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Dhx16 DEAH-box helicase 16 [ Rattus norvegicus (Norway rat) ]

Gene ID: 294232, updated on 4-Jan-2025

Summary

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Official Symbol
Dhx16provided by RGD
Official Full Name
DEAH-box helicase 16provided by RGD
Primary source
RGD:1302963
See related
EnsemblRapid:ENSRNOG00000030157 AllianceGenome:RGD:1302963
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Dbp2; Ddx16
Summary
Predicted to enable several functions, including helicase activity; pattern recognition receptor activity; and ubiquitin binding activity. Predicted to be involved in antiviral innate immune response and mRNA splicing, via spliceosome. Predicted to be located in nucleoplasm. Predicted to be part of U2-type precatalytic spliceosome. Predicted to be active in cytoplasm. Orthologous to human DHX16 (DEAH-box helicase 16). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Thymus (RPKM 103.3), Kidney (RPKM 93.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Dhx16 in Genome Data Viewer
Location:
20p12
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (2866804..2879790, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (2862000..2874991, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (3368971..3386087, complement)

Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein S18B Neighboring gene alpha tubulin acetyltransferase 1 Neighboring gene similar to human chromosome 6 open reading frame 136 Neighboring gene protein phosphatase 1, regulatory subunit 18 Neighboring gene microRNA 6328 Neighboring gene nurim

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Contribution of DEAH-box protein DHX16 in human pre-mRNA splicing. Gencheva M, et al. Biochem J, 2010 Jul 1. PMID 20423332, Free PMC Article
  2. Cloning and characterization of a human DEAH-box RNA helicase, a functional homolog of fission yeast Cdc28/Prp8. Imamura O, et al. Nucleic Acids Res, 1998 May 1. PMID 9547260, Free PMC Article
  3. GPKOW is essential for pre-mRNA splicing in vitro and suppresses splicing defect caused by dominant-negative DHX16 mutation in vivo. Zang S, et al. Biosci Rep, 2014 Dec 12. PMID 25296192, Free PMC Article
  4. Functions of the DExD/H-box proteins in nuclear pre-mRNA splicing. Chang TH, et al. Biochim Biophys Acta, 2013 Aug. PMID 23454554
  5. Structure of the human activated spliceosome in three conformational states. Zhang X, et al. Cell Res, 2018 Mar. PMID 29360106, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables pattern recognition receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in antiviral innate immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of U2-type precatalytic spliceosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of spliceosomal complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16
Names
DEAH (Asp-Glu-Ala-His) box polypeptide 16
putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16
NP_997661.1
XP_038954408.1
XP_038954409.1
XP_038954410.1
XP_038954411.1
XP_038954412.1
XP_063135067.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_212496.2 → NP_997661.1  pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16

    See identical proteins and their annotated locations for NP_997661.1

    Status: VALIDATED

    Source sequence(s)
    BX883048
    UniProtKB/TrEMBL
    A0A0G2K2E8, A0A9K3Y7B8, D3ZB40, Q6MG13
    Related
    ENSRNOP00000072216.2, ENSRNOT00000089550.3
    Conserved Domains (5) summary
    smart00487
    Location:402 → 584
    DEXDc; DEAD-like helicases superfamily
    smart00847
    Location:801 → 885
    HA2; Helicase associated domain (HA2) Add an annotation
    cd00046
    Location:419 → 558
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd00079
    Location:583 → 740
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    pfam07717
    Location:920 → 1018
    OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086038.1 Reference GRCr8

    Range
    2866804..2879790 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039098484.2 → XP_038954412.1  pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 isoform X5

    Conserved Domains (1) summary
    COG1643
    Location:2 → 583
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]

  2. XM_039098481.2 → XP_038954409.1  pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 isoform X2

    Conserved Domains (2) summary
    PTZ00121
    Location:146 → 410
    PTZ00121; MAEBL; Provisional
    COG1643
    Location:376 → 927
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]

  3. XM_039098480.2 → XP_038954408.1  pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 isoform X1

    Related
    ENSRNOP00000109781.1, ENSRNOT00000157293.1
    Conserved Domains (2) summary
    PTZ00121
    Location:146 → 410
    PTZ00121; MAEBL; Provisional
    COG1643
    Location:376 → 927
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]

  4. XM_039098482.2 → XP_038954410.1  pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 isoform X3

    Conserved Domains (3) summary
    PTZ00121
    Location:146 → 410
    PTZ00121; MAEBL; Provisional
    cl38915
    Location:580 → 621
    DEAD-like_helicase_C; C-terminal helicase domain of the DEAD-like helicases
    cl28899
    Location:402 → 575
    DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

  5. XM_063278997.1 → XP_063135067.1  pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 isoform X4

  6. XM_039098483.2 → XP_038954411.1  pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 isoform X4

    Conserved Domains (2) summary
    PTZ00121
    Location:146 → 410
    PTZ00121; MAEBL; Provisional
    cl28899
    Location:402 → 575
    DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily
Nucleotide Protein Strain
Heading Accession and Version

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