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Chrne cholinergic receptor nicotinic epsilon subunit [ Rattus norvegicus (Norway rat) ]

Gene ID: 29422, updated on 4-Jan-2025

Summary

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Official Symbol
Chrneprovided by RGD
Official Full Name
cholinergic receptor nicotinic epsilon subunitprovided by RGD
Primary source
RGD:2353
See related
EnsemblRapid:ENSRNOG00000003777 AllianceGenome:RGD:2353
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
nAChR
Summary
Enables acetylcholine-gated monoatomic cation-selective channel activity. Involved in monoatomic cation transport and skeletal muscle contraction. Part of acetylcholine-gated channel complex. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome; congenital myasthenic syndrome 4A; congenital myasthenic syndrome 4B; and congenital myasthenic syndrome 4C. Orthologous to human CHRNE (cholinergic receptor nicotinic epsilon subunit). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Testes (RPKM 217.3), Muscle (RPKM 38.9) and 5 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Chrne in Genome Data Viewer
Location:
10q24
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (55829835..55838853, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (55331211..55339923, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (57238960..57246750, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene phospholipase D2 Neighboring gene uncharacterized LOC134480817 Neighboring gene misshapen-like kinase 1 Neighboring gene similar to human chromosome 17 open reading frame 107 Neighboring gene glycoprotein Ib platelet subunit alpha Neighboring gene ribosomal protein L36A, pseudogene 2 Neighboring gene solute carrier family 25 member 11

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Calcium-dependent regulation of rat and chick muscle nicotinic acetylcholine receptor (nAChR) gene expression. Walke W, et al. J Biol Chem, 1994 Jul 29. PMID 8034713
  2. Nucleotide sequence of the rat muscle acetylcholine receptor epsilon-subunit. Criado M, et al. Nucleic Acids Res, 1988 Nov 25. PMID 3205730, Free PMC Article
  3. Differential regulation of muscle acetylcholine receptor gamma- and epsilon-subunit mRNAs. Witzemann V, et al. FEBS Lett, 1987 Oct 19. PMID 3666131
  4. Congenital myasthenic syndrome caused by prolonged acetylcholine receptor channel openings due to a mutation in the M2 domain of the epsilon subunit. Ohno K, et al. Proc Natl Acad Sci U S A, 1995 Jan 31. PMID 7531341, Free PMC Article
  5. A novel mode-of-action mediated by the fetal muscle nicotinic acetylcholine receptor resulting in developmental toxicity in rats. Rasoulpour RJ, et al. Toxicol Sci, 2012 Jun. PMID 22461452

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables acetylcholine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acetylcholine-gated monoatomic cation-selective channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables acetylcholine-gated monoatomic cation-selective channel activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to acetylcholine-gated monoatomic cation-selective channel activity ISO
Inferred from Sequence Orthology
more info
  
enables excitatory extracellular ligand-gated monoatomic ion channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in acetylcholine receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in excitatory postsynaptic potential IEA
Inferred from Electronic Annotation
more info
  
involved_in membrane depolarization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in monoatomic cation transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in monoatomic ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of membrane potential ISO
Inferred from Sequence Orthology
more info
  
involved_in skeletal muscle contraction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in synaptic transmission, cholinergic IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of acetylcholine-gated channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of acetylcholine-gated channel complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in neuromuscular junction IEA
Inferred from Electronic Annotation
more info
  
is_active_in neuromuscular junction ISO
Inferred from Sequence Orthology
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
  
located_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic specialization membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
acetylcholine receptor subunit epsilon
Names
acetylcholine receptor epsilon
cholinergic receptor, nicotinic epsilon
cholinergic receptor, nicotinic, epsilon (muscle)
cholinergic receptor, nicotinic, epsilon polypeptide
epsilon-subunit
gene for acetylcholine receptor epsilon subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017194.1 → NP_058890.1  acetylcholine receptor subunit epsilon precursor

    See identical proteins and their annotated locations for NP_058890.1

    Status: PROVISIONAL

    Source sequence(s)
    X74836
    UniProtKB/Swiss-Prot
    P09660, Q6LAD4
    Related
    ENSRNOP00000005050.2, ENSRNOT00000005050.6
    Conserved Domains (3) summary
    TIGR00860
    Location:15 → 476
    LIC; Cation transporter family protein
    pfam02931
    Location:24 → 240
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:247 → 475
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    55829835..55838853 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017597172.3 → XP_017452661.1  acetylcholine receptor subunit epsilon isoform X2

  2. XM_017597171.3 → XP_017452660.1  acetylcholine receptor subunit epsilon isoform X1

  3. XM_039085740.2 → XP_038941668.1  acetylcholine receptor subunit epsilon isoform X3

    UniProtKB/TrEMBL
    A6HG68, G3V6H4
    Conserved Domains (2) summary
    cd19030
    Location:49 → 239
    LGIC_ECD_nAChR_E; extracellular domain of nicotinic acetylcholine receptor subunit epsilon (CHRNE)
    pfam02932
    Location:247 → 475
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

  4. XM_017597173.3 → XP_017452662.1  acetylcholine receptor subunit epsilon isoform X3

    UniProtKB/TrEMBL
    A6HG68, G3V6H4
    Conserved Domains (2) summary
    cd19030
    Location:49 → 239
    LGIC_ECD_nAChR_E; extracellular domain of nicotinic acetylcholine receptor subunit epsilon (CHRNE)
    pfam02932
    Location:247 → 475
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

  5. XM_017597174.3 → XP_017452663.1  acetylcholine receptor subunit epsilon isoform X4

    Conserved Domains (3) summary
    TIGR00860
    Location:15 → 475
    LIC; Cation transporter family protein
    pfam02931
    Location:24 → 240
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:247 → 474
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

  6. XM_063268811.1 → XP_063124881.1  acetylcholine receptor subunit epsilon isoform X5

  7. XM_063268812.1 → XP_063124882.1  acetylcholine receptor subunit epsilon isoform X6

RNA

  1. XR_010055162.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P09660.2 GenPept UniProtKB/Swiss-Prot:P09660

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