Aif1 allograft inflammatory factor 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Aif1provided by RGD
Official Full Name: allograft inflammatory factor 1provided by RGD
Primary source: RGD:61924
See related: AllianceGenome:RGD:61924
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: iba1; Bart1; mrf-1; BART-1
Summary: Predicted to enable actin filament binding activity and calcium ion binding activity. Involved in several processes, including cellular response to morphine; positive regulation of metabolic process; and positive regulation of muscle hyperplasia. Located in cytoplasm; lamellipodium; and perikaryon. Used to study type 1 diabetes mellitus. Biomarker of brain disease (multiple); glomerulonephritis; interstitial cystitis; meningoencephalitis; and motor neuron disease. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human AIF1 (allograft inflammatory factor 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Spleen (RPKM 801.6), Testes (RPKM 445.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 20p12

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (3651435..3657341)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (3646784..3652670)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (5161350..5167176, complement)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Allograft inflammatory factor-1 enhances inflammation and oxidative stress via the NF-kappaB pathway of bladder urothelium in diabetic rat model.
Title: Allograft inflammatory factor-1 enhances inflammation and oxidative stress via the NF-κB pathway of bladder urothelium in diabetic rat model.
Switching Rat Resident Macrophages from M1 to M2 Phenotype by Iba1 Silencing Has Analgesic Effects in SNL-Induced Neuropathic Pain.
Title: Switching Rat Resident Macrophages from M1 to M2 Phenotype by Iba1 Silencing Has Analgesic Effects in SNL-Induced Neuropathic Pain.
Neurotoxic and cardiotoxic effects of N-methyl-1-(naphthalen-2-yl)propan-2-amine (methamnetamine) and 1-phenyl-2-pyrrolidinylpentane (prolintane).
Title: Neurotoxic and cardiotoxic effects of N-methyl-1-(naphthalen-2-yl)propan-2-amine (methamnetamine) and 1-phenyl-2-pyrrolidinylpentane (prolintane).
Histopathological evaluation of IBA-1, GFAP activity in the brain cortex of rats administered cadmium chloride.
Title: Histopathological evaluation of IBA-1, GFAP activity in the brain cortex of rats administered cadmium chloride.
Human Milk Oligosaccharide 2'-Fucosyllactose Induces Neuroprotection from Intracerebral Hemorrhage Stroke.
Title: Human Milk Oligosaccharide 2'-Fucosyllactose Induces Neuroprotection from Intracerebral Hemorrhage Stroke.
The Crosstalk between Calcium Ions and Aldosterone Contributes to Inflammation, Apoptosis, and Calcification of VSMC via the AIF-1/NF-kappaB Pathway in Uremia.
Title: The Crosstalk between Calcium Ions and Aldosterone Contributes to Inflammation, Apoptosis, and Calcification of VSMC via the AIF-1/NF-κB Pathway in Uremia.
Prenatal exposure to immune activation had a significant main effect on microglial IBA1 immunoreactivity in the corpus callosum.
Title: Late gestation immune activation increases IBA1-positive immunoreactivity levels in the corpus callosum of adult rat offspring.
lumbar disc herniation upregulates microglial Iba1 activity and CGRP expression in many adjacent and ipsilateral lumbar spinal segments
Title: Changes in the Expressions of Iba1 and Calcitonin Gene-Related Peptide in Adjacent Lumbar Spinal Segments after Lumbar Disc Herniation in a Rat Model.
Iba-1-immunoreactive microglia are activated and IFN-gamma and IL-1beta levels are increased in the hippocampal CA1 region and the dentate gyrus of aged, diabetic rats, indicating that chronic diabetes may accelerate aging processes in the hippocampus
Title: Activation of microglia and induction of pro-inflammatory cytokines in the hippocampus of type 2 diabetic rats.
The responses suggest that depending on the type of lesion DRG Iba-1 (+) resident macrophages have different activation mechanisms, which are dissimilar to those in microglia.
Title: Activation profile of dorsal root ganglia Iba-1 (+) macrophages varies with the type of lesion in rats.

Submit: New GeneRIF Correction See all GeneRIFs (18)

General gene information

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Markers

Aif1 (e-PCR), detects polymorphism
- UniSTS:141056

MARC_5857-5858:997299374:1 (e-PCR)
- UniSTS:269591

RH135373 (e-PCR)
- UniSTS:218650

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	ISO Inferred from Sequence Orthology more info
enables actin filament binding	ISS Inferred from Sequence or Structural Similarity more info
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Rac protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in Rac protein signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in actin crosslink formation	ISO Inferred from Sequence Orthology more info
involved_in actin filament bundle assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within actin filament bundle assembly	ISO Inferred from Sequence Orthology more info
involved_in actin filament bundle assembly	ISO Inferred from Sequence Orthology more info
involved_in actin filament bundle assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in actin filament polymerization	ISO Inferred from Sequence Orthology more info
involved_in actin filament polymerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to hormone stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to hydroperoxide	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to morphine	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in cellular response to type II interferon	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to type II interferon	ISO Inferred from Sequence Orthology more info
involved_in cerebellum development	IEP Inferred from Expression Pattern more info	PubMed
involved_in inflammatory response	IEP Inferred from Expression Pattern more info	PubMed
involved_in macrophage activation	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of smooth muscle cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in parallel actin filament bundle assembly	ISO Inferred from Sequence Orthology more info
involved_in phagocytosis, engulfment	ISO Inferred from Sequence Orthology more info
involved_in phagocytosis, engulfment	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of G1/S transition of mitotic cell cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of T cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell migration	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of chemokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fibroblast growth factor production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of monocyte chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of monocyte chemotaxis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of mononuclear cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of muscle hyperplasia	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of nitric oxide biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of nitric oxide biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of smooth muscle cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle cell chemotaxis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of smooth muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to axon injury	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to cytokine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to electrical stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to glucocorticoid	IEP Inferred from Expression Pattern more info	PubMed
involved_in ruffle assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in ruffle assembly	ISO Inferred from Sequence Orthology more info
involved_in ruffle assembly	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
colocalizes_with actin filament	IBA Inferred from Biological aspect of Ancestor more info
located_in actin filament	ISO Inferred from Sequence Orthology more info
located_in actin filament	ISS Inferred from Sequence or Structural Similarity more info
located_in cell projection	IDA Inferred from Direct Assay more info	PubMed
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in glial cell projection	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	IDA Inferred from Direct Assay more info	PubMed
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in perikaryon	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in phagocytic cup	IEA Inferred from Electronic Annotation more info
located_in phagocytic cup	ISO Inferred from Sequence Orthology more info
located_in phagocytic cup	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in ruffle	ISO Inferred from Sequence Orthology more info
colocalizes_with ruffle membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in ruffle membrane	IEA Inferred from Electronic Annotation more info
located_in ruffle membrane	ISO Inferred from Sequence Orthology more info
located_in ruffle membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: allograft inflammatory factor 1

Names: AIF-1; balloon angioplasty responsive transcript; balloon angioplasty-responsive transcript 1; ionized calcium binding adapter molecule 1; microglia response factor; protein BART-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017196.3 → NP_058892.1 allograft inflammatory factor 1

See identical proteins and their annotated locations for NP_058892.1

Status: VALIDATED

Source sequence(s)

BC081822, BX883046, FM053942

UniProtKB/Swiss-Prot

P55007, P55009, P70491

UniProtKB/TrEMBL

A6KTW2

Conserved Domains (1) summary

PTZ00184
Location:38 → 113

PTZ00184; calmodulin; Provisional

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086038.1 Reference GRCr8

Range

3651435..3657341

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063279015.1 → XP_063135085.1 allograft inflammatory factor 1 isoform X1

UniProtKB/TrEMBL

A0A0G2JT08, A6KTW0
XM_006256065.3 → XP_006256127.1 allograft inflammatory factor 1 isoform X1

See identical proteins and their annotated locations for XP_006256127.1

UniProtKB/TrEMBL

A0A0G2JT08, A6KTW0

Conserved Domains (1) summary

PTZ00184
Location:37 → 112

PTZ00184; calmodulin; Provisional
XM_039098495.1 → XP_038954423.1 allograft inflammatory factor 1 isoform X1

UniProtKB/TrEMBL

A0A0G2JT08, A6KTW0

Conserved Domains (1) summary

PTZ00184
Location:37 → 112

PTZ00184; calmodulin; Provisional