

smart00602
Location:216 → 814

VPS10; VPS10 domain

pfam00801
Location:828 → 901

PKD; PKD domain

pfam15901
Location:658 → 814

Sortilin_C; Sortilin, neurotensin receptor 3, C-terminal