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Papss2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 294103, updated on 14-Nov-2024

Summary

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Official Symbol
Papss2provided by RGD
Official Full Name
3'-phosphoadenosine 5'-phosphosulfate synthase 2provided by RGD
Primary source
RGD:1307012
See related
EnsemblRapid:ENSRNOG00000011068 AllianceGenome:RGD:1307012
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable adenylylsulfate kinase activity and sulfate adenylyltransferase (ATP) activity. Predicted to be involved in 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process; hormone metabolic process; and sulfate assimilation. Predicted to act upstream of or within blood coagulation and bone development. Predicted to be located in cytosol. Human ortholog(s) of this gene implicated in spondyloepimetaphyseal dysplasia, Pakistani type. Orthologous to human PAPSS2 (3'-phosphoadenosine 5'-phosphosulfate synthase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Liver (RPKM 267.4), Kidney (RPKM 113.8) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Papss2 in Genome Data Viewer
Location:
1q52
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (239867597..239952614)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (230454314..230539332)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (251145264..251230716)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene U4 spliceosomal RNA Neighboring gene multiple inositol-polyphosphate phosphatase 1 Neighboring gene uncharacterized LOC134485221 Neighboring gene U2 spliceosomal RNA Neighboring gene uncharacterized LOC134485222 Neighboring gene ATPase family, AAA domain containing 1 Neighboring gene glutathione S-transferase P 1-like Neighboring gene phosphatase and tensin homolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Genomic organization of the mouse and human genes encoding the ATP sulfurylase/adenosine 5'-phosphosulfate kinase isoform SK2. Kurima K, et al. J Biol Chem, 1999 Nov 19. PMID 10559207
  2. The growth of femur and tibia in three genetically distinct chondrodystrophic mutants of the house mouse. Johnson DR. J Anat, 1978 Feb. PMID 624676, Free PMC Article
  3. Molecular markers near the mouse brachymorphic (bm) gene, which affects connective tissues and bleeding time. Rusiniak ME, et al. Mamm Genome, 1996 Feb. PMID 8835524
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC189455

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables adenylylsulfate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables adenylylsulfate kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables selenate adenylyltransferase (ATP) activity TAS
Traceable Author Statement
more info
  
enables sulfate adenylyltransferase (ATP) activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within blood coagulation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within bone development ISO
Inferred from Sequence Orthology
more info
  
involved_in hormone metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in sulfate assimilation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sulfate assimilation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within sulfate assimilation ISO
Inferred from Sequence Orthology
more info
  
involved_in sulfate assimilation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2
NP_001099845.2
XP_006231336.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106375.2 → NP_001099845.2  bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2

    See identical proteins and their annotated locations for NP_001099845.2

    Status: PROVISIONAL

    Source sequence(s)
    BC169061
    UniProtKB/TrEMBL
    B5DFH4
    Related
    ENSRNOP00000074860.2, ENSRNOT00000083555.3
    Conserved Domains (3) summary
    cd00517
    Location:243 → 606
    ATPS; ATP-sulfurylase
    cd02027
    Location:43 → 193
    APSK; Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form important for the assimilation of ...
    TIGR00339
    Location:225 → 605
    sopT; ATP sulphurylase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    239867597..239952614
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006231274.5 → XP_006231336.1  bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K950
    Related
    ENSRNOP00000014979.5, ENSRNOT00000014979.7
    Conserved Domains (3) summary
    cd00517
    Location:243 → 611
    ATPS; ATP-sulfurylase
    cd02027
    Location:43 → 193
    APSK; Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form important for the assimilation of ...
    TIGR00339
    Location:225 → 610
    sopT; ATP sulphurylase
Nucleotide Protein Strain
Heading Accession and Version

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