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Ube2g2 ubiquitin-conjugating enzyme E2G 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 294331, updated on 27-Nov-2024

Summary

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Official Symbol
Ube2g2provided by RGD
Official Full Name
ubiquitin-conjugating enzyme E2G 2provided by RGD
Primary source
RGD:1304860
See related
EnsemblRapid:ENSRNOG00000001222 AllianceGenome:RGD:1304860
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable identical protein binding activity and ubiquitin conjugating enzyme activity. Predicted to be involved in several processes, including cellular response to interferon-beta; negative regulation of retrograde protein transport, ER to cytosol; and protein K48-linked ubiquitination. Predicted to be located in lipid droplet. Predicted to be active in cytosol and endoplasmic reticulum. Orthologous to human UBE2G2 (ubiquitin conjugating enzyme E2 G2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Muscle (RPKM 196.9), Heart (RPKM 132.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ube2g2 in Genome Data Viewer
Location:
20p12
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (10983322..11005060, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (10983734..11005468, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (11700089..11721823, complement)

Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene thrombospondin-type laminin G domain and EAR repeats Neighboring gene 28S ribosomal protein S36, mitochondrial-like Neighboring gene keratin associated protein 10-9 Neighboring gene small nuclear ribonucleoprotein polypeptide G, pseudogene 3 Neighboring gene small ubiquitin-like modifier 3 Neighboring gene PTTG1 interacting protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Dimeric Ube2g2 simultaneously engages donor and acceptor ubiquitins to form Lys48-linked ubiquitin chains. Liu W, et al. EMBO J, 2014 Jan 7. PMID 24366945, Free PMC Article
  2. Mechanistic insights into active site-associated polyubiquitination by the ubiquitin-conjugating enzyme Ube2g2. Li W, et al. Proc Natl Acad Sci U S A, 2009 Mar 10. PMID 19223579, Free PMC Article
  3. A ubiquitin ligase transfers preformed polyubiquitin chains from a conjugating enzyme to a substrate. Li W, et al. Nature, 2007 Mar 15. PMID 17310145
  4. Endoplasmic reticulum (ER)-associated degradation of T cell receptor subunits. Involvement of ER-associated ubiquitin-conjugating enzymes (E2s). Tiwari S, et al. J Biol Chem, 2001 May 11. PMID 11278356
  5. CYP3A4 ubiquitination by gp78 (the tumor autocrine motility factor receptor, AMFR) and CHIP E3 ligases. Pabarcus MK, et al. Arch Biochem Biophys, 2009 Mar 1. PMID 19103148, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin conjugating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin conjugating enzyme activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within ERAD pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in ERAD pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to interferon-beta ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of retrograde protein transport, ER to cytosol ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K48-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in lipid droplet ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ubiquitin-conjugating enzyme E2 G2
Names
ubiquitin-conjugating enzyme E2G 2 (UBC7 homolog, yeast)
NP_001099850.1
XP_063135125.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106380.2 → NP_001099850.1  ubiquitin-conjugating enzyme E2 G2

    See identical proteins and their annotated locations for NP_001099850.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000020
    UniProtKB/TrEMBL
    A0A8I6GKI1, A0A8J8Y678, B2RYD0, F1MAH9
    Conserved Domains (1) summary
    COG5078
    Location:1 → 163
    COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086038.1 Reference GRCr8

    Range
    10983322..11005060 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063279055.1 → XP_063135125.1  ubiquitin-conjugating enzyme E2 G2 isoform X1

    UniProtKB/TrEMBL
    A6JK78
    Related
    ENSRNOP00000001636.7, ENSRNOT00000001636.9
Nucleotide Protein Strain
Heading Accession and Version

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